Specs:

 SDS

Molecular Weight: 751.86; single compound

CAS: 1334177-88-6

Purity: > 98%

Spacers: dPEG® Spacer is 40 atoms and 46.5 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Additional Search Phrases:

CBZ-N-amido-dPEG12-acid, carboxybenzyl, 1334177886, PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, peptide, peptide synthesis, peptide modification, CBZ, carboxybenzyl, amine reactive, acid, monoprotected amino acid, CBZ-protected amino acid, CBZ-N-amido-PEG12-acid, CBZ-NH-PEG12-acid, Z-NH-PEG12-COOH



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CBZ-N-amido-dPEG®₁₂-acid

$150.00 – $650.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10286 Categories: , , ,

CBZ-N-amido-dPEG®12-acid, product number 10286, is a benzyl carbamate (Cbz) N-protected amino-dPEG®-acid that provides a medium-length, single molecular weight discrete PEG (dPEG®) spacer. It can be used in peptide synthesis as well as in many other reactions. In peptide synthesis, removal of the Cbz protecting group is orthogonal to many other protecting groups.

The Cbz protecting group (also called the Z protecting group) is one of the most popular protecting groups for amines. It is stable to base and mildly acidic conditions. Cbz can be cleaved by a variety of methods. The most popular cleavage method is hydrogenolysis, using palladium black or palladium-on-carbon.

PEGylation with dPEG® Products

PEGylation is the covalent attachment of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs. Peptide synthesis frequently employs PEGylation to enhance a peptide’s solubility in water. Moreover, peptide PEGylation prolongs the in vivo circulation of peptide conjugates by both increasing the peptide’s hydrodynamic volume and protecting the peptide from proteolysis. Additionally, PEGylation reduces or eliminates antigenicity of the conjugated peptide.

Quanta BioDesign’s single molecular weight PEG products (known as “discrete PEG” and sold under the dPEG® trademark) provide all of the benefits of traditional, dispersed PEG without the analytical headache that comes from having an intractable mixture of conjugates, each with different PEG chain lengths.

Learn more about Quanta BioDesign’s dPEG® technology!

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Using CBZ-N-amido-dPEG®12-acid

CBZ-N-amido-dPEG®12-acid works well in solution-phase synthesis. Carbodiimide activation, with or without an acylating agent, permits conjugation of the acid terminus of the dPEG® product to free amines. Other synthetic processes (e.g., surface modification, supramolecular construction) requiring the attachment or insertion of a medium-length PEG linker or spacer can employ CBZ-N-amido-dPEG®12-acid profitably also.

The terminal amine of the dPEG® chain is exposed by removal of the Cbz protecting group, making the amine available for additional reactions as needed. As mentioned above, the most popular method of Cbz removal is hydrogenolysis using palladium or palladium-on-carbon.

CBZ-N-amido-dPEG®12-acid is one of many similar products. We invite you to consider our entire family of Cbz-protected amino-dPEG®x-acid products whenever you need a single molecular weight PEG for your product.

Bulk Quantities Are Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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