Amino-dPEG®₄-t-butyl ester

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Amino-dPEG®4t-butyl ester, product number 10221, is a crosslinking reagent consisting of a primary amino group and the tert-butyl ester of a propionic acid group built around a core of monodisperse polyethylene glycol (PEG). The terminal amine reacts with carboxylates to form amide bonds and with aldehydes and ketones to form semi-labile, reducible Schiff bases. Trifluoroacetic acid (TFA) effectively removes the tert-butyl ester protecting group, thus freeing the propionic acid for reaction with amines or formation of an active ester with N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP).

Why should I use dPEG® products?

Quanta BioDesign’s dPEG® products provide advantages over both hydrophobic crosslinkers and traditional PEGylation reagents.

PEG-based crosslinkers are superior to hydrophobic crosslinkers because they are amphiphilic, meaning that they dissolve in both water and organic solvents. PEGylation improves water solubility and increases the hydrodynamic volume of conjugates. Conjugates with increased hydrodynamic volumes have longer in vivo circulation times. Also, PEGylated molecules have many fewer or no non-specific interactions due to hydrophobicity.

However, traditional PEGylation reagents are disperse polymers. These products consist of complex mixtures of different PEG chains and molecular weight. This complexity makes conventional PEGylation reagents quite challenging to analyze and characterize.

Contradistinctively, Quanta BioDesign’s dPEG® products are monodisperse, single molecular weight PEGylation reagents synthesized from high-purity starting materials. Each dPEG® product contains a single PEG chain of discrete length and molecular weight. This single-molecule property makes dPEG® products much easier to analyze and characterize.

Learn more about our dPEG® products!

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

How can I use Amino-dPEG®4t-butyl ester?

Amino-dPEG®4-t-butyl ester has various uses. The terminal amino group reacts with the C-termini of peptides or the acid side chains of amino acids forming amide bonds. TFA easily removes the t-butyl ester protecting group, exposing the propionic acid. After deprotection, the propionic acid moiety reacts with amines directly or after the formation of an active ester with, for example, NHS or TFP. The dPEG® chain imparts water solubility, flexibility, and increased hydrodynamic volume to the resulting conjugate. Other potential uses for this product include the following:

  • Construction of unique dPEG®-based reagents;
  • Peptide-Drug Conjugate formation;
  • Supramolecular construction; and,
  • Surface coating of nanoparticles.

Do you sell Amino-dPEG®4-t-butyl ester in bulk?

Yes, we do. We have bulk-scale capabilities with our process-controlled reactors. If you need this product in bulk, please contact us for a quote.

Buy it now!

If you are tired of hydrophobic crosslinkers and the problems they cause, you should try Amino-dPEG®4t-butyl ester. If the thought of analyzing a dispersed PEG polymer product makes you cringe, you should try this product. Stop using inferior crosslinkers! Click the “Add to Cart” button to get started with your order. You, too, will discover the dPEG® difference.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in