m-dPEG®₁₅-amine

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m-dPEG®15-amine, product number 10298, is a non-immunogenic, water-soluble chemical modification reagent. The product contains a monodisperse, single molecular weight, discrete-length polyethylene glycol (dPEG®) chain that is 47 atoms (53.4 Å) long. One end of the dPEG® chain terminates with a methyl group and the other end with an amine. The amino group reacts with carboxylic acids (and their active esters) to form amide bonds. Reactions with aldehydes or ketones form a labile imine known as a Schiff base. Uses for this product include passivating surfaces, coating biomolecules, and building dendrimers and other supramolecular constructs.

dPEG® Products as PEGylation Reagents

PEGylation is the process of modifying surfaces, small molecules, and biomolecules (e.g., peptides, proteins, and lipids) with polyethylene glycol (PEG). Conventional PEGylation reagents are disperse polymers. Polymer dispersity complicates the analysis of conjugates created with them.

Quanta BioDesign’s dPEG® products have no dispersity. Instead, each dPEG® product contains a discrete chain length of PEG with a single molecular weight. Our monodisperse dPEG® PEGylation reagents simplify the analysis and characterization of conjugates made with them. All the benefits of PEG remain, but the complications that come from using disperse polymer products vanish. At Quanta BioDesign, we call this “the dPEG® difference.”

Learn more about our dPEG® technology and products!

What Is dPEG®?

Frequently Asked Questions (about dPEG® products)

Using m-dPEG®15-amine

m-dPEG®15-amine proves useful in building dendrimers, coating biomolecules, and passivating surfaces. Constructs that incorporate m-dPEG®15-amine display enhanced water solubility, increased hydrodynamic volume, and reduced immunogenicity. Carboxylic acids and their active esters (for example, NHS esters and TFP esters) readily form amide bonds with this product. Direct conjugation of carboxylic acids and m-dPEG®15-amine require a carbodiimide such as EDC. Greg Hermanson has published protocols for coupling amines with carboxylic acids, NHS and TFP esters, aldehydes, and ketones in Bioconjugate Techniques, 3rd edition.

Possible applications of m-dPEG®15-amine include:

  • Imaging applications (enhanced water solubility, increased hydrodynamic volume, reduced immunogenicity, surface passivation);
  • Antibody modification (reduced immunogenicity); and,
  • Nanoparticle and quantum dot surface passivation.

What will you do with this product?

Commercial Scale Product of m-dPEG®15-amine is Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Buy Now!

Our products provide all the benefits of traditional PEG products without the analytical complexity caused by dispersed PEG polymers. We call this the dPEG® difference. If you want to experience the dPEG® difference in your product development, click the “Add to Cart” button now.

Application Reference:

Greg Hermanson. Bioconjugate Techniques, 3rd Edition. New York: Academic Press, 2013, 1146 pp.

Multiple chapters throughout the book contain reaction protocols. Consult the index for specific page numbers. The most useful procedures are in Chapter 4, “Zero-Length Crosslinkers;” Chapter 5, “Homobifunctional Crosslinkers;” and Chapter 6, “Heterobifunctional Crosslinkers.” Be sure also to check out Chapter 18, “PEGylation and Synthetic Polymer Modification,” where Greg discusses Quanta BioDesign’s dPEG® products in detail.

Many scientists regard Greg’s book as the most authoritative text for bioconjugation work. Quanta BioDesign offers Bioconjugate Techniques, 3rd edition, at a special price. To read a review of the book and to purchase it, please click this link.

 

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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