Amino-dPEG®8-acid, product number 10277, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a polyethylene glycol spacer. The highly hydrophilic, discrete PEG spacer (Ð = 1) imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®8-acid is useful in diverse applications. Such applications include peptide synthesis, surface modification, oligonucleotide sequencing, and small molecule modification.

Quanta BioDesign, Ltd., invented, manufactures, and sells discrete PEG products under the dPEG® trade name. Unlike traditional PEG products, our dPEG® products have no dispersity. Thus, dPEG® products permit unparalleled control over product development that includes PEG linkers and spacers. We explain discrete PEG products more fully on our “What is dPEG®?” page. Readers can find answers to our most frequently asked questions by clicking here.

Amino-dPEG®8-acid offers several benefits over comparable amino acids used as spacers. Among the product’s advantages, the following are notable:

  • Only one length and molecular weight of PEG in the product;
  • Easily characterized, highly pure product;
  • Increased water solubility of conjugate molecules compared to the non-PEGylated product;
  • A greater hydrodynamic volume of conjugate molecules compared to the non-PEGylated product;
  • Greatly enhanced flexibility of molecules that incorporate PN10277 into the backbone structure (g., a peptide-PEG construct);
  • Non-antigenic/non-immunogenic;

Both ends of the molecule are available for conjugation. Conjugating only one end of the dPEG® spacer may modify the overall charge of the molecule. Many different types of coupling reactions are useful. However, avoid using a single-step EDC coupling, as this will polymerize the dPEG® product.

Scientific publications report the use of Amino-dPEG®8-acid in modifying diverse compounds including antibodies, enzymes, carbon nanotubes, and SU-8 (an epoxy-based negative photoresist) layered atop a quartz surface. In each case, amino-dPEG®8-acid was shown to improve the performance of the conjugate compared to the unmodified material. The improved conjugate performance occurred through increased signal-to-noise ratio, reduced non-specific binding, or both.

In addition to a dPEG®8 spacer, Quanta BioDesign offers related products containing different lengths in the spacer. These products include dPEG®4, dPEG®6, dPEG®12, dPEG®24, and dPEG®36 spacers. Also, we offer an amino-dPEG®24-amido-dPEG®24-acid that consists of two dPEG®24 linkers joined head-to-tail with an amide linkage in the middle.




Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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