Figure4_Maleimide-Reaction-Chemistry - Quanta BioDesign

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Figure 4: The thiol-maleimide reaction. (a) The reaction is chemoselective for thiols from pH 6.5 - 7.5. (b) Above, pH 7.5, thiol chemoselectivity is lost and the maleimide moiety begins reacting with free amines (e.g., lysine).

Detailed view of the thiol-maleimide reaction. (a) The reaction is chemoselective for thiols from pH 6.5 – 7.5. (b) Above, pH 7.5, thiol chemoselectivity is lost and the maleimide moiety begins reacting with free amines (e.g., lysine).