Amino-dPEG®12-acid, product number 10287, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a polyethylene glycol spacer. The highly hydrophilic, discrete PEG spacer (Ð = 1) imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®12-acid benefitted numerous applications. These applications include peptide synthesis, surface modification, oligonucleotide sequencing, and small molecule modification.

Quanta BioDesign, Ltd., invented, manufactures, and sells discrete PEG products under the dPEG® trade name. Unlike traditional PEG products, our dPEG® products have no dispersity. Thus, dPEG® products permit unparalleled control over product development that includes PEG linkers and spacers. We explain discrete PEG products more fully on our “What is dPEG®?” page. By clicking here, readers can find answers to our most frequently asked questions.

Amino-dPEG®12-acid offers several benefits over comparable amino acids used as spacers. Among the product’s advantages, the following are notable:

  • Uniform PEG chain length and molecular weight;
  • Easily characterized, highly pure product;
  • Greater water solubility of conjugate molecules than the non-PEGylated product;
  • Increased hydrodynamic volume of conjugate molecules compared to the non-PEGylated product;
  • Greatly enhanced flexibility of molecules where it is incorporated into the backbone structure (g., a peptide-PEG construct);
  • Non-antigenic/non-immunogenic;

Both ends of the molecule are available for conjugation. Conjugation of only one end of the dPEG® spacer may modify the overall charge of the molecule. Many different types of coupling reactions are useful for this purpose. However, avoid using a single-step EDC coupling, as this will polymerize the dPEG® product.

Scientific publications report the use of Amino-dPEG®12-acid in modifying diverse compounds. Among the many applications using this product are peptides, enzymes, molecular beacons, and various types of nanoparticles. Toshikazu Kawaguchi et al., created a surface plasmon resonance (SPR) immunosensor for the detection of 2,4-dinitrotoluene using Amino-dPEG®12-acid. Various groups have created enzyme-based nanoscale products that decontaminate surfaces or that have bactericidal, sporicidal, or viricidal activity.

In addition to a dPEG®12 spacer, Quanta BioDesign offers related products containing different spacer lengths. These products include dPEG®4, dPEG®6, dPEG®8, dPEG®24, and dPEG®36 spacers. Also, we offer an amino-dPEG®24-amido-dPEG®24-acid that consists of two dPEG®24 linkers joined head-to-tail with an amide linkage in the middle.





Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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