Specs:

 SDS

Molecular Weight: 458.57; single compound

CAS: 866889-02-3

Purity: > 98%

Spacers: dPEG® Spacer is 28 atoms and 32.5 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

CdSe nano-particles coated with thiol-terminated oligo(ethylene oxide) for protein targeting reagent. Yukari Ito and Hiromori Tsutsumi. NSTI-Nanotech. 2009, 2. 2009.

Novel 18F labeling strategy for polyester-based
NPs for in vivo PET-CT imaging. Primiano Pio Di Mauro, Vanessa Gómez-Vallejo, Zurine Baz, Jordi Llop, and Salvador Borros. Bioconjugate Chemistry. 2015. February 24, 2015. DOI: 10.1021/acs.bioconjchem.5b00040.

Cyclic RGD Functionalized Gold Nanoparticles for Tumor Targeting. Daniela Arosio, Leonardo Manzoni, Elena M. V. Araldi, and Carlo Scolastico. Bioconjugate Chem. 2011, 22 (4), pp 664–672. March 24, 2011. DOI: 10.1021/bc100448r.

Biomarker-Mediated Disruption of Coffee-Ring Formation as a Low Resource Diagnostic Indicator. Joshua R. Trantum, David W. Wright, and Frederick R. Haselton. Langmuir, 2012, 28 (4), pp 2187–2193. December 9, 2011. DOI.org/10.1021/la203903a.

Enantioselective analysis of melagatran via a LSPR biosensor integrated with microfluidic chip. Longhua Guo, Yuechun Yin, Rong Huang, Bin Qiu, Zhenyu Lin, HH Yang, Jianrong Li and Guo Nan Chen. Lab on a Chip. 2012, 20 (12), pp 3901-3906. June 15, 2012. DOI: 10.1039/C2LC40388A.

Magnetic Nanoparticle Tracking for One-Step Protein Seperation and Binding Kinetics Analysis. Yunlei Zhao, Guangzhong Ma, Shaopeng Wang. Journal of The Electrochemical Society. 2022. May 11, 2022. dx.doi.org/10.1149/1945-7111/ac6bc5.

Charge-Sensitive Optical Detection of Binding Kinetics between Phage-Displayed Peptide Ligands and Protein Targets. Runli Liang, Yingnan Zhang, Guangzhong Ma, Shaopeng Wang. MDPI. 2022. Biosensors 2022, 12(6), 394. June 8, 2022. https://doi.org/10.3390/bios12060394

Additional Search Phrases:

Thiol-dPEG8-acid, 866889023, PEG, dPEG, discrete PEG, polyethylene glycol, poly (ethylene glycol), Quanta, Quanta BioDesign, PEGylation reagent, thiol acid, thiol PEG acid, thiol-PEG-acid, thiol-PEG acid, chemical modification reagent, metal surface modification, metal surface modification reagent, gold surface, gold nanoparticle, dative bond, dative bonding, PEG8, Thiol-PEG8-acid, Thiol-PEG8-COOH, Carboxy-PEG8-thiol, HS-PEG8-COOH, Thiol-PEG-acid



 SDS    Datasheet

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Thiol-dPEG®₈-acid

$250.00 – $650.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10183 Categories: ,

Thiol-dPEG®8-acid, product number 10183, is a water-soluble crosslinker containing a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. A sulfhydryl group and a propionic acid group form the linker’s two termini. The sulfhydryl moiety reacts with other sulfhydryls, maleimido groups, the SPDP reactive group, bromoacetamido groups, and gold. Reactions of Thiol-dPEG®8-acid with sulfhydryls or SPDP form disulfide bonds. With maleimido and bromoacetamido compounds, Thiol-dPEG®8-acid reacts to form thioether linkages. Gold forms dative bonds with the sulfhydryl group on Thiol-dPEG®8-acid. The propionic acid moiety couples with free amines to form amide bonds.

PEGylation with dPEG® Products

PEGylation is the process of adding polyethylene glycol (PEG) to molecules or surfaces such as metal, silica, carbon nanoparticles, and glass. Traditional PEG products are disperse polymers. Disperse polymers contain a complex mixture of different polymer chains. Each chain has a different molecular weight. Thus, accurate analysis of such combinations of chain lengths is complicated. Monodisperse PEG products typically are purified from a disperse PEG mixture.

Quanta BioDesign’s dPEG® products are synthesized as small molecules from high purity starting materials. Therefore, our products have no dispersity. In each product, there is but a single, discrete PEG chain with uniform molecular weight. We sell our products under the dPEG® tradename to avoid confusion with the polymeric process implied by the term “monodisperse PEG.” To learn more about Quanta BioDesign’s dPEG® technology, please visit our “What is dPEG®?” page. To find answers to our most frequently asked questions, please click here.

Crosslinking Using Thiol-dPEG®8-acid

In published scientific literature, Thiol-dPEG®8-acid has

  • Labeled polyester nanoparticles with 18F;
  • Functionalized gold nanoparticles with RGD peptides;
  • Demonstrated proof-of-concept detection of pathogenic biomarkers at nM limits; and,
  • Functionalized a localized surface plasmon resonance (LSPR) biosensor integrated with a microfluidic chip.

What can you do with this product?

Commercial Scale Production of Thiol-dPEG®8-acid Is Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Add Thiol-dPEG®8-acid to Your Shopping Cart Today

At Quanta BioDesign, our crosslinkers provide all the benefits of PEG crosslinkers without the severe drawbacks that polymer dispersity brings to product development and analysis. Our high-purity dPEG® products are water-soluble and non-immunogenic. Why use an inferior crosslinker when you can have a superior crosslinker from Quanta BioDesign?

Click the “Add to Cart” button now to start using Thiol-dPEG®8-acid for your next product R&D project.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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