Fmoc-N-amido-dPEG®2-acid, product number 10243, is one of Quanta BioDesign’s peptide synthesis products. The dPEG®2 spacer allows the introduction of a short, hydrophilic spacer into a peptide chain. The Fmoc protecting group can be removed using standard peptide chemistry.

PEGylation and dPEG® Products

PEGylation refers to the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs. Peptide synthesis frequently employs PEGylation to enhance the solubility of the peptide, because the amphiphilic character of PEG imparts tremendous water solubility to peptides. Moreover, peptide PEGylation prolongs in vivo circulation of peptide conjugates by both increasing the peptide’s hydrodynamic volume and protecting the peptide from proteolysis. Additionally, PEGylation reduces or eliminates the antigenicity of the conjugated peptide.

Traditional PEGs, however, are dispersed polymers (Đ > 1). A traditional PEG consists of multiple different chain lengths with various molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.

Quanta BioDesign’s single molecular weight PEG products (known as “discrete PEG” and sold under the dPEG® trademark) have no dispersity (Ð = 1). Our products provide all of the benefits of traditional, dispersed PEG without the analytical headache that comes from having an intractable mixture of conjugates, each with different PEG chain lengths. For more information on dPEG® products, please visit our “What is dPEG®?” page. For answers to our frequently asked questions, please click here.

Using Fmoc-N-amido-dPEG®2-acid

Fmoc-N-amido-dPEG®2-acid permits our customers to insert a very short dPEG® spacer into a peptide chain using conventional peptide chemistry. The product works equally well in solid-phase and solution-phase synthetic processes. The dPEG® can be joined to the N-terminal end of a peptide chain. After removal of the Fmoc protecting group, further synthesis can be carried out to create a peptide with a flexible hinge. The peptide sequences on either side of the dPEG® spacer can be identical or different.

In addition, the short dPEG® linker can provide spacing between two units in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain water solubility while remaining soluble in an organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Additional Fmoc-dPEG® Products

To help our customers discover the optimum linker length necessary for a particular product or application, Fmoc-N-amido-dPEG®2-acid, product number 10243, is part of a line of Fmoc-protected amino-dPEG® acid products. The list of products in this line are found here. Additionally, we offer a range of Fmoc-protected amino acids activated with either N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP). We invite you to consider all of our Fmoc-protected amino-dPEG®x-acid and active ester products whenever you need a single molecular weight PEG for your application or product development.

Commercial Scale Production

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in