Specs:

 SDS

Molecular Weight: 282.35; single compound

CAS: 749247-06-1

Purity: > 98%

Spacers: dPEG® Spacer is 16 atoms and 18.3 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Short-Chain PEG Mixed Monolayer Protected Gold Clusters Increase Clearance and Red Blood Cell Counts. Carrie A. Simpson, Amanda C. Agrawal, Andrzej Balinski, Kellen M. Harkness, and David E. Cliffel. ACS Nano. 2011, 5 (5), pp 3577-3584. April 7, 2011. DOI: 10.1021/nn103148x.

CdSe nano-particles coated with thiol-terminated oligo(ethylene oxide) for protein targeting reagent. Yukari Ito and Hiromori Tsutsumi. NSTI-Nanotech. 2009, 2. 2009.

A Simple Method for Ion Channel Recordings Using Fine Gold Electrode. Daichi Okuno, Minako Hirano, Hiroaki Yokota, Yukiko Onishi, Junya Ichinose, and Toru Ide. Analytical Sciences. 2016, 32 (12) pp 1353-1357. December 10, 2016. http://doi.org.10.2116/analsci.32.1353.

The combination of computational and biosensing technologies for selecting aptamer against prostate specific antigen. Pi-Chou Hsieh, Hui-Ting Lin, Wen-Yih Chen, Jeffrey J.P. Tsai, and Wen-Pin hu. 2017, pp 1-36.

Spatially Resolved Chemical Detection with a Nanoneedle-Probe-Supported Biological Nanopore. Kan Shoji, Ryuji Kawano, and Ryan J. White. ACS Nano, 2019, 13 (2), pp 2606–2614. February 6, 2019. DOI: 10.1021/acsnano.8b09667.

Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor. Hyung Shik Kim, Seung JaeLee, Dong Yun Lee. Bioactive Materials. 2022, Volume 8. 02/2022. DOI: 10.1016/j.bioactmat.2021.06.026

A novel therapeutic strategy of multimodal nanoconjugates for state-of-the-art brain tumor phototherapy. Hyung Shik Kim, Minwook Seo, Tae-Eun Park, and Dong Yun Lee. SpringerLink. 2022. January 4, 2022. https://doi.org/10.1186/s12951-021-01220-9



Additional Search Phrases:

Thiol-dPEG4-acid, 749247061, PEG, dPEG, discrete PEG, polyethylene glycol, poly (ethylene glycol), Quanta, Quanta BioDesign, PEGylation reagent, thiol acid, thiol PEG acid, thiol-PEG-acid, thiol-PEG acid, chemical modification reagent, metal surface modification, metal surface modification reagent, gold surface, gold nanoparticle, dative bond, dative bonding, PEG4, Thiol-PEG4-acid, Thiol-PEG4-COOH, Carboxy-PEG4-thiol, HS-PEG4-COOH, Carboxy-PEG-thiol



 SDS    Datasheet

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Thiol-dPEG®₄-acid

$200.00 – $450.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10247 Categories: ,

Thiol-dPEG®4-acid, product number 10247, is a sulfhydryl-containing, crosslinking PEGylation reagent that has a cross-bridge of monodisperse polyethylene glycol. The sulfhydryl end of the crosslinker reacts with gold (forming dative bonds) and with thiol-reactive functional groups such as maleimide, bromoacetyl, SPDP, and thiol. The carboxylic acid end of the molecule couples to free amines using EDC or any suitable carbodiimide. An acylating agent such as N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) can enhance coupling efficiency. The carboxylate must react after the sulfhydryl conjugation.

PEGylation with dPEG® Reagents

Quanta BioDesign’s dPEG® products differ considerably from conventional PEGylation reagents. Traditional PEGylation reagents are disperse polymers. Even PEG with a dispersity (Ð) as low as 1.05 has a large number of different molecular weights and chain lengths of PEG present in the “pure” product. In contrast, Quanta BioDesign’s products are entirely monodisperse PEG products, which is why we sell them under the dPEG® tradename. For more information about our dPEG® products, please visit our “What is dPEG®?” and “Frequently Asked Questions” pages.

Using Thiol-dPEG®4-acid

Thiol-dPEG®4-acid forms dative bonds with gold surfaces. The short dPEG® product provides a non-immunogenic, hydrophilic spacer between the gold coat and the environment surrounding the gold. The terminal carboxylic acid can be left unmodified, or it can react with amines to crosslink other molecules to the gold.

In published scientific literature, Thiol-dPEG®4-acid in a mixed monolayer has prevented opsonization. Other published uses for this product include coating nanoparticles, coating gold electrodes used in ion channel recording, developing aptamer-based sensors, and developing a chemical detector with nanometer-scale spatial resolution. Many other obvious uses for this product are possible.

Commercial Scale Production of Thiol-dPEG®4-acid Is Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Act Now!

Quanta BioDesign, Ltd., invented discrete PEG technology. Our commitment to high quality, large scale production, and helpful, friendly customer service are unparalleled. Why go anywhere else? Why use a different product?

Click the “Add to Cart” button now and discover the dPEG® difference today.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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