Description
Specs:
SDS
Molecular Weight: 865.92; single compound
CAS: dPEG®: 2101722-60-3; Polymer: 756525-92-5
Spacers: dPEG® Spacer is 46 atoms and 53.3 Å
References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, as well as his specific discussion with protocols of our MAL-dPEG®x-NHS esters on pp. 718-722.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
Optimal Surface Chemistry for Peptide Immobilization in On-Chip Phosporylation Analysis.Kazuki Inamori, Motoki Kyo, Kazuki Matsukawa, Yusuke Inoue, Tatsuhiko Sonoda, Kenji Tatematsu, Katsuyuki Tanizawa, Takeshi Mori, and Yoshiki Katayama. Analytical Chemistry. 2008, 80 (3), pp 643–650. January 8, 2008. DOI: 10.1021/ac701667g.
Efficient Transfection of Blood-Brain Barrier Endothelial Cells by Lipoplexes and Polyplexes in the Presence of Nuclear Targeting NLS-PEG-Acridine Conjugates. Hongwei Zhang, Anton Mitin, and Serguei V. Vinogradov. Bioconjugate Chemistry. 2009, 20 (1), pp 120–128. December 9, 2008. DOI: 10.1021/bc8003414.
Improved Biodistribution and Radioimmunoimaging with Poly(ethylene glycol)-DOTA-Conjugated Anti-CEA Diabody. Lin li, Paul J. Yazaki, Anne-Line Anderson, Desiree Crow, David Colcher, Anna M. Wu, Lawrence E. Williams, Jeffrey Y.C. Wong, Andrew Raubitschek, and John E. Shively. Bioconjugate Chemistry. 2006, 17 (1), pp 68–76. December 24, 2005. DOI: 10.1021/bc0502614.
A proof of the specificity of kanamycin-ribosomal RNA interaction with designed synthetic analogs and the antibacterial activity. Yoshio Nishimura, Hayamitsu Adachi, Motoki Kyo, Shoichi Murakami, Seiko Hattori, and Keiichi Ajito. Bioorganic & Medicinal Chemistry Letters. 2005, 15 (8), pp 2159-2162. April 15, 2005. DOI: 10.1016/j.bmcl.2005.02.043.
Recognition Imaging with a DNA Aptamer. Liyun Lin, Hongda Wang, Yan Liu, Hao Yan, and Stuart Lindsay. Biophysical Journal. 2006, 90 (11), pp 4236-4238. June 1, 2006. DOI: 10.1529/biophysj.105.079111.
Genotyping by allele-specific L-DNA-tagged PCR. Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani. Journal of Biotechnology. 2008, 135 (2), pp 157-160. June 1, 2008. DOI: 10.1016/j.jbiotec.2008.03.011.
Single-molecule detection of phosphorylation-induced plasticity changes during ezrin activation. Dan Liu, Ling Ge, Fengsong Wang, Hirohide Takahashi, Dongmei Wang, Zhen Guo, Shige H. Yoshimura, Tarsha Ward, Xia Ding, Kunio Takeyasu, Xuebiao Yao. FEBS Letters. 2007, 581 (18), pp 3563-3571. July 24, 2007. DOI: 10.1016/j.febslet.2007.06.071.
Development of glutathione-coupled cantilever for the single-molecule force measurement by scanning force microscopy. Shige H. Yoshimua, Hirohide Takahashi, Shotaro Otsuka, Kunio Takeyasu. FEBS Letters. 2006, 580 (16), pp 3961-3965. July 10, 2006. DOI: 10.1016/j.febslet.2006.06.032.
Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application. Shuji Yamashita, Hiromitsu Fukushima, Yasuyuki Akiyama, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama, Takuro Niidome. Bioorganic & Medicinal Chemistry. 2011, 19 (7), pp 2130-2135. April 1, 2011. DOI: 10.1016/j.bmc.2011.02.042.
Interaction of Synaptotagmin with Lipid Bilayers, Analyzed by Single-Molecule Force Spectroscopy. Hirohide Takahashi, Victor Shahin, Robert M. Henderson, Kunio Takeyasu, and J. Michael Edwardson. Biophysical Journal. 2010, 99 (8), pp 2550–2558, October 20, 2010. DOI: 10.1016/j.bpj.2010.08.047.
Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Jiang Xia, Elin Bergseng, Burkhard Fleckenstein, Matthew Siegel, Chu-Young Kim, Chaitan Khosla and Ludvig M. Sollid. Bioorganic & Medicinal Chemistry. 2007, 15 (20), pp 6565-6573. October 15, 2007. DOI: 10.1016/j.bmc.2007.07.001.
Directed Intermixing in Multicomponent Self-Assembling Biomaterials. Joshua Z. Gasiorowski and Joel H. Collier. Biomacromolecules. 2011, 12 (10), pp 3549–3558. August 25, 2011. DOI: 10.1021/bm200763y.
Design of a Modular Tetrameric Scaffold for the Synthesis of Membrane-Localized D-Peptide Inhibitors of HIV-1 Entry. J. Nicholas Francis, Joseph S. Redman, Debra M. Eckert, and Michael S. Kay. Bioconjugate Chemistry. 2012, 23 (6), pp 1252-1258. May 1, 2012. DOI: 10.1021/bc300076f.
Single-molecule Structural and Functional Analyses of Nuclear Pore Complex. Otsuka, S, Takahashi, H, Yoshimura, Shige H. Micro-NanoMechatronics and Human Science. 2006. November 5, 2006. DOI:10.1109/MHS.2006.320314.
Effect of Compressive Force on Unbinding Specific Protein−Ligand Complexes with Force Spectroscopy. Carleen M. Bowers, David A. Carlson, Monica Rivera, Robert L. Clark, and Eric J. Toone. Journal of Physical Chemistry B. 2013, 117 (17) pp 4755-4762. March 28, 2013. DOI: 10.1021/jp309393s.
Single-molecule anatomy by atomic force microscopy and recognition imaging. Hirohide Takahashi, Kohji Hizume, Masahiro Kumeta, Shige H. Yoshimura and Kunio Takeyasu. Archives of Histology and Cytology. 2009, 72 (4/5) pp 217-225. January 27, 2009. DOI: 10.1679/aohc.72.217.
Attaching Antibodies to AFM Probes with the Sulfhydryl Reactive PEG Tether, NHS-PEG18-PDP. W. Travis Johnson, Ph.D. Agilent Technologies, Inc. 2007, 5989-7702EN. December 18, 2007.
Cell recruitment and transfection in gene activated collagen matrix. Silvia Orsi, Antonia De Capua, Daniela Guarnieri, Daniela Marasco, Paolo A. Netti. Biomaterials. 2010, 31 (3) pp 570–576. January 2010. DOI: 10.1016/j.biomaterials.2009.09.054.
Structural characterization and functionalization of engineered spider silk films. Kristina Spieß, Stefanie Wohlrab and Thomas Scheibel. Soft Matter. 2010, 6 (17) pp 4168-4174. June 16, 2010. DOI: 10.1039/b927267d.
Nanoparticle Self-Assembly Directed by Antagonistic Kinase and Phosphatase Activities. Geoffrey von Maltzahn, Dal-Hee Min, Yingxin Zhang, Ji-Ho Park, Todd J. Harris, Michael Sailor, Sangeeta N. Bhatia. Advance Materials. 2007, 19 (21) pp 3579-3583. October 16, 2007. DOI: 10.1002/adma.200701183.
Cetuximab-conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging. Young-Seok Cho, Tae-Jong Yoon, Eue-Soon Jang, Kwan Soo Hong, Shin Young Lee, Ok Ran Kim, Cheongsoo Park, Yong-Jin Kim, Gyu-Chul Yi, Kiyuk Chang. Cancer Letters. 2010, 299 (1) pp 63-71. December 18, 2010. DOI: 10.1016/j.canlet.2010.08.004.
111In-Labeled Immunoconjugates (Ics) Bispecific for the Epidermal Growth Factor Receptor (EGFR) and Cyclin-Dependent Kinase Inhibitor, p27Kip1. Bart Cornelissen, Veerle Kersemans, Kristin McLarty, Lara Tran, Raymond M. Reilly. Cancer Biotherapy and Radiopharmaceuticals. 2009, 24 (2) pp 163-173. May 1, 2009. DOI: 10.1089/cbr.2008.0553.
U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Rafal Goraczniak, Brian A Wall, Mark A Behlke, Kim A Lennox, Eric S Ho, Nikolas H Zaphiros, Christopher Jakubowski, Neil R Patel, Steven Zhao, Carlo Magaway, Stacey A Subbie, Lumeng Jenny Yu, Stephanie LaCava, Kenneth R Reuhl,Suzie Chen, and Samuel I Gunderson. Molecular Therapy–Nucleic Acids. 2013, 2 (e92). May 14, 2013. DOI: 10.1038/mtna.2013.24.
Small-Animal SPECT/CT of HER2 and HER3 Expression in Tumor Xenografts in Athymic Mice Using Trastuzumab Fab–Heregulin Bispecific Radioimmunoconjugates. Eva J. Razumienko, Deborah A. Scollard, and Raymond M. Reilly. The Journal of Nuclear Medicine. 2012, 53 (12) pp 1943–1950. October 24, 2012. DOI: 10.2967/jnumed.112.106906.
Mass Spectrometry-Guided Optimization and Characterization of a Biologically Active Transferrin−Lysozyme Model Drug Conjugate. Son N. Nguyen, Cedric E. Bobst, and Igor A. Kaltashov. Molecular Pharmaceutics. 2013, 10 (5) pp 1998−2007. March 27, 2013. DOI: org/10.1021/mp400026y.
A sandwich-type DNA array platform for detection of GM targets in multiplex assay. Sena Cansız, Can Ozen, Ceren Bayrac, A. Tahir Bayrac, Fatma Gul, Murat Kavruk, Remziye Yılmaz, Fusun Eyidogan, Huseyin, Avni Oktem. European Food Research and Technology. 2012, 235 (3) pp 429-437. July 6, 2012. DOI: 10.1007/s00217-012-1767-y.
A homogeneous fluorescent sensor for human serum albumin. Rongsheng E. Wang, Ling Tian, Yie-Hwa Chang. Journal of Pharmaceutical and Biomedical Analysis. 2012, 63 pp 165-169. April 7, 2012. DOI :10.1016/j.jpba.2011.12.035.
Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins. David J Marshall, Scott S Harried, John L Murphy, Chad A Hall, Mohammed S Shekhani, Christophe Pain, Conner A Lyons, Antonella Chillemi, Fabio Malavsi, Homer L Pearce, Jon S Thorson, and James R Prudent. MT Open. 2016. July 19, 2016. DOI: 10.1038/mt.2016.119.
Immune Response Modulation of Conjugated Agonists with Changing Linker Length. Keun Ah Ryu, Katarzyna Slowinska, Troy Moore, and Aaron Esser-Kahn. ACS Chemical Biology. 2016, October 17, 2016. DOI: 10.1021/acschembio.6b00895.
Chemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin. Hirobumi Fuchigami, Shino Manabe, Masahiro Yasunaga, and Yasuhiro Matsumura. Scientific Reports. 2018, 8 (14211) pp 1-9. September 21, 2018. DOI: 10.1038/s41598-018-32601-0.
A virus-like particle vaccine platform elicits heightened and hastened local lung mucosal antibody production after a single dose. Laura E. Richert, Amy E. Servid, Ann L. Harmsen, Agnieszka Rynda-Apple, Soo Han, James A. Wiley, Trevor Douglas, Allen G. Harmsen. Vaccine. 2012, 30 (24) pp 3653-3665. May 21, 2012. DOI: 10.1016/j.vaccine.2012.03.035.
Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles. Farnoosh Roohi, Jessica Lohrke, Andreas Ide, Gunnar Schütz, Katrin Dassler. International Journal of Nanomedicine. 2012, 7 pp 4447–4458. August 10, 2012. DOI: 10.2147/IJN.S33120.
Chlorotoxin Labeled Magnetic Nanovectors for Targeted Gene Delivery to Glioma. Forrest M. Kievit, Omid Veiseh, Chen Fang, Narayan Bhattarai, Donghoon Lee, Richard G. Ellenbogen and Miqin Zhang. ACS Nano. 2010, 4 (8) pp 4587–4594. July 20, 2010. DOI: 10.1021/nn1008512.
Creating Antibacterial Surfaces with the Peptide Chrysophsin‑1. Ivan E. Ivanov, Alec E. Morrison, Jesse E. Cobb, Catherine A. Fahey, and Terri A. Camesano. ACS Applied Materials & Interfaces. 2012, 4 (11) pp 5891−5897. October 8, 2012. DOI: 10.1021/am301530a.
Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery. Omid Veiseh, Forrest M. Kievit, Chen Fang, Ni Mu, Soumen Jana, Matthew C. Leung, Hyejung Mok, Richard G. Ellenbogen, James O. Park, Miqin Zhang. Biomaterials. 2010, 31 (31) pp 8032-8042. November 2010. DOI: 10.1016/j.biomaterials.2010.07.016.
Development of a widefield SERS imaging endoscope. Patrick Z .McVeigh, Rupananda J. Mallia, Israel Veilleux, Brian C. Wilson. SPIE Proceedings. 2012, 8217 (1) pp 1-6. February 13, 2012. DOI: 10.1117/12.907304.
Intravital confocal Raman microscopy with multiplexed SERS contrast agents. Patrick Z. McVeigh, Brian C Wilson. Plasmonics in Biology and Medicine IX. 2012, 8234 PP 82340D. February 9, 2012. DOI: 10.1117/12.907048.
Single-molecule imaging, force measurement and fluorescence observation reveal protein and chromosome dynamics around the nuclear envelope. S. Otsuka, Y. Hirano, H. Takahashi, M. Kumeta, K. Takeyasu, and S.H Yoshimura. Micro-NanoMechatronics and Human Science. 2007, pp 310-315. December 1, 2007. DOI: 10.1109/MHS.2007.4420872.
New concept of cytotoxic immunoconjugate therapy targeting cancer-induced fibrin clots. Yasunaga M, Manabe S, Matsumura Y. Cancer Science. 2011, 102 (7) pp 1396-1402. May 9, 2011. DOI: 10.1111/j.1349-7006.2011.01954.x.
New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) II: Albumin Suppresses Angiotensin Converting Enzyme (ACE) Activity in Human. Miklos Fagyas, Katalin Uri, Ivetta M. Siket, Gabor A. Fulop, Viktoria Csato, Andrea Darago, Judit Boczan, Emese Banyai, Istvan Elek Szentkiralyi, Tamas Miklos Maros, Tamas Szerafin, Istvan Edes, Zoltan Papp, Attila Toth. PLoS ONE. 2014, 9 (4) e87844. April, 1 2014. DOI: 10.1371/journal.pone.0087844.
Rapid ratiometric biomarker detection with topically applied SERS nanoparticles. Yu “Winston” Wang, Altaz Khan, Madhura Som, Danni Wang, Ye Chen, Steven Y. Leigh, Daphne Meza, Patrick Z. McVeigh, Brian C. Wilson and Jonathan T.C. Liu. Technology. 2014, 2 (2) pp 1-15. June 2014. DOI: 10.1142/S2339547814500125.
Aptamer-targeted Antigen Delivery. Brian C Wenerter, Joseph A Katakowski, Jacob M Rosenberg, Chae Gyu Park, Steven C Almo, Deborah Palliser and Matthew Levy. Molecular Therapy. 2014, 22 (7) pp 1375-1387. May 6, 2014. DOI: 10.1038/mt.2014.51.
Targeted Intracellular Delivery of Proteins with Spatial and Temporal Control. Demosthenes P. Morales, Gary B. Braun, Alessia Pallaoro, Renwei Chen, Xiao Huang, Joseph A. Zasadzinski and Norbert O. Reich. Molecular Pharmaceutics. 2015, 12 (2) pp 600-609. December 9, 2014. DOI: 10.1021/mp500675p.
Control of Ultrasmall Sub-10 nm Ligand- Functionalized Fluorescent Core-Shell Silica Nanoparticle Growth in Water. Kai Ma, Carlie Mendoza, Margaret Hanson, Ulrike Werner-Zwanziger, Josef Zwanziger and Ulrich Wiesner. Chemistry of Materials. 2015, 27 (11) pp 4119-4133 May 13, 2015. DOI: 10.1021/acs.chemmater.5b01222.
Biocompatible and biodegradable fibrinogen microshperes for tumor-targeted doxorubicin delivery. Jae Yeon Joo, GilYong Park, and Seong Soo A An. International Journal of Nanomedicine. 2015, 10 pp 101-111. September 1, 2015. DOI: 10.2147/IJN.S88381.
3D Porous Chitosan-Alginate Scaffolds as an In Vitro Model for Evaluating Nanoparticle-Mediated Tumor Targeting and Gene Delivery to Prostate Cancer. Kui Wang, Forrest M. Kievit, Stephen J. Florczyk, Zachary R. Stephen, and Miqin Zhang. BioMacromolecules. 2015, September 8, 2015. DOI: 10.1021/acs.biomac.5b01032.
An Approach to Rapid Synthesis and Functionalization of Iron Oxide Nanoparticles for High Gene Transfection. Zachary Stephen, Christopher Dayringer, Josh Lim, Richard Revia, Mackenzie Halbert, Mike Jeon, Arvind Bakthavatsalam, Richard G Ellenbogen, and Miqin Zhang. ACS Applied Materials and Interfaces. 2016, 8(6) pp 3557-4266. February 19, 2016. DOI: 10.1021/acsami.5b10883.
Imaging mass spectrometry for the precise design of antibody-drug conjugates. Yuki Fujiwara, Masaru Furuta, Shino Manabe, Yoshikatsu Koga, Masahiro Yasunaga, and Yasuhiro Matsumura. Scientific Reports. 2016, 6 (24954). April 21, 2016. DOI: 10.1038/srep24954.
Spectroscopy Based Approaches for Detection of Ions, Alpha-L-Fucosidase, and Singlet Oxygen. Eric Waidely. University of Miami Scholarly Repository. 2017, pp 1-113. May 3, 2017. http://scholarlyrepository.miami.edu/oa_dissertations/1842.
Modular and Orthogonal Post-PEGylation Surface Modifications by Insertion Enabling Penta-functional Ultrasmall Organic-Silica Hybrid Nanoparticles. Kai Ma and Ulrich Wiesner. Chemistry of Materials. 2017, pp 1-18. July 23, 2017. DOI: 10.1021/acs.chemmater.7b02009.
Dissecting the cytochrome c2–reaction centre interaction in bacterial photosynthesis using single molecule force spectroscopy. Cvetelin Vasilev, Guy E. Mayneord, Amanda A. Brindley, Matthew P. Johnson, C. Neil Hunter. Biochemical Journal. 2019, 476 (15), pp 2173-2190. July 18, 2019. DOI: 10.1042/BCJ20170519.
Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Dina V. Hingorani, Aaron J. Lemieux, Joseph R. Acevedo, Heather L. Glasgow, Suraj Kedarisetty, Michael A. Whitney, Alfredo A. Molinolo, Roger Y. Tsien, Quyen T. Nguyena Oral Oncol. 2017 Aug;71:156-162. doi: 10.1016/j.oraloncology.2017.06.009. PMID: 28688684
Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers. Timon Hussain, Elamprakash N. Savariar, Julio A. Diaz–Perez, Karen Messer, Minya Pu, Roger Y. Tsien, Quyen T. Nguyen. Head Neck. 2016 May;38(5):715-23. doi: 10.1002/hed.23946. PMID: 25521629
Protein corona formation moderates the release kinetics of ion channel antagonists from transferrin-functionalized polymeric nanoparticles. Priya S. R. Naidu, Eleanor Denhamb, Carole A. Bartlettb, Terry McGonigleb, Nicolas L. Taylor, Marck Norreta, Nicole. M. Smith, Sarah A. Dunlop, K. Swaminathan Iyer and Melinda Fitzgerald. RSC Adv., 2020, 10, 2856-2869. January 15, 2020. DOI: 10.1039/C9RA09523C
A Genomic Profile of Local Immunity in the Melanoma Microenvironment Following Treatment with α Particle-Emitting Ultrasmall Silica Nanoparticles. Aleksandra M. Urbanska, Raya Khanin, Simone Alidori, Sam Wong, Barbara P. Mello, Bryan Aristega Almeida, Feng Chen, Kai Ma, Melik Z. Turker, Tatyana Korontsvit, David A. Scheinberg, Pat B. Zanzonico, Ulrich Wiesner, Michelle S. Bradbury, Thomas P. Quinn, and Michael R. McDevitt. Cancer Biotherapy and Radiopharmaceuticals, 2020. DOI: 10.1089/cbr.2019.3150
Gallium-binding peptides as a tool for the sustainable treatment of industrial waste streams. Nora Schönberger, Corey Taylor, Martin Schrader, Björn Drobot, Sabine Matys, Franziska L. Lederer and Katrin Pollmann. Journal of Hazardous Materials. 2021. Volume 414, 125366. 02/17/2021. DOI: 10.1016/j.jhazmat.2021.125366
Additional Search Phrases: PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, maleimide, maleimido, N-hydroxysuccinimide, NHS, NHS ester, crosslinking, crosslinker, cross linker, heterobifunctional, amine reactive, thiol reactive, PEG12, sulfhydryl reactive, maleimide thiol, PEG thiol, active ester, MAL-PEG12-NHS ester, Maleimide-PEG12-NHS ester, NHS-PEG12-maleimide, SM(PEG)12, NHS-PEG600-maleimide, Maleimide-PEG-NHS ester
Molecular Weight: 865.92; single compound
CAS: dPEG®: 2101722-60-3; Polymer: 756525-92-5
Spacers: dPEG® Spacer is 46 atoms and 53.3 Å
References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, as well as his specific discussion with protocols of our MAL-dPEG®x-NHS esters on pp. 718-722.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
Optimal Surface Chemistry for Peptide Immobilization in On-Chip Phosporylation Analysis.Kazuki Inamori, Motoki Kyo, Kazuki Matsukawa, Yusuke Inoue, Tatsuhiko Sonoda, Kenji Tatematsu, Katsuyuki Tanizawa, Takeshi Mori, and Yoshiki Katayama. Analytical Chemistry. 2008, 80 (3), pp 643–650. January 8, 2008. DOI: 10.1021/ac701667g.
Efficient Transfection of Blood-Brain Barrier Endothelial Cells by Lipoplexes and Polyplexes in the Presence of Nuclear Targeting NLS-PEG-Acridine Conjugates. Hongwei Zhang, Anton Mitin, and Serguei V. Vinogradov. Bioconjugate Chemistry. 2009, 20 (1), pp 120–128. December 9, 2008. DOI: 10.1021/bc8003414.
Improved Biodistribution and Radioimmunoimaging with Poly(ethylene glycol)-DOTA-Conjugated Anti-CEA Diabody. Lin li, Paul J. Yazaki, Anne-Line Anderson, Desiree Crow, David Colcher, Anna M. Wu, Lawrence E. Williams, Jeffrey Y.C. Wong, Andrew Raubitschek, and John E. Shively. Bioconjugate Chemistry. 2006, 17 (1), pp 68–76. December 24, 2005. DOI: 10.1021/bc0502614.
A proof of the specificity of kanamycin-ribosomal RNA interaction with designed synthetic analogs and the antibacterial activity. Yoshio Nishimura, Hayamitsu Adachi, Motoki Kyo, Shoichi Murakami, Seiko Hattori, and Keiichi Ajito. Bioorganic & Medicinal Chemistry Letters. 2005, 15 (8), pp 2159-2162. April 15, 2005. DOI: 10.1016/j.bmcl.2005.02.043.
Recognition Imaging with a DNA Aptamer. Liyun Lin, Hongda Wang, Yan Liu, Hao Yan, and Stuart Lindsay. Biophysical Journal. 2006, 90 (11), pp 4236-4238. June 1, 2006. DOI: 10.1529/biophysj.105.079111.
Genotyping by allele-specific L-DNA-tagged PCR. Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani. Journal of Biotechnology. 2008, 135 (2), pp 157-160. June 1, 2008. DOI: 10.1016/j.jbiotec.2008.03.011.
Single-molecule detection of phosphorylation-induced plasticity changes during ezrin activation. Dan Liu, Ling Ge, Fengsong Wang, Hirohide Takahashi, Dongmei Wang, Zhen Guo, Shige H. Yoshimura, Tarsha Ward, Xia Ding, Kunio Takeyasu, Xuebiao Yao. FEBS Letters. 2007, 581 (18), pp 3563-3571. July 24, 2007. DOI: 10.1016/j.febslet.2007.06.071.
Development of glutathione-coupled cantilever for the single-molecule force measurement by scanning force microscopy. Shige H. Yoshimua, Hirohide Takahashi, Shotaro Otsuka, Kunio Takeyasu. FEBS Letters. 2006, 580 (16), pp 3961-3965. July 10, 2006. DOI: 10.1016/j.febslet.2006.06.032.
Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application. Shuji Yamashita, Hiromitsu Fukushima, Yasuyuki Akiyama, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama, Takuro Niidome. Bioorganic & Medicinal Chemistry. 2011, 19 (7), pp 2130-2135. April 1, 2011. DOI: 10.1016/j.bmc.2011.02.042.
Interaction of Synaptotagmin with Lipid Bilayers, Analyzed by Single-Molecule Force Spectroscopy. Hirohide Takahashi, Victor Shahin, Robert M. Henderson, Kunio Takeyasu, and J. Michael Edwardson. Biophysical Journal. 2010, 99 (8), pp 2550–2558, October 20, 2010. DOI: 10.1016/j.bpj.2010.08.047.
Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Jiang Xia, Elin Bergseng, Burkhard Fleckenstein, Matthew Siegel, Chu-Young Kim, Chaitan Khosla and Ludvig M. Sollid. Bioorganic & Medicinal Chemistry. 2007, 15 (20), pp 6565-6573. October 15, 2007. DOI: 10.1016/j.bmc.2007.07.001.
Directed Intermixing in Multicomponent Self-Assembling Biomaterials. Joshua Z. Gasiorowski and Joel H. Collier. Biomacromolecules. 2011, 12 (10), pp 3549–3558. August 25, 2011. DOI: 10.1021/bm200763y.
Design of a Modular Tetrameric Scaffold for the Synthesis of Membrane-Localized D-Peptide Inhibitors of HIV-1 Entry. J. Nicholas Francis, Joseph S. Redman, Debra M. Eckert, and Michael S. Kay. Bioconjugate Chemistry. 2012, 23 (6), pp 1252-1258. May 1, 2012. DOI: 10.1021/bc300076f.
Single-molecule Structural and Functional Analyses of Nuclear Pore Complex. Otsuka, S, Takahashi, H, Yoshimura, Shige H. Micro-NanoMechatronics and Human Science. 2006. November 5, 2006. DOI:10.1109/MHS.2006.320314.
Effect of Compressive Force on Unbinding Specific Protein−Ligand Complexes with Force Spectroscopy. Carleen M. Bowers, David A. Carlson, Monica Rivera, Robert L. Clark, and Eric J. Toone. Journal of Physical Chemistry B. 2013, 117 (17) pp 4755-4762. March 28, 2013. DOI: 10.1021/jp309393s.
Single-molecule anatomy by atomic force microscopy and recognition imaging. Hirohide Takahashi, Kohji Hizume, Masahiro Kumeta, Shige H. Yoshimura and Kunio Takeyasu. Archives of Histology and Cytology. 2009, 72 (4/5) pp 217-225. January 27, 2009. DOI: 10.1679/aohc.72.217.
Attaching Antibodies to AFM Probes with the Sulfhydryl Reactive PEG Tether, NHS-PEG18-PDP. W. Travis Johnson, Ph.D. Agilent Technologies, Inc. 2007, 5989-7702EN. December 18, 2007.
Cell recruitment and transfection in gene activated collagen matrix. Silvia Orsi, Antonia De Capua, Daniela Guarnieri, Daniela Marasco, Paolo A. Netti. Biomaterials. 2010, 31 (3) pp 570–576. January 2010. DOI: 10.1016/j.biomaterials.2009.09.054.
Structural characterization and functionalization of engineered spider silk films. Kristina Spieß, Stefanie Wohlrab and Thomas Scheibel. Soft Matter. 2010, 6 (17) pp 4168-4174. June 16, 2010. DOI: 10.1039/b927267d.
Nanoparticle Self-Assembly Directed by Antagonistic Kinase and Phosphatase Activities. Geoffrey von Maltzahn, Dal-Hee Min, Yingxin Zhang, Ji-Ho Park, Todd J. Harris, Michael Sailor, Sangeeta N. Bhatia. Advance Materials. 2007, 19 (21) pp 3579-3583. October 16, 2007. DOI: 10.1002/adma.200701183.
Cetuximab-conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging. Young-Seok Cho, Tae-Jong Yoon, Eue-Soon Jang, Kwan Soo Hong, Shin Young Lee, Ok Ran Kim, Cheongsoo Park, Yong-Jin Kim, Gyu-Chul Yi, Kiyuk Chang. Cancer Letters. 2010, 299 (1) pp 63-71. December 18, 2010. DOI: 10.1016/j.canlet.2010.08.004.
111In-Labeled Immunoconjugates (Ics) Bispecific for the Epidermal Growth Factor Receptor (EGFR) and Cyclin-Dependent Kinase Inhibitor, p27Kip1. Bart Cornelissen, Veerle Kersemans, Kristin McLarty, Lara Tran, Raymond M. Reilly. Cancer Biotherapy and Radiopharmaceuticals. 2009, 24 (2) pp 163-173. May 1, 2009. DOI: 10.1089/cbr.2008.0553.
U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Rafal Goraczniak, Brian A Wall, Mark A Behlke, Kim A Lennox, Eric S Ho, Nikolas H Zaphiros, Christopher Jakubowski, Neil R Patel, Steven Zhao, Carlo Magaway, Stacey A Subbie, Lumeng Jenny Yu, Stephanie LaCava, Kenneth R Reuhl,Suzie Chen, and Samuel I Gunderson. Molecular Therapy–Nucleic Acids. 2013, 2 (e92). May 14, 2013. DOI: 10.1038/mtna.2013.24.
Small-Animal SPECT/CT of HER2 and HER3 Expression in Tumor Xenografts in Athymic Mice Using Trastuzumab Fab–Heregulin Bispecific Radioimmunoconjugates. Eva J. Razumienko, Deborah A. Scollard, and Raymond M. Reilly. The Journal of Nuclear Medicine. 2012, 53 (12) pp 1943–1950. October 24, 2012. DOI: 10.2967/jnumed.112.106906.
Mass Spectrometry-Guided Optimization and Characterization of a Biologically Active Transferrin−Lysozyme Model Drug Conjugate. Son N. Nguyen, Cedric E. Bobst, and Igor A. Kaltashov. Molecular Pharmaceutics. 2013, 10 (5) pp 1998−2007. March 27, 2013. DOI: org/10.1021/mp400026y.
A sandwich-type DNA array platform for detection of GM targets in multiplex assay. Sena Cansız, Can Ozen, Ceren Bayrac, A. Tahir Bayrac, Fatma Gul, Murat Kavruk, Remziye Yılmaz, Fusun Eyidogan, Huseyin, Avni Oktem. European Food Research and Technology. 2012, 235 (3) pp 429-437. July 6, 2012. DOI: 10.1007/s00217-012-1767-y.
A homogeneous fluorescent sensor for human serum albumin. Rongsheng E. Wang, Ling Tian, Yie-Hwa Chang. Journal of Pharmaceutical and Biomedical Analysis. 2012, 63 pp 165-169. April 7, 2012. DOI :10.1016/j.jpba.2011.12.035.
Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins. David J Marshall, Scott S Harried, John L Murphy, Chad A Hall, Mohammed S Shekhani, Christophe Pain, Conner A Lyons, Antonella Chillemi, Fabio Malavsi, Homer L Pearce, Jon S Thorson, and James R Prudent. MT Open. 2016. July 19, 2016. DOI: 10.1038/mt.2016.119.
Immune Response Modulation of Conjugated Agonists with Changing Linker Length. Keun Ah Ryu, Katarzyna Slowinska, Troy Moore, and Aaron Esser-Kahn. ACS Chemical Biology. 2016, October 17, 2016. DOI: 10.1021/acschembio.6b00895.
Chemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin. Hirobumi Fuchigami, Shino Manabe, Masahiro Yasunaga, and Yasuhiro Matsumura. Scientific Reports. 2018, 8 (14211) pp 1-9. September 21, 2018. DOI: 10.1038/s41598-018-32601-0.
A virus-like particle vaccine platform elicits heightened and hastened local lung mucosal antibody production after a single dose. Laura E. Richert, Amy E. Servid, Ann L. Harmsen, Agnieszka Rynda-Apple, Soo Han, James A. Wiley, Trevor Douglas, Allen G. Harmsen. Vaccine. 2012, 30 (24) pp 3653-3665. May 21, 2012. DOI: 10.1016/j.vaccine.2012.03.035.
Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles. Farnoosh Roohi, Jessica Lohrke, Andreas Ide, Gunnar Schütz, Katrin Dassler. International Journal of Nanomedicine. 2012, 7 pp 4447–4458. August 10, 2012. DOI: 10.2147/IJN.S33120.
Chlorotoxin Labeled Magnetic Nanovectors for Targeted Gene Delivery to Glioma. Forrest M. Kievit, Omid Veiseh, Chen Fang, Narayan Bhattarai, Donghoon Lee, Richard G. Ellenbogen and Miqin Zhang. ACS Nano. 2010, 4 (8) pp 4587–4594. July 20, 2010. DOI: 10.1021/nn1008512.
Creating Antibacterial Surfaces with the Peptide Chrysophsin‑1. Ivan E. Ivanov, Alec E. Morrison, Jesse E. Cobb, Catherine A. Fahey, and Terri A. Camesano. ACS Applied Materials & Interfaces. 2012, 4 (11) pp 5891−5897. October 8, 2012. DOI: 10.1021/am301530a.
Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery. Omid Veiseh, Forrest M. Kievit, Chen Fang, Ni Mu, Soumen Jana, Matthew C. Leung, Hyejung Mok, Richard G. Ellenbogen, James O. Park, Miqin Zhang. Biomaterials. 2010, 31 (31) pp 8032-8042. November 2010. DOI: 10.1016/j.biomaterials.2010.07.016.
Development of a widefield SERS imaging endoscope. Patrick Z .McVeigh, Rupananda J. Mallia, Israel Veilleux, Brian C. Wilson. SPIE Proceedings. 2012, 8217 (1) pp 1-6. February 13, 2012. DOI: 10.1117/12.907304.
Intravital confocal Raman microscopy with multiplexed SERS contrast agents. Patrick Z. McVeigh, Brian C Wilson. Plasmonics in Biology and Medicine IX. 2012, 8234 PP 82340D. February 9, 2012. DOI: 10.1117/12.907048.
Single-molecule imaging, force measurement and fluorescence observation reveal protein and chromosome dynamics around the nuclear envelope. S. Otsuka, Y. Hirano, H. Takahashi, M. Kumeta, K. Takeyasu, and S.H Yoshimura. Micro-NanoMechatronics and Human Science. 2007, pp 310-315. December 1, 2007. DOI: 10.1109/MHS.2007.4420872.
New concept of cytotoxic immunoconjugate therapy targeting cancer-induced fibrin clots. Yasunaga M, Manabe S, Matsumura Y. Cancer Science. 2011, 102 (7) pp 1396-1402. May 9, 2011. DOI: 10.1111/j.1349-7006.2011.01954.x.
New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) II: Albumin Suppresses Angiotensin Converting Enzyme (ACE) Activity in Human. Miklos Fagyas, Katalin Uri, Ivetta M. Siket, Gabor A. Fulop, Viktoria Csato, Andrea Darago, Judit Boczan, Emese Banyai, Istvan Elek Szentkiralyi, Tamas Miklos Maros, Tamas Szerafin, Istvan Edes, Zoltan Papp, Attila Toth. PLoS ONE. 2014, 9 (4) e87844. April, 1 2014. DOI: 10.1371/journal.pone.0087844.
Rapid ratiometric biomarker detection with topically applied SERS nanoparticles. Yu “Winston” Wang, Altaz Khan, Madhura Som, Danni Wang, Ye Chen, Steven Y. Leigh, Daphne Meza, Patrick Z. McVeigh, Brian C. Wilson and Jonathan T.C. Liu. Technology. 2014, 2 (2) pp 1-15. June 2014. DOI: 10.1142/S2339547814500125.
Aptamer-targeted Antigen Delivery. Brian C Wenerter, Joseph A Katakowski, Jacob M Rosenberg, Chae Gyu Park, Steven C Almo, Deborah Palliser and Matthew Levy. Molecular Therapy. 2014, 22 (7) pp 1375-1387. May 6, 2014. DOI: 10.1038/mt.2014.51.
Targeted Intracellular Delivery of Proteins with Spatial and Temporal Control. Demosthenes P. Morales, Gary B. Braun, Alessia Pallaoro, Renwei Chen, Xiao Huang, Joseph A. Zasadzinski and Norbert O. Reich. Molecular Pharmaceutics. 2015, 12 (2) pp 600-609. December 9, 2014. DOI: 10.1021/mp500675p.
Control of Ultrasmall Sub-10 nm Ligand- Functionalized Fluorescent Core-Shell Silica Nanoparticle Growth in Water. Kai Ma, Carlie Mendoza, Margaret Hanson, Ulrike Werner-Zwanziger, Josef Zwanziger and Ulrich Wiesner. Chemistry of Materials. 2015, 27 (11) pp 4119-4133 May 13, 2015. DOI: 10.1021/acs.chemmater.5b01222.
Biocompatible and biodegradable fibrinogen microshperes for tumor-targeted doxorubicin delivery. Jae Yeon Joo, GilYong Park, and Seong Soo A An. International Journal of Nanomedicine. 2015, 10 pp 101-111. September 1, 2015. DOI: 10.2147/IJN.S88381.
3D Porous Chitosan-Alginate Scaffolds as an In Vitro Model for Evaluating Nanoparticle-Mediated Tumor Targeting and Gene Delivery to Prostate Cancer. Kui Wang, Forrest M. Kievit, Stephen J. Florczyk, Zachary R. Stephen, and Miqin Zhang. BioMacromolecules. 2015, September 8, 2015. DOI: 10.1021/acs.biomac.5b01032.
An Approach to Rapid Synthesis and Functionalization of Iron Oxide Nanoparticles for High Gene Transfection. Zachary Stephen, Christopher Dayringer, Josh Lim, Richard Revia, Mackenzie Halbert, Mike Jeon, Arvind Bakthavatsalam, Richard G Ellenbogen, and Miqin Zhang. ACS Applied Materials and Interfaces. 2016, 8(6) pp 3557-4266. February 19, 2016. DOI: 10.1021/acsami.5b10883.
Imaging mass spectrometry for the precise design of antibody-drug conjugates. Yuki Fujiwara, Masaru Furuta, Shino Manabe, Yoshikatsu Koga, Masahiro Yasunaga, and Yasuhiro Matsumura. Scientific Reports. 2016, 6 (24954). April 21, 2016. DOI: 10.1038/srep24954.
Spectroscopy Based Approaches for Detection of Ions, Alpha-L-Fucosidase, and Singlet Oxygen. Eric Waidely. University of Miami Scholarly Repository. 2017, pp 1-113. May 3, 2017. http://scholarlyrepository.miami.edu/oa_dissertations/1842.
Modular and Orthogonal Post-PEGylation Surface Modifications by Insertion Enabling Penta-functional Ultrasmall Organic-Silica Hybrid Nanoparticles. Kai Ma and Ulrich Wiesner. Chemistry of Materials. 2017, pp 1-18. July 23, 2017. DOI: 10.1021/acs.chemmater.7b02009.
Dissecting the cytochrome c2–reaction centre interaction in bacterial photosynthesis using single molecule force spectroscopy. Cvetelin Vasilev, Guy E. Mayneord, Amanda A. Brindley, Matthew P. Johnson, C. Neil Hunter. Biochemical Journal. 2019, 476 (15), pp 2173-2190. July 18, 2019. DOI: 10.1042/BCJ20170519.
Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Dina V. Hingorani, Aaron J. Lemieux, Joseph R. Acevedo, Heather L. Glasgow, Suraj Kedarisetty, Michael A. Whitney, Alfredo A. Molinolo, Roger Y. Tsien, Quyen T. Nguyena Oral Oncol. 2017 Aug;71:156-162. doi: 10.1016/j.oraloncology.2017.06.009. PMID: 28688684
Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers. Timon Hussain, Elamprakash N. Savariar, Julio A. Diaz–Perez, Karen Messer, Minya Pu, Roger Y. Tsien, Quyen T. Nguyen. Head Neck. 2016 May;38(5):715-23. doi: 10.1002/hed.23946. PMID: 25521629
Protein corona formation moderates the release kinetics of ion channel antagonists from transferrin-functionalized polymeric nanoparticles. Priya S. R. Naidu, Eleanor Denhamb, Carole A. Bartlettb, Terry McGonigleb, Nicolas L. Taylor, Marck Norreta, Nicole. M. Smith, Sarah A. Dunlop, K. Swaminathan Iyer and Melinda Fitzgerald. RSC Adv., 2020, 10, 2856-2869. January 15, 2020. DOI: 10.1039/C9RA09523C
A Genomic Profile of Local Immunity in the Melanoma Microenvironment Following Treatment with α Particle-Emitting Ultrasmall Silica Nanoparticles. Aleksandra M. Urbanska, Raya Khanin, Simone Alidori, Sam Wong, Barbara P. Mello, Bryan Aristega Almeida, Feng Chen, Kai Ma, Melik Z. Turker, Tatyana Korontsvit, David A. Scheinberg, Pat B. Zanzonico, Ulrich Wiesner, Michelle S. Bradbury, Thomas P. Quinn, and Michael R. McDevitt. Cancer Biotherapy and Radiopharmaceuticals, 2020. DOI: 10.1089/cbr.2019.3150
Gallium-binding peptides as a tool for the sustainable treatment of industrial waste streams. Nora Schönberger, Corey Taylor, Martin Schrader, Björn Drobot, Sabine Matys, Franziska L. Lederer and Katrin Pollmann. Journal of Hazardous Materials. 2021. Volume 414, 125366. 02/17/2021. DOI: 10.1016/j.jhazmat.2021.125366
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MAL-dPEG®₁₂-NHS ester
$225.00 – $650.00
MAL-dPEG®12-NHS ester, product number 10284, is one of our top crosslinking reagents. This product joins a sulfhydryl to a free amine through a hydrophilic bridge. The sulfhydryl groups react with a maleimide group via a Michael addition reaction. The amines form amide bonds with the crosslinker by nucleophilic substitution of the N-hydroxysuccinimidyl (NHS) ester of a carboxylic acid group. The maleimide and NHS functional groups on the crosslinking compound sit at either end of a long, discrete-length polyethylene glycol chain (dPEG®).
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MPS-EDA.TFA
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