m-dPEG®₂₄-NHS ester

$225.00$850.00

Clear

TFP_Esters_Art2

m-dPEG®24-NHS ester, product number 10304, is a long (74 atoms, 86.2 Å), methyl-terminated, discrete length polyethylene glycol (dPEG®) spacer. With a reactive end as the N-hydroxysuccinimidyl (NHS) ester, m-dPEG®24-NHS ester is designed to modify surfaces containing accessible free amines. Except for the reactive end group, this product is identical to m-dPEG®24-TFP ester, product number 10303.

Free amines react optimally at pH 7.2 – 7.5 in aqueous media with NHS esters. Furthermore, in aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases as the pH increases. Also, it should be noted that reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Many applications employ m-dPEG®24-NHS ester. Published papers using this product include uses in:

  • cell surface engineering;
  • PK and immunogenicity improvements for poly-L-lysine dendrimers used as drug delivery vehicles to tumors;
  • multimodal imaging;
  • stable antimicrobial, cytotoxic dendrimers;
  • quantum dot micelles for imaging applications;
  • coating of nanoparticles, quantum dots, and carbon nanotubes; and,
  • preventing enzyme aggregation.

m-dPEG®24-NHS ester, product number 10304, is just one member of an comprehensive line of methyl-terminated dPEG® products. This line includes dPEG® spacers containing 2 to 49 ethylene glycol units. These products are functionalized with NHS or with 2,3,5,6-tetrafluorophenol (TFP). TFP has proven to be superior to NHS for amine-reactive products. For more information on the superior performance of TFP esters, please see our page TFP Esters Have More Hydrolytic Stability and Greater Reactivity than NHS Esters.

Quanta BioDesign, Ltd., makes and sells single molecular weight PEG linkers and spacers with discrete chain lengths under the trade name dPEG®. Our products are distinctly different from traditional PEG products in that they are not disperse polymers. However, they confer all of the benefits of traditional PEG products. To learn more about dPEG® products, please read our page What is dPEG®? Please also visit our Frequently Asked Questions page to get answers to the questions we answer most often.

Description

 

 

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

You may also like…