Thiol-dPEG®4-acid, product number 10247, is a sulfhydryl-containing, crosslinking PEGylation reagent that has a cross-bridge of monodisperse polyethylene glycol. The sulfhydryl end of the crosslinker reacts with gold (forming dative bonds) and with thiol-reactive functional groups such as maleimide, bromoacetyl, SPDP, and thiol. The carboxylic acid end of the molecule couples to free amines using EDC or any suitable carbodiimide. An acylating agent such as N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) can enhance coupling efficiency. The carboxylate must react after the sulfhydryl conjugation.

PEGylation with dPEG® Reagents

Quanta BioDesign’s dPEG® products differ considerably from conventional PEGylation reagents. Traditional PEGylation reagents are disperse polymers. Even PEG with a dispersity (Ð) as low as 1.05 has a large number of different molecular weights and chain lengths of PEG present in the “pure” product. In contrast, Quanta BioDesign’s products are entirely monodisperse PEG products, which is why we sell them under the dPEG® tradename. For more information about our dPEG® products, please visit our “What is dPEG®?” and “Frequently Asked Questions” pages.

Using Thiol-dPEG®4-acid

Thiol-dPEG®4-acid forms dative bonds with gold surfaces. The short dPEG® product provides a non-immunogenic, hydrophilic spacer between the gold coat and the environment surrounding the gold. The terminal carboxylic acid can be left unmodified, or it can react with amines to crosslink other molecules to the gold.

In published scientific literature, Thiol-dPEG®4-acid in a mixed monolayer has prevented opsonization. Other published uses for this product include coating nanoparticles, coating gold electrodes used in ion channel recording, developing aptamer-based sensors, and developing a chemical detector with nanometer-scale spatial resolution. Many other obvious uses for this product are possible.

Commercial Scale Production of Thiol-dPEG®4-acid Is Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Act Now!

Quanta BioDesign, Ltd., invented discrete PEG technology. Our commitment to high quality, large scale production, and helpful, friendly customer service are unparalleled. Why go anywhere else? Why use a different product?

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in