Specs:

 SDS

Molecular Weight: 710.81; single compound

CAS: 88504-24-9

Purity: > 98%

Spacers: dPEG® Spacer is 44 atoms and 50.7 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). See all of the extensive references to the reactions of maleimides with a variety of compounds and applications, Hermanson, p.1174 (index for maleimides) and references therein.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Homodimerisation of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-Labile Disulfide is Critical for Hyaluronan Binding in Lymphatic Endothelium. Suneale Banerji, William Lawrance, Clive Metcalfe, David C. Briggs, Akira Yamauchi, Omer Dushek, P. Anton van der Merwe, Anthony J. Day, and David G. Jackson. The Journal of Biological Chemistry. 2016, October 12, 2016. DOI: 10.1074/jbc.M116.736926.

Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor. Clive Metcalfe, Peter Cresswell and A. Neil Barclay. Open Biology. 2012, 2 (1). January 11, 2012. DOI: 10.1098/rsob.110036.

DksA2, a zinc-independent structural analog of the transcription factor DksA. Ran Furman, Tapan Biswas, Eric M. Danhart, Mark P. Foster, Oleg V. Tsodikov, Irina Artsimovitch. FEBS Letters. 2013, 587 (6) pp 614–619. January 31, 2013. DOI: 10.1016/j.febslet.2013.01.073.

Rapid ratiometric biomarker detection with topically applied SERS nanoparticles. Yu “Winston” Wang, Altaz Khan, Madhura Som, Danni Wang, Ye Chen, Steven Y. Leigh, Daphne Meza, Patrick Z. McVeigh, Brian C. Wilson and Jonathan T.C. Liu. Technology. 2014, 2 (2) pp 1-15. May 19, 2014. DOI: 10.1142/S2339547814500125.

Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase. Manuela Bode, Michael W. Woellhaf, Maria Bohnert, Martin van der Laan, Frederik Sommer, Martin Jung, Richard Zimmermann, Michael Schroda, Johannes M. Herrmann. Molecular Biology of the Cell. April 29, 2015. DOI: 10.1091/mbc.E14-11-1526

A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes. Samantha Ebersoll, Blessing Musunda, Torsten Schmenger, Natalie Dirdjaja, Marian Bonilla, Bruno Manta, Kathrin Ulrich, Marcelo A. Comini, and R. Luise Krauth-Siegel. Redox Biology. 2018, 15, pp 532-547. January 31, 2018. DOI: 10.1016/j.redox.2018.01.011.


Additional Search Phrases:

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 SDS    Datasheet

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m-dPEG®₁₂-MAL

$250.00 – $680.00

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PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10289 Categories: , Tags: , , , , , , , , , , , , ,

m-dPEG®12-MAL, product number 10289, is a sulfhydryl-reactive, single molecular weight, with a discrete chain length PEG (dPEG®). This product modifies surfaces and biomolecules with free thiol groups through the maleimide reactive group. The non-immunogenic, methyl-terminated dPEG® chain has no charge but adds water solubility and hydrodynamic volume to molecules to which it is conjugated.

PEGylation with dPEG® Products

PEGylation is the process of adding polyethylene glycol to a molecule or a surface. PEGylated surfaces include metal, silica, carbon (nanotube, nanosphere, graphene, diamond), liposomes, micelles, and glass. Conventional PEGylation reagents are non-uniform (that is, disperse) polymers. Any given traditional PEG product consists of an intractable mixture of different chain lengths of PEG. Each different PEG chain has a different molecular weight. The analytical challenges that arise from using dispersed polymers are complex and possibly impenetrable.

Quanta BioDesign’s single molecular weight dPEG® products are different from traditional PEG products. Because they are synthesized from high-purity starting materials, our dPEG® products have no dispersity and are like small molecules. With each dPEG® products, there is only one molecular weight and one chain length of PEG. Hence, the PEG products are discrete, which is why we sell them under the dPEG® tradename. To learn more about our dPEG® products, please visit our “What is dPEG®?” page. For answers to our most frequently asked questions, please click here.

Uses for m-dPEG®12-MAL

The reaction of the maleimide end of m-dPEG®12-MAL, product number 10289, with a sulfhydryl proceeds best at pH 6.5 – 7.5. Conduct the conjugation at the lowest reasonable pH within this range. Above pH 7.5, free amines compete with free thiols at the maleimide reaction site, which creates confusing results. Moreover, at higher pH values, the maleimide ring may open to form unreactive maleamic acid. For details about maleimide-thiol reaction chemistry, please click here.

Published uses for m-dPEG®12-MAL include probing the molecular structure and function of proteins and coating nanoparticle surfaces. In particular, studies of molecular structure and function of proteins would not be possible with traditional, dispersed PEG products because the dispersed PEGs would have created an indecipherable mixture of conjugation products. Only a dPEG® product could work in this application.

Commercial Scale Production Is Available for m-dPEG®12-MAL

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Act Now

Why use inferior, dispersed PEG products when you can use a single molecular weight dPEG® product? Quanta BioDesign offers dPEG®-based crosslinkers that provide water solubility, improved hydrodynamic volume, no background noise (which means better signal), and no protein precipitation caused by aggregation. Why use anything else?

For better bioconjugation reactions than you have ever had before, click the “Add to Cart” button now. You will not regret it.

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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