Thiol-dPEG®8-acid, product number 10183, is a water-soluble crosslinker containing a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. A sulfhydryl group and a propionic acid group form the linker’s two termini. The sulfhydryl moiety reacts with other sulfhydryls, maleimido groups, the SPDP reactive group, bromoacetamido groups, and gold. Reactions of Thiol-dPEG®8-acid with sulfhydryls or SPDP form disulfide bonds. With maleimido and bromoacetamido compounds, Thiol-dPEG®8-acid reacts to form thioether linkages. Gold forms dative bonds with the sulfhydryl group on Thiol-dPEG®8-acid. The propionic acid moiety couples with free amines to form amide bonds.

PEGylation with dPEG® Products

PEGylation is the process of adding polyethylene glycol (PEG) to molecules or surfaces such as metal, silica, carbon nanoparticles, and glass. Traditional PEG products are disperse polymers. Disperse polymers contain a complex mixture of different polymer chains. Each chain has a different molecular weight. Thus, accurate analysis of such combinations of chain lengths is complicated. Monodisperse PEG products typically are purified from a disperse PEG mixture.

Quanta BioDesign’s dPEG® products are synthesized as small molecules from high purity starting materials. Therefore, our products have no dispersity. In each product, there is but a single, discrete PEG chain with uniform molecular weight. We sell our products under the dPEG® tradename to avoid confusion with the polymeric process implied by the term “monodisperse PEG.” To learn more about Quanta BioDesign’s dPEG® technology, please visit our “What is dPEG®?” page. To find answers to our most frequently asked questions, please click here.

Crosslinking Using Thiol-dPEG®8-acid

In published scientific literature, Thiol-dPEG®8-acid has

  • Labeled polyester nanoparticles with 18F;
  • Functionalized gold nanoparticles with RGD peptides;
  • Demonstrated proof-of-concept detection of pathogenic biomarkers at nM limits; and,
  • Functionalized a localized surface plasmon resonance (LSPR) biosensor integrated with a microfluidic chip.

What can you do with this product?

Commercial Scale Production of Thiol-dPEG®8-acid Is Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Add Thiol-dPEG®8-acid to Your Shopping Cart Today

At Quanta BioDesign, our crosslinkers provide all the benefits of PEG crosslinkers without the severe drawbacks that polymer dispersity brings to product development and analysis. Our high-purity dPEG® products are water-soluble and non-immunogenic. Why use an inferior crosslinker when you can have a superior crosslinker from Quanta BioDesign?

Click the “Add to Cart” button now to start using Thiol-dPEG®8-acid for your next product R&D project.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in