Hydroxy-dPEG®₈-t-butyl ester



Hydroxy-dPEG®8-t-butyl ester, product number 10185, is a versatile building block based upon a monodispersed polyethylene glycol (PEG) chain. A primary alcohol group terminates one end of the molecule. The opposite end is a propionic acid group protected as the tert-butyl ester. The terminal hydroxy group can be functionalized with various reactive groups to permit direct modification of surfaces, small molecules, or biomolecules. The tert-butyl ester deprotects with trifluoroacetic acid (TFA), exposing the terminal propionic acid, which can then be activated as the NHS or TFP ester or directly coupled to an amine using a suitable carbodiimide.

What is different about dPEG® products?

Quanta BioDesign’s dPEG® products are uniform (that is, monodispersed) polyethylene glycol (PEG) products. Unlike traditional PEGylation reagents, Quanta BioDesign’s dPEG® products have no dispersity. We synthesize our dPEG® reagents from highly pure building blocks. Our single molecular weight, discrete length PEG (dPEG®) products simplify the analysis of conjugates compared to dispersed PEG products because our dPEG® products contain only one PEG chain. A simplified analysis saves our customers time and money. At Quanta BioDesign, we call the distinction between traditional PEG and dPEG® products, “the dPEG® difference.” To learn more about our dPEG® products, please click on the following links:

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

How do I use Hydroxy-dPEG®8t-butyl ester?

Most of our dPEG® products need no modification before use. However, we cannot anticipate every product type that our customers might need. Therefore, we designed Hydroxy-dPEG®8t-butyl ester for customers who need a dPEG® product that we do not stock. The terminal hydroxy group can be modified, as shown in the application schematic. Upon the completion of modifications to the terminal hydroxy group, the tert-butyl ester can be removed using TFA. Removal of the tert-butyl protecting group exposes the terminal propionic acid. A carbodiimide such as EDC will conjugate amines directly to the propionic acid group to form an amide bond. Alternatively, the propionic acid group can be functionalized as an active ester with N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP).The active ester will then react with amines under slightly basic conditions form an amide bond.

Are bulk quantities of Hydroxy-dPEG®8-t-butyl ester available?

Yes, it is. If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

What are you waiting for?

Our dPEG® products are superior to hydrophobic reagents because they are water-soluble and non-immunogenic. Our products reduce or eliminate non-specific interactions triggered by hydrophobicity. Moreover, our dPEG® products have no dispersity. Our monodispersed dPEG® products simplify the analysis of conjugates, thereby saving our customers time and money.

Discover the dPEG® difference! Click the “Add to Cart” button now to purchase Hydroxy-dPEG®8t-butyl ester.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in