Amino-dPEG®4-acid, product number 10244, is an amino PEG acid. A primary amine and propionic acid terminate the ends of the polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (Ð = 1). Moreover, it is highly hydrophilic. Consequently, it imparts hydrophilicity to conjugates that incorporate it. Furthermore, Amino-dPEG®4-acid is useful in many different applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.

Discrete PEGylation Reagents

Discrete PEG products (sold under the dPEG® trade name) are a unique class of PEG products invented and manufactured by Quanta BioDesign. Our dPEG® products permit unparalleled control over product development that incorporates PEG linkers and spacers because our products have no dispersity. A complete answer to the question “What is dPEG®?” can be found here. Answers to our most frequently asked questions are on this page.

Using Amino-dPEG®4-acid

There are several advantages to using Amino-dPEG®4-acid. The major advantages of using this product include the following:

  • Non-disperse; there is only one length and molecular weight of PEG in the product;
  • Easily characterized, highly pure product;
  • Imparts water solubility to conjugate molecules;
  • Increases the hydrodynamic volume of conjugate molecules;
  • Improves the flexibility of molecules that incorporate Amino-dPEG®4-acid into the backbone structure (g., a peptide-PEG construct);
  • Non-antigenic/non-immunogenic;

Both ends of the molecule are available for conjugation. Conjugation of only one end of the dPEG® spacer may modify the overall charge of the conjugate. Many different types of coupling reactions are effective for this purpose. However, care should be taken not to use single-step EDC coupling, as this will polymerize the dPEG® product.

In the scientific literature, this product has been used to modify diverse compounds including protein microarrays, biological molecules such as antibodies, RGD dimers, and labeled nucleotides. In each case, amino-dPEG®4-acid was shown to improve sensitivity by increasing the signal-to-noise ratio, reducing non-specific binding, or both.

Amino-dPEG®4-acid is part of a large family of amino PEG acid reagents. To see the complete list, please click this link.

Commercial Scale Production of Amino-dPEG®4-acid Is Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Act Now!

Amino-dPEG®4-acid is a highly useful PEGylation reagent for peptide synthesis and small molecule modification. With its single molecular weight and discrete PEG chain length, it is superior to dispersed polymer PEGylation reagents.

Why use inferior reagents when a superior choice is readily available? Click the “Add to Cart” button now to order Amino-dPEG®4-acid.




Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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