Specs:

 SDS

Molecular Weight: 441.51; single compound

CAS: 756526-04-2

Purity: > 98%

Spacers: dPEG® Spacer is 28 atoms and 32.2 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Spacer length effects on in vitro imaging and surface accessibility of fluorescent inhibitors of prostate specific membrane antigen. Tiancheng Liu, Jessie R. Nedrow-Byers, Mark R. Hopkins, Clifford E. Berkman. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (23), pp 7013–7016 October 4, 2011. DOI:10.1016/j.bmcl.2011.09.115.

Short PEG-Linkers Improve the Performance of Targeted, Activatable Monoclonal Antibody-Indocyanine Green Optical Imaging Probes. Kohei Sano, Takahito Nakajima, Kiminori Miyazaki, Yuya Ohuchi, Takashi Ikegami, Peter L. Choyke and Hisataka Kobayashi. Bioconjugate Chem. 2013, 24 (5) pp 811–816. April 22, 2013. DOI: 10.1021/bc400050k.

Novel 3D LithographicallyPrepared Solid-Phase Surfaces Made from SU-8 for Next Generation Sequencing. Hong Wang, Makgorzata Witek, Daniel Park, Jianmin Huang,Francis Barany, Steven A. Soper. Miniaturized Systems for Chem and Life Sci. 2011, pp.73-75. October 6, 2011. DOI: www.rsc.org/images/LOC/2011/PDFs/Papers/026_0829.pdf

Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes. Elena Heister, Vera Neves, Constanze Lamprecht, S.Ravi P. Silva, Helen M. Coley, Johnjoe McFadden. Carbon. 2011, 50 (2) pp 622-632. August 31, 2011. DOI: 10.1016/j.carbon.2011.08.074.

Enzyme Catalytic Efficiency: A Function of Bio_nano Interface Reactions. Alan S Campbell, Chenbo Dong, Fanke Meng, Jeremy Hardinger, Gabriela C Perhinschi, Nianqiang Wu, and Cerasela Zoica Dinu. ACS Applied Materials and Interfaces. 2014, 6 pp 5393-5403. March 25, 2014. DOI: dx.doi.org/10.1021/am500773g.

Redirecting extracellular proteases to molecularly guide radiosensitizing drugs to tumors. Dina V. Hingorani, Jessica L. Crisp, Matthew K. Doan, Maria F. Camargo, Maryam A. Quraishi, Joseph Aguilera, Mara Gilardi, Larry A.Gross, Tao Jiang, Wei T. Li, Weg M.Ongkeko, Ezra E. W. Cohen, j. Silvio Gutkind, Stephen R. Adams, Sunil J .Advania. Biomaterials. 2020, Volume 248, July 2020, 120032. 04/11/2020. https://doi.org/10.1016/j.biomaterials.2020.120032


Additional Search Phrases:

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 SDS    Datasheet

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Amino-dPEG®₈-acid

$175.00 – $500.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10277 Categories: , , , , Tags: , , , , , , , , , , , ,

Amino-dPEG®8-acid, product number 10277, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a polyethylene glycol spacer. The highly hydrophilic, discrete PEG spacer (Ð = 1) imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®8-acid is useful in diverse applications. Such applications include peptide synthesis, surface modification, oligonucleotide sequencing, and small molecule modification.

Quanta BioDesign, Ltd., invented, manufactures, and sells discrete PEG products under the dPEG® trade name. Unlike traditional PEG products, our dPEG® products have no dispersity. Thus, dPEG® products permit unparalleled control over product development that includes PEG linkers and spacers. We explain discrete PEG products more fully on our “What is dPEG®?” page. Readers can find answers to our most frequently asked questions by clicking here.

Amino-dPEG®8-acid offers several benefits over comparable amino acids used as spacers. Among the product’s advantages, the following are notable:

  • Only one length and molecular weight of PEG in the product;
  • Easily characterized, highly pure product;
  • Increased water solubility of conjugate molecules compared to the non-PEGylated product;
  • A greater hydrodynamic volume of conjugate molecules compared to the non-PEGylated product;
  • Greatly enhanced flexibility of molecules that incorporate PN10277 into the backbone structure (g., a peptide-PEG construct);
  • Non-antigenic/non-immunogenic;

Both ends of the molecule are available for conjugation. Conjugating only one end of the dPEG® spacer may modify the overall charge of the molecule. Many different types of coupling reactions are useful. However, avoid using a single-step EDC coupling, as this will polymerize the dPEG® product.

Scientific publications report the use of Amino-dPEG®8-acid in modifying diverse compounds including antibodies, enzymes, carbon nanotubes, and SU-8 (an epoxy-based negative photoresist) layered atop a quartz surface. In each case, amino-dPEG®8-acid was shown to improve the performance of the conjugate compared to the unmodified material. The improved conjugate performance occurred through increased signal-to-noise ratio, reduced non-specific binding, or both.

In addition to a dPEG®8 spacer, Quanta BioDesign offers related products containing different lengths in the spacer. These products include dPEG®4, dPEG®6, dPEG®12, dPEG®24, and dPEG®36 spacers. Also, we offer an amino-dPEG®24-amido-dPEG®24-acid that consists of two dPEG®24 linkers joined head-to-tail with an amide linkage in the middle.

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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