Specs:

 SDS

Molecular Weight: 353.41; single compound

CAS: 905954-28-1

Purity: > 98%

Spacers: dPEG® Spacer is 22 atoms and 25.1 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Synthesis and Preliminary Biological Evaluation of High-Drug-Load Paclitaxel-Antibody Conjugates for Tumor-Targeted Chemotherapy. Sherly Quiles, Kevin P. Raisch, Leisa L. Sanford, James A. Bonner, and Ahmad Safavy, J Med. Chem. 2010, 53 (2), pp 586-594. Dec. 3, 2009. DOI: 10.1021/jm900899g.

TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells. Jaehee Kim, Juhyun Oh, Hannah M Peterson, Jonathan C T Carlson, Mikael J Pittet, Ralph Weissleder. Advanced Biology. 2022. Volume 6, Issue 8. June 8, 2022. https://doi.org/10.1002/adbi.202200030

Additional Search Phrases:

PEG, dPEG, discrete PEG, polyethylene glycol, poly (ethylene glycol), Quanta, Quanta BioDesign, PEGylation reagent, Amino-dPEG6-acid, 905954281, PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, amino acid, carboxyl, active ester, reactive, PEG amino acid, chemical modification, Amino-PEG6-acid, Amino-PEG6-COOH, Carboxy-PEG6-amine, Amino-PEG-acid



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Amino-dPEG®₆-acid

$100.00 – $450.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10067 Categories: , , , , Tags: , , , , , , , , , , , , , , ,

Amino-dPEG®6-acid, product number 10067, is a PEGylated amino acid consisting of a primary amine and a propionic acid on opposite ends of a polyethylene glycol spacer. The PEG spacer is discrete (Ð = 1). Moreover, it is highly hydrophilic. Consequently, it imparts hydrophilicity to conjugates that incorporate it. Furthermore, Amino-dPEG®4-acid is useful in a wide variety of applications. Such applications include peptide synthesis, surface modification, dendrimer construction, and small molecule modification.

Discrete PEG products (sold under the dPEG® trade name) are a particular class of PEG products invented and manufactured by Quanta BioDesign. Because dPEG® products have no dispersity, our customers gain unparalleled control over product development that incorporates PEG linkers and spacers. A complete answer to the question “What is dPEG®?” can be found here. Answers to our most frequently asked questions are on this page.

There are several advantages to using Amino-dPEG®6-acid. The major advantages of using this product include the following:

  • Non-disperse; there is only one length and molecular weight of PEG in the product;
  • A highly pure product that can be characterized easily;
  • Increased water solubility of conjugate molecules;
  • Increased hydrodynamic volume of conjugate molecules;
  • Tremendously improves the flexibility of molecules where it is incorporated into the backbone structure (g., a peptide-PEG construct);
  • Non-antigenic/non-immunogenic;

Both ends of the molecule are available for conjugation. The overall charge of the molecule can be modified by conjugating only one end of the dPEG® spacer. While many different types of coupling reactions effect conjugation, do not use single-step EDC coupling, because this will polymerize the dPEG® product.

In the scientific literature, this product has been used to create a high-drug-load delivery system for Paclitaxel. In applications using other amino-dPEG®-acid products from Quanta BioDesign, our customers have found that these products improve water solubility, eliminate background, or increase the signal-to-noise ratio.

In addition to a dPEG®6 spacer, Quanta BioDesign offers related products containing longer spacers. These products include dPEG®4, dPEG®8, dPEG®12, dPEG®24, and dPEG®36 spacers. Also, we offer an amino-dPEG®24-amido-dPEG®24-acid that consists of two dPEG®24 linkers joined head-to-tail with an amide linkage in the middle.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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