Fmoc-N-amido-dPEG®₂₄-acid

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Fmoc-N-amido-dPEG®24-acid, product number 10313, is one of Quanta BioDesign’s peptide synthesis products. The dPEG®24 spacer allows the introduction of a long, hydrophilic spacer into a peptide chain.

PEGylation with dPEG® Products

PEGylation refers to the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs. Peptide synthesis often uses PEGylation to enhance the peptide’s water solubility. Moreover, peptide PEGylation prolongs the in vivo circulation of peptide conjugates by both increasing the peptide’s hydrodynamic volume and protecting the peptide from proteolysis. Additionally, PEGylation reduces or eliminates the conjugated peptide’s antigenicity.

Traditional PEGs, however, are dispersed polymers (Đ > 1.00). A traditional PEG consists of multiple chain lengths with different molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.

Quanta BioDesign’s single molecular weight PEG products (known as “discrete PEG” and sold under the dPEG® trademark) provide all of the benefits of traditional, dispersed PEG without the analytical headache that comes from having an intractable mixture of conjugates, each with different PEG chain lengths.

Learn more!

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Using Fmoc-N-amido-dPEG®24-acid

Fmoc-N-amido-dPEG®24-acid permits our customers to insert a long (76 atoms, 100.9 – 101.9 Å) dPEG® into a peptide chain using well-known chemistry. The product works equally well in solid phase and solution phase synthetic processes. The dPEG® can be inserted at either end of the peptide chain or in the middle of two peptides to provide a flexible spacer between distinct peptide chains.

Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The Fmoc protecting group removes easily with a solution of piperidine in N, N-dimethylformamide (DMF).

Fmoc-N-amido-dPEG®24-acid Used in Published Scientific Papers

Numerous applications use Fmoc-N-amido-dPEG®24-acid. The references section of this page lists published scientific papers referencing this product. Applications using Fmoc-N-amido-dPEG®24-acid include developing flexible antibodies with non-protein hinges, creating high DAR antibody-drug conjugates, optimizing the compaction and shielding on pDNA constructs, and maintaining cellular uptake while minimizing kidney clearance.

We Offer Many Different Fmoc-protected Amino-dPEG® Acids

To help our customers discover the optimum linker length necessary for a particular product or application, Fmoc-N-amido-dPEG®24-acid, product number 10313, is part of a line of Fmoc-protected amino-dPEG® acid products. Also, we offer Fmoc-protected amino acids activated with either N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP). We invite you to consider our entire line of Fmoc-protected amino-dPEG®x-acid and active ester products whenever you need a single molecular weight PEG for your product.

Bulk Quantities Area Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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Description

 

 

 

 

 

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in