Specs:

 SDS

Molecular Weight: 559.69; single compound

CAS: 32130-27-1

Purity: > 98%

Spacers: dPEG® Spacer is 38 atoms and 43.9 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Near-Infrared Fluorescent Labeled Peptosome for Application to Cancer Imaging. Hiroki Tanisaka, Shinae Kizaka-Kondoh, Akira Makino, Shotaro Tanaka, masahiro Hiraoka, and Shunsaku Kimura. Bioconjugate Chem. 2008, 19 (1), pp 109–117. December 29, 2007. DOI: 10.1021/bc7001665.

Combined Multimodal Optimal Imaging and Targeted Gene Silencing Using Stimuli-Transforming Nanotheragnostics. Min Suk Shim, Chang Soo Kim, Yeh-Chan Ahn, Zhongping Chen, and Young Jik Kwon. Journal of the American Chemical Society. 2010, 132 (24), pp 8316-8324, June 2, 2010. DOI: 10.1021/ja100580y.

Noncompetitive On-Chip Immunoassays for Detection of Nonlabeled Antibodies Based on the Excluded Volume Effect of the Target Itself. Kin-ya Tomizaki, Masaki Obi, and Hisakazu Mihara. The Chemical Society of Japan Bull Chem. Soc. Jpn, 2011, 1 (85), pp 69-78, December 23, 2011. DOI: 10.1246/bcsj.20110239.

Streptavidin in Antibody Pretargeting. 5. Chemical Modification of Recombinant Streptavidin for Labeling with the α-Particle Emitting Radionuclides 213Bi and 211At. D. Scott Wilbur, Donald K. Hamlin, Ming-Kuan Chyan, and Martin W. Brechbiel. Bioconjugate Chemistry. 2008, 19 (1) pp 158-170. January 19, 2008. DOI:10.1021/bc7002428.

Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand. Wenhao Liu, Andrew B. Greytak, Jungmin Lee, Cliff R. Wong, Jongnam Park, Lisa F. Marshall, Wen Jiang, Peter N. Curtin, Alice Y. Ting, Daniel G. Nocera, Dai Fukumura, Rakesh K. Jain and Moungi G. Bawendi. J. Am. Chem. Soc. 2010, 132 (2) pp 472–483. December 21, 2009. DOI: 10.1021/ja908137d.

Benzene tricarboxamide derivatives with lipid and ethylene glycol chains self-assemble into distinct nanostructures driven by molecular packing, Nada Aljuaid a, Mark Tully b, Jani Seitsonen c, Janne Ruokolainen c and Ian W. Hamley, ChemComm, 2021, 57, 8360, 07/27/2021, DOI: 10.1039/d1cc03437e


Additional Search Phrases:

PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, m-PEG, mPEG, mPEG amine, PEG12, carboxyl reactive, active ester reactive, methoxy, methoxy capped, methoxy terminated, chemical modification reagent, chemical modification reagents, m-PEG12-amine, Methyl-PEG12-amine, mPEG12-NH2 Methyl-PEG12-amine, MA(PEG)12, mPEG600-amine, mPEG-amine



 SDS    Datasheet

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m-dPEG®₁₂-amine

$150.00 – $450.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10288 Categories: , , , , Tags: , , , , , , , , , , , , , , ,

m-dPEG®12-amine, product number 10288, is a non-immunogenic, water-soluble chemical modification reagent. The product contains a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. The dPEG® chain terminates on one end with a methyl group and the other end with an amine. The amino group reacts with carboxylic acids (and their active esters), aldehydes, and ketones. Reacting the amino group with aldehydes or ketones forms a labile imine (Schiff base). Reacting carboxylic acids or their active esters with m-dPEG®12-amine forms stable amide bonds. Uses for this product include passivating surfaces and coating biomolecules.

PEGylation with dPEG® Products

PEGylation is the process of modifying surfaces, small molecules, and biomolecules such as peptides or proteins, with polyethylene glycol (PEG). Conventional PEG reagents are disperse polymers. Polymer dispersity complicates the analysis of conjugates created with them. Quanta BioDesign’s dPEG® products have no dispersity. Instead, each dPEG® product contains a discrete chain length of PEG with a single molecular weight. For a thorough discussion of our dPEG® technology, please visit our “What Is dPEG®?” page. For answers to our most frequently asked questions, please visit this page.

Uses of m-dPEG®12-amine

m-dPEG®12-amine proves useful in surface passivation and coating biomolecules. Biomolecules modified with m-dPEG®12-amine display enhanced water solubility, increased hydrodynamic volume, and reduced immunogenicity. This product reacts quickly with active esters of carboxylic acids (for example, NHS esters and TFP esters) to form amide bonds. Also, it forms amide bonds directly with carboxylic acids using the carbodiimide EDC. Greg Hermanson has published protocols for coupling amines with carboxylic acids, NHS and TFP esters, aldehydes, and ketones in Bioconjugate Techniques, 3rd edition.

Several publications in the scientific literature report the successful use of m-dPEG®12-amine. Published reports using this product include:

  • cancer imaging with a NIR-fluorescent peptosome;
  • multimodal imaging and targeted gene silencing;
  • noncompetitive on-chip immunoassays;
  • antibody pretargeting; and,
  • the development of biocompatible quantum dots.

What will you do with this product?

Commercial Scale Product of m-dPEG®12-amine is Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Buy Now!

Traditional disperse polymer PEG products add unnecessary analytical complexity to conjugates that incorporate them. Quanta BioDesign’s dPEG® products remove that analytical problem because all dPEG® products have a discrete chain length and a single molecular weight. Our products provide all of the benefits of PEG with none of the headaches that polymer PEGs bring.

Stop using inferior products!

Start using single molecular weight dPEG® products and discover the dPEG® difference. To get started, click the “Add to Cart” button now and drop m-dPEG®12-amine in your shopping basket today.

Application Reference:

Greg Hermanson. Bioconjugate Techniques, 3rd Edition. New York: Academic Press, 2013, 1146 pp.

Multiple chapters throughout the book contain reaction protocols. Consult the index for specific page numbers. The most useful procedures are in Chapter 4, “Zero-Length Crosslinkers;” Chapter 5, “Homobifunctional Crosslinkers;” and Chapter 6, “Heterobifunctional Crosslinkers.” Be sure also to check out Chapter 18, “PEGylation and Synthetic Polymer Modification,” where Greg discusses Quanta BioDesign’s dPEG® products in detail.

Many scientists regard Greg’s book as the most authoritative text for bioconjugation work. Quanta BioDesign offers Bioconjugate Techniques, 3rd edition, at a special price. To read a review of the book and to purchase it, please click this link.

Description

 

 

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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