t-boc-N-amido-dPEG®11-amine, product number 10172, is a diamine-functionalized, homobifunctional, monodisperse PEGylation reagent with one of the two primary amine-reactive groups protected as a tert-butyl carbamate. The single molecular weight, discrete-length PEG (dPEG®) chain is 37 atoms (42.8 Å) long. Both ends of the molecule react with carboxylic acids, aldehydes, and ketones. Carboxylic acids react with this product to form amide bonds, while reactions with aldehydes and ketones form Schiff bases that are reducible to secondary amines. The mono-protected end of the molecule gives the user tighter control over crosslinking.
What is dPEG®?
The dPEG® tradename is Quanta BioDesign’s signature branding of single molecular weight, discrete-length PEG products. Unlike traditional polymer PEG products, dPEG® products are exact monodisperse PEG products (Ð = 1). Each dPEG® linker has a single molecular weight with a discrete chain length. Moreover, we synthesize our products carefully from highly pure starting materials rather than purify them from a polymeric mixture. Much more information about our products is available on our “What is dPEG®?” page. Our “Frequently Asked Questions (about dPEG® products)” page answers the questions that our customers ask us most frequently. Please feel free to visit these pages.
How do I use t-boc-N-amido-dPEG®11-amine?
The free amine end of the molecule reacts with carboxylic acids or their active esters. With carboxylic acids, a carbodiimide such as EDC directly couples the amine to the acid, forming the amide. With active esters (for example, NHS or TFP esters) of carboxylic acids, the reaction runs in organic solvents or aqueous buffers using conventional chemistry. After the free amine has reacted, the protected end of the molecule is deprotected with trifluoroacetic acid (TFA) or some other suitable organic acid and then coupled to a carboxylate or active ester as above.
Scientific publications using t-boc-N-amido-dPEG®11-amine describe the following uses for this compound:
Immobilization of enzymes and antibodies;
Construction of supramolecular assemblies;
Engineering of quantum dots; and,
Development of biomolecular sensors.
Is bulk scale production of t-boc-N-amido-dPEG®11-amine available?
If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.
Buy It Now!
t-boc-N-amido-dPEG®11-amine is a unique water-soluble homobifunctional crosslinker from Quanta BioDesign. The discrete PEG crossbridge simplifies the analysis of conjugates made with this product. The monoprotected homobifunctional diamine allows the user tight control over conjugation reactions.
Buy t-boc-N-amido-dPEG®11-amine today and discover the dPEG® difference.
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