Amino-dPEG®₆-acid

Discrete PEG products (sold under the dPEG^® trade name) are a particular class of PEG products invented and manufactured by Quanta BioDesign. Because dPEG^® products have no dispersity, our customers gain unparalleled control over product development that incorporates PEG linkers and spacers. A complete answer to the question “What is dPEG^®?” can be found here. Answers to our most frequently asked questions are on this page.

There are several advantages to using Amino-dPEG^®₆-acid. The major advantages of using this product include the following:

• Non-disperse; there is only one length and molecular weight of PEG in the product;
• A highly pure product that can be characterized easily;
• Increased water solubility of conjugate molecules;
• Increased hydrodynamic volume of conjugate molecules;
• Tremendously improves the flexibility of molecules where it is incorporated into the backbone structure (g., a peptide-PEG construct);
• Non-antigenic/non-immunogenic;

Both ends of the molecule are available for conjugation. The overall charge of the molecule can be modified by conjugating only one end of the dPEG^® spacer. While many different types of coupling reactions effect conjugation, do not use single-step EDC coupling, because this will polymerize the dPEG^® product.

In the scientific literature, this product has been used to create a high-drug-load delivery system for Paclitaxel. In applications using other amino-dPEG^®-acid products from Quanta BioDesign, our customers have found that these products improve water solubility, eliminate background, or increase the signal-to-noise ratio.

In addition to a dPEG^®₆ spacer, Quanta BioDesign offers related products containing longer spacers. These products include dPEG^®₄, dPEG^®₈, dPEG^®₁₂, dPEG^®₂₄, and dPEG^®₃₆ spacers. Also, we offer an amino-dPEG^®₂₄-amido-dPEG^®₂₄-acid that consists of two dPEG^®₂₄ linkers joined head-to-tail with an amide linkage in the middle.