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The Critical Importance of Linker Chemistry for Antibody-Drug Conjugates (ADCs)

ADC Chemical Linkers Are Vital The covalent conjugation of monoclonal antibodies (mAbs) and cytotoxic drugs, known as antibody-drug conjugates (ADCs), is rapidly becoming a powerful component of cancer treatment. Hundreds of thousands of research articles and reviews are readily accessible on the World Wide Web, reporting and discussing ADCs in varying levels of detail. However, while much attention has been…

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Schematic drawing of a TOPO coated green quantum dot, approximately 3 nm in diameter.

dPEG® Eliminates Non-Specific Binding on Quantum Dots

What about Quantum Dots? Let's start with a quick refresher. Quantum dots are cool little tiny nano particles, less than 10 nm in diameter, made of a semiconductor alloy core and coated with a shell of a different alloy, which fluoresce at different wavelengths depending on their size and specific composition. The smaller the quantum dot, the more blue-shifted its…

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