Amino-dPEG®₂-t-butyl ester



Amino-dPEG®2t-butyl ester, product number 10264, is a monodispersed polyethylene glycol (PEG) crosslinker. A primary amino group and a tert-butyl ester-protected propionic acid group terminate opposite ends of the crosslinking reagent. The terminal amine reacts with carboxylates to form amide bonds and with aldehydes and ketones to form semi-labile, reducible Schiff bases. The tert-butyl ester protecting group removes easily with trifluoroacetic acid (TFA), leaving the propionic acid free to react with amines or form an active ester with N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP).

Want to learn more about dPEG® products? Click “What is dPEG®?

Do you have questions about which dPEG® products are right for your application? Click “Frequently Asked Questions (about dPEG® products)

How do I use Amino-dPEG®2t-butyl ester?

Amino-dPEG®2-t-butyl ester has various uses.The potential applications for this product include the following:

  • Adding flexibility and improving the water solubility of peptides;
  • Construction of unique dPEG®-based reagents;
  • Creation of Peptide-Drug Conjugates;
  • Supramolecular construction; and,
  • Surface coating of nanoparticles.

Is Amino-dPEG®2-t-butyl ester available in bulk?

Yes, we do. We have bulk-scale capabilities with our process-controlled reactors. For bulk quantities of this product, please contact us for a quote.


Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in