Amino-dPEG®8-OH is a monodisperse PEGylation reagent designed for chemical modification of biomolecules and surfaces. The primary amine on one end of the molecule reacts with carboxylates to form amide bonds and with aldehydes and ketones to form labile Schiff bases. The hydrophilic, non-immunogenic dPEG® spacer improves water solubility and increases the hydrodynamic volume of conjugates. The terminal hydroxy can be modified to add different functional groups.

How do I use Amino-dPEG®8-OH?

Amino-dPEG®8-OH has many possible uses. The most common uses are modifying biomolecules and passivating surfaces with an extremely hydrophilic coating. The primary amine on one end of the dPEG® linker reacts with carboxylates, aldehydes, and ketones. Conjugations with this molecule most commonly use the amine-carboxylate reaction because it forms stable amide bonds. A carbodiimide such as EDC directly connects the amino group to a carboxylate. Alternatively, activation of carboxylate as the NHS or TFP ester followed by reaction under slightly basic conditions also permits conjugation of the carboxylate and amino moieties.

The amino group also reacts with aldehydes and ketones to form Schiff bases. Schiff bases are reducible to secondary amines for improved stability.

The published uses of Amino-dPEG®8-OH include the following:

  • Surface coating of iron oxide nanoparticles;
  • Surface coating of quantum dots;
  • Development of a confocal imaging system to measure passive transport across membranes; and,
  • Development of a label-free detector of pyrophosphate.

Is Commercial Scale Production of Amino-dPEG®8-OH Available?

Yes, it is. If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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Amino-dPEG®8-OH is a highly pure monodisperse PEGylation reagent that offers excellent performance in a variety of applications. For over 20 years, we have led the industry in price, quality, performance, and innovation of monodisperse, discrete PEG linkers and spacers. Why look anywhere else?

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in