Specs:

 SDS

Molecular Weight: 617.72; single compound

CAS: 756526-07-4

Purity: > 98%

Spacers: dPEG® Spacer is 40 atoms and 46.5 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Enzyme-Based Nanoscale Composites Composites for Use as Active Decontamination Surfaces. Cerasela Zoica Dinu, Guangyu Zhu, Shyam Sundhar Bale, Gaurav Anand, Philippa J. Reeder, Karl Sanford, Gregg Whited, Ravi S. Kane, and Jonathan S. Dordick. Advance Fuctional Materials. 2010, 20 (3), pp 392-398. February 8, 2010. DOI: 10.1002/adfm.200901388.

Immobilized molecular beacons: A new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events. Catherine Situma, Amanda J. Moehring, Mohamed A.F. Noor, Steven A. Soper. Elsevier, Analytical Biochemistry. 2007, 363 (1), pp 35-45, April 1, 2007. DOI: 10.1016/j.ab.2006.12.029.

Antistaphylococcal Nanocomposite Films Based on Enzyme-Nanotube Conjugates. Ravindra C. Pangule, Sarah J. Brooks, Cerasela Zoica Dinu, Shyam Sundhar Bale, Sharon L. Salmon, Guangyu Zhu, Dennis W. Metzgeter, Ravi S. Kane, and Jonathan S. Dordick. ACS Nano. 2010, 4 (7), pp 3993–4000. July 6, 2010. DOI: 10.1021/nn100932t.

Development of a sensitive surface Plasmon resonance immunosensor for detection of 2, 4-dinitrotoluene with a novel oligo (ethylene glycol)-based sensor surface. Kazutaka Nagatomo, Toshikazu Kawaguchi, Norio Miura, Kiyoshi Toko, Kiyoshi Matsumoto. Elsevier, Talanta. 2009, 79 (4), pp 1142-1148. September 15, 2009. DOI: 10.1016/j.talanta.2009.02.018.

Laccase-and chloroperoxidase-nanotube paint composites with bactericidal and sporicidal activity. Navdeep Grover, Indrakant V. Borkar, Cerasela Zoica Dinu, Ravi S. Kane, Jonathan S. Dordick. Enzyme and Microbial Technology. 2012, 50 (6-7) pp 271-279. May 10, 2012. DOI: 10.1016/j.enzmictec.2012.01.006.

Perhydrolase-nanotube paint composites with sporicidal and antiviral activity. Navdeep Grover, Marc P. Douaisi, Indrakant V. Borkar, Lillian Lee, Cerasela Zoica Dinu, Ravi S. Kane, Jonathan S. Dordick. Applied Microbiology and Biotechnology. 2013, 97 (19), pp 8813-8821. October 1, 2013. DOI: 10.1007/s00253-012-4573-3.

Bionanoconjugate-based composites for decontamination of nerve agents. Indrakant V.Borkar, Cerasela Zoica Dinu, Guangyu Zhu, Ravi S. Kane, and Jonathan S. Dordick. Biotechnology Progress. 2010, 26 (6) pp 1622-1628. September 21, 2010. DOI: 10.1002/btpr.498.

Sequence-Defined Oligoamide Drug Conjugates of Pretubulysin and Methotrexate for Folate Receptor Targeted Cancer Therapy. Ines Truebenbach, Jan Gorges, Jasmin Kuhn, Sarah Kern, Emanuele Baratti, Uli Kazmaier, Ernst Wagner, and Ulrich Lachelt. Macromolecular Bioscience. 2017, pp 1-12. March 30, 2017. DOI: 10.1002/mabi.201600520.




Additional Search Phrases:

Amino-dPEG12-acid, 756526074, PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, amino acid, carboxyl, active ester, reactive, PEG amino acid, chemical modification, Amino-PEG12-acid, Amino-PEG12-COOH, NH2-PEG12-COOH, Carboxy-PEG12-amine, CA(PEG)12, Carboxy-PEG600-amine, Carboxy-PEG-amine



 SDS    Datasheet

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Amino-dPEG®₁₂-acid

$195.00 – $700.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10287 Categories: , , , , Tags: , , , , , , , , , , , ,

Amino-dPEG®12-acid, product number 10287, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a polyethylene glycol spacer. The highly hydrophilic, discrete PEG spacer (Ð = 1) imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®12-acid benefitted numerous applications. These applications include peptide synthesis, surface modification, oligonucleotide sequencing, and small molecule modification.

Quanta BioDesign, Ltd., invented, manufactures, and sells discrete PEG products under the dPEG® trade name. Unlike traditional PEG products, our dPEG® products have no dispersity. Thus, dPEG® products permit unparalleled control over product development that includes PEG linkers and spacers. We explain discrete PEG products more fully on our “What is dPEG®?” page. By clicking here, readers can find answers to our most frequently asked questions.

Amino-dPEG®12-acid offers several benefits over comparable amino acids used as spacers. Among the product’s advantages, the following are notable:

  • Uniform PEG chain length and molecular weight;
  • Easily characterized, highly pure product;
  • Greater water solubility of conjugate molecules than the non-PEGylated product;
  • Increased hydrodynamic volume of conjugate molecules compared to the non-PEGylated product;
  • Greatly enhanced flexibility of molecules where it is incorporated into the backbone structure (g., a peptide-PEG construct);
  • Non-antigenic/non-immunogenic;

Both ends of the molecule are available for conjugation. Conjugation of only one end of the dPEG® spacer may modify the overall charge of the molecule. Many different types of coupling reactions are useful for this purpose. However, avoid using a single-step EDC coupling, as this will polymerize the dPEG® product.

Scientific publications report the use of Amino-dPEG®12-acid in modifying diverse compounds. Among the many applications using this product are peptides, enzymes, molecular beacons, and various types of nanoparticles. Toshikazu Kawaguchi et al., created a surface plasmon resonance (SPR) immunosensor for the detection of 2,4-dinitrotoluene using Amino-dPEG®12-acid. Various groups have created enzyme-based nanoscale products that decontaminate surfaces or that have bactericidal, sporicidal, or viricidal activity.

In addition to a dPEG®12 spacer, Quanta BioDesign offers related products containing different spacer lengths. These products include dPEG®4, dPEG®6, dPEG®8, dPEG®24, and dPEG®36 spacers. Also, we offer an amino-dPEG®24-amido-dPEG®24-acid that consists of two dPEG®24 linkers joined head-to-tail with an amide linkage in the middle.

Description

 

 

 

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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