Specs:

 SDS

Molecular Weight: 545.66; single compound

CAS: 933789-97-0

Spacers: dPEG® Spacer is 38 atoms and 42.7 Å

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Addition of Cleaved Tail Fragments during Lipid Oxidation Stabilizes Membrane Permeability Behavior. Kristina A. Runas, Shiv J. Acharya, Jacob J. Schmidt, and Noah Malmstadt. Langmuir. 2015, December 24, 2015. DOI: 10.1021/acs.langmuir.5b02980.

Real-Time Video Imaging of Protease Expression In Vivo. Lei Zhu, Jin Xie, Magdalena Swierczewska, Fan Zhang, Qimeng Quan, Ying Ma, Xuexun Fang, Kwangmeyung Kim, Seulki Lee, Xiaoyuan Chen. Theranostics. 2011, (1) 2011. 1:18-27 c. http://www.thno.org/v01p0018.htm.

Confocal imaging to quantify passive transport across biomimetic lipid membranes. Su Li, Peichi Hu, and Noah Malmstadt. Analytical Chemistry. 2010, 82 (18) pp 7766-7771. September 15, 2010. DOI: 10.1021/ac1016826

Confocal imaging to quantify passive transport across biomimetic lipid membranes. Su Li, Peichi Hu, and Noah Malmstadt. Analytical Chemistry. 2010, 82 (18) pp 7766-7771. September 15, 2010. DOI: 10.1021/ac1016826.

Label-free electrical detection of pyrophosphate generated from DNA polymerase reactions on field-effect devices. Grace M. Credo, Xing Su, Kai Wu, Oguz H. Elibol, David J. Liua, Bobby Reddy Jr., Ta-Wei Tsai, Brian R. Dorvel, Jonathan S. Daniels, Rashid Bashir, and Madoo Varma. Analyst. 2012 137 (6) p 1351-1362. March 21, 2012. DOI:10.1039/c2an15930a.




Additional Search Phrases: Amino-dPEG12-OH, 933789970, PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, amino alcohol, amine, hydroxyl, alcohol, carboxyl reactive, chemical modification

Amino-dPEG®₁₂-OH

$200.00 – $650.00

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Product#: 10170 Categories: , ,

Amino-dPEG®12-OH, product number 10170, also known as Amino-dPEG®12-alcohol, is a medium-length, monodispersed PEGylation reagent designed for the modification of surfaces and biomolecules. The non-immunogenic, single molecular weight, discrete-length PEG (dPEG®) chain is 38 atoms long (42.7 Å). One end of the molecule terminates with a primary amine, while the other end terminates with a primary alcohol group. This extremely hydrophilic PEGylation reagent modifies biomolecules and surfaces that possess carboxylate groups. If desired, the terminal alcohol moiety can be transformed with appropriate functional groups for further modification of the biomolecule or surface.

How do I use Amino-dPEG®12-OH?

Amino-dPEG®12-OH has many possible uses. The most common uses are modifying biomolecules and passivating surfaces with an extremely hydrophilic coating. The primary amine on one end of the dPEG® linker reacts with carboxylates, aldehydes, and ketones. Conjugations with this molecule most commonly use the amine-carboxylate reaction because it forms stable amide bonds. A carbodiimide such as EDC directly connects the amino group to a carboxylate. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

The amino group also reacts with aldehydes and ketones to form Schiff bases. Schiff bases are reducible to secondary amines for improved stability.

The published uses of Amino-dPEG®12-OH include the following:

  • Stabilization of artificial membranes;
  • Real-time imaging of in vivo protease expression;
  • Development of a confocal imaging system to monitor passive membrane transport; and,
  • Development of a label-free detector of pyrophosphate.

Is Commercial Scale Production of Amino-dPEG®12-OH Available?

Yes, it is. If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Buy It Now!

Amino-dPEG®12-OH is a highly pure monodisperse PEGylation reagent that offers excellent performance in a variety of applications. For over 20 years, we have led the industry in price, quality, performance, and innovation of monodisperse, discrete PEG linkers and spacers. Why look anywhere else?

Click the “Add to Cart” button now to buy this product and discover the dPEG® difference.

Additional information

Weight.5 oz
Dimensions.75 × .75 × 2 in

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