Fmoc-N-amido-dPEG®₁₂-acid

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Fmoc-N-amido-dPEG®12-acid, product number 10283, is one of Quanta BioDesign’s peptide synthesis products. The dPEG®12 spacer allows the introduction of a long, hydrophilic spacer into a peptide chain.

PEGylation with dPEG® Products

PEGylation refers to the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs. Peptide synthesis frequently employs PEGylation to enhance the solubility of the peptide because the amphiphilic character of PEG imparts tremendous water solubility. Moreover, peptide PEGylation prolongs in vivo circulation of peptide conjugates by both increasing the peptide’s hydrodynamic volume and protecting the peptide from proteolysis. Additionally, PEGylation reduces or eliminates the antigenicity of the conjugated peptide.

Traditional PEGs, however, are dispersed polymers (Đ > 1.00). A traditional PEG consists of multiple chain lengths with various molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.

Quanta BioDesign’s single molecular weight PEG products (known as “discrete PEG” and sold under the dPEG® trademark) provide all of the benefits of traditional, dispersed PEG without the analytical headache that comes from having an intractable mixture of conjugates, each with different PEG chain lengths.

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What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Fmoc-N-amido-dPEG®12-acid permits our customers to insert a medium-length (40 atoms, 46.5 Å) dPEG® into a peptide chain using standard Fmoc chemistry. The product works equally well in solid-phase and solution-phase synthetic processes. The dPEG® can be inserted at either end of the peptide chain or in the middle of two peptides to provide a flexible spacer between distinct peptide chains.

Moreover, the dPEG® spacer can be used to spread out different pieces in a synthetic construct where steric hindrance is a problem. The Fmoc protecting group removes easily with a solution of piperidine in N, N-dimethylformamide (DMF).

Many Applications Use Fmoc-N-amido-dPEG®12-acid

Numerous applications use this product. This page’s reference section contains published scientific papers referencing this product. Applications using Fmoc-N-amido-dPEG®12-acid include the construction of flexible antibodies with non-protein hinges, determination of optimum dPEG® spacer length for maintaining cellular uptake while reducing kidney clearance, and the development of imaging probes.

We Have a Range of Different Products

To help our customers discover the optimum linker length necessary for a particular product or application, Fmoc-N-amido-dPEG®12-acid, product number 10283, is part of a line of Fmoc-protected amino-dPEG® acid products. Also, we offer Fmoc-protected amino acids activated with either N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP). We invite you to consider all of Fmoc-protected amino-dPEG®x-acid and active ester products whenever you need a single molecular weight PEG for your product. These products are available in prepackaged sizes of 100 mg and 1000 mg, but we can produce bulk amounts up to multiple kilogram amounts if you need larger quantities of these products.

Bulk Quantities Are Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in