Specs:

 SDS

Molecular Weight: 265.30; single compound

CAS: 663921-15-1

Purity: > 98%

Spacers: dPEG® Spacer is 16 atoms and 18.0 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Carboxyl-Terminated Dendrimer-Coated Bioactive Interface for Protein Microarray: High-Sensitivity Detection of Antigen in Complex Biological Samples. Parayil Kumaran Ajikumar, Jin Kiat Ng, Yew Chung Tang, Jim Yang Lee, Gregory Stephanopoulos, and Heng-Phon Too. Langmuir. 2007, 23 (10) pp 5670–5677. March 28, 2007. DOI: 10.1021/la063717u.

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Microwave-Mediated Synthesis of Labeled Nucleotides with Utility in the Synthesis of DNA Probes. Mark Lefever, Jerome W. Kosmeder, II, Michael Farrell, and Christopher Bieniarz. Bioconjugate Chemistry. 2010, 21 (10) pp 1773–1778. September 2, 2010. DOI: 10.1021/bc100013b.

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Influence of Different Spacers on the Biological Profile of a DOTA-Somatostatin Analogue. Patricia Antunes, Mihaela Ginj, Martin A. Walter, Jianhua Chen, Jean-Claude Reubi, and Helmut R. Maecke. Bioconjugate Chemistry. 2007, 18 (1) pp 84–92. December 15, 2006. DOI: 10.1021/bc0601673.

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Short PEG-Linkers Improve the Performance of Targeted, Activatable Monoclonal Antibody-Indocyanine Green Optical Imaging Probes. Kohei Sano, Takahito Nakajima, Kiminori Miyazaki, Yuya Ohuchi, Takashi Ikegami, Peter L. Choyke and Hisataka Kobayashi. Bioconjugate Chemistry. 2013, 24 (5) pp 811–816. April 22, 2013. DOI: 10.1021/bc400050k.

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Improving Tumor-Targeting Capability and Pharmacokinetics of 99mTc-Labeled Cyclic RGD Dimers with PEG4 Linkers. Lijun Wang, Jiyun Shi, Young-Seung Kim, Shizhen Zhai, Bing Jia, Huiyun Zhao, Zhaofei Liu, Fan Wang, Xiaoyuan Chen and Shuang Liu. Molecular Pharmaceutics. 2009, 6 (1) pp 231–245. December 9, 2008. DOI: 10.1021/mp800150r.

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Improving Tumor Uptake and Pharmacokinetics of 64Cu-Labeled Cyclic RGD Peptide Dimers with Gly3 and PEG4 Linkers. Jiyun Shi, Young-Seung Kim, Shizhen Zhai, Zhaofei Liu, Xiaoyuan Chen and Shuang Liu. Bioconjugate Chemistry. 2009, 20 (4) pp 750–759. March 25, 2009. DOI: 10.1021/bc800455p.

HT-SELEX-based identification of binding pre-miRNA hairpin-motif for small molecules. Sanjukta Mukherjee, Asako Murata, Ryoga Ishida, Ayako Sugai, Chikara Dohno, Michiaki Hamada, Sudhir Krishna, Kazuhiko Nakatani. Molecular Therapy Nucleic Acids. 2021. Volume 27, Page 165-174. November 29, 2021. https://doi.org/10.1016/j.omtn.2021.11.021

Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma. Christine Mehner, Alexandra Hockla, Mathew Coban, Benjamin Madden, Rosendo Estrada, Derek C Radisky, Evette S Radisky. Journal Of Biological Chemistry. 2022. Volume 298, Issue 8. June 16, 2022. https://doi.org/10.1016/j.jbc.2022.102146

TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells. Jaehee Kim, Juhyun Oh, Hannah M Peterson, Jonathan C T Carlson, Mikael J Pittet, Ralph Weissleder. Advanced Biology. 2022. Volume 6, Issue 8. June 8, 2022. https://doi.org/10.1002/adbi.202200030

Multiplexed single-cell analysis of FNA allows accurate diagnosis of salivary gland tumors. Juhyun Oh, Tae Yeon Yoo, Talia M Saal, Lisa Tsay , William C Faquin, Jonathan C T Carlson, Daniel G Deschler, Sara I Pai MD PhD, Ralph Weissleder MD PhD. ACS Journals. 2022. Volume 130, Issue 8, p. 581-594. June 6, 2022. https://doi.org/10.1002/cncy.22594.

In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy. Jina Ko, Kilean Lucas, Rainer Kohler, Elias A Halabi, Marin Wikovitsch, Johathan C T Carlson, Ralph Weissleder. Wiley Online Library. 2022. Volume 9, Issue 24. June 24, 2022. https://doi.org/10.1002/advs.202200064

Additional Search Phrases:

Amino-dPEG4-acid, 663921151, PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, amino acid, carboxyl, active ester, reactive, PEG amino acid, chemical modification, Quanta, Quanta BioDesign, Amino-PEG4-acid, Amino-PEG4-COOH, NH2-PEG4-COOH, Carboxy-PEG4-amine, CA(PEG)4, Carboxy-PEG-amine



 SDS    Datasheet

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Amino-dPEG®₄-acid

$100.00 – $350.00

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PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10244 Categories: , , , , Tags: , , , , , , , , , , , , , ,

Amino-dPEG®4-acid, product number 10244, is an amino PEG acid. A primary amine and propionic acid terminate the ends of the polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (Ð = 1). Moreover, it is highly hydrophilic. Consequently, it imparts hydrophilicity to conjugates that incorporate it. Furthermore, Amino-dPEG®4-acid is useful in many different applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.

Discrete PEGylation Reagents

Discrete PEG products (sold under the dPEG® trade name) are a unique class of PEG products invented and manufactured by Quanta BioDesign. Our dPEG® products permit unparalleled control over product development that incorporates PEG linkers and spacers because our products have no dispersity. A complete answer to the question “What is dPEG®?” can be found here. Answers to our most frequently asked questions are on this page.

Using Amino-dPEG®4-acid

There are several advantages to using Amino-dPEG®4-acid. The major advantages of using this product include the following:

  • Non-disperse; there is only one length and molecular weight of PEG in the product;
  • Easily characterized, highly pure product;
  • Imparts water solubility to conjugate molecules;
  • Increases the hydrodynamic volume of conjugate molecules;
  • Improves the flexibility of molecules that incorporate Amino-dPEG®4-acid into the backbone structure (g., a peptide-PEG construct);
  • Non-antigenic/non-immunogenic;

Both ends of the molecule are available for conjugation. Conjugation of only one end of the dPEG® spacer may modify the overall charge of the conjugate. Many different types of coupling reactions are effective for this purpose. However, care should be taken not to use single-step EDC coupling, as this will polymerize the dPEG® product.

In the scientific literature, this product has been used to modify diverse compounds including protein microarrays, biological molecules such as antibodies, RGD dimers, and labeled nucleotides. In each case, amino-dPEG®4-acid was shown to improve sensitivity by increasing the signal-to-noise ratio, reducing non-specific binding, or both.

Amino-dPEG®4-acid is part of a large family of amino PEG acid reagents. To see the complete list, please click this link.

Commercial Scale Production of Amino-dPEG®4-acid Is Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Act Now!

Amino-dPEG®4-acid is a highly useful PEGylation reagent for peptide synthesis and small molecule modification. With its single molecular weight and discrete PEG chain length, it is superior to dispersed polymer PEGylation reagents.

Why use inferior reagents when a superior choice is readily available? Click the “Add to Cart” button now to order Amino-dPEG®4-acid.

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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