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Molecular Weight: 1146.35; single compound

CAS: 756526-07-5

Spacers: dPEG® Spacer is 76 atoms and 89.0 Å

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

PEG-Labeled Nucleotides and Nanopore Detection for Single Molecule DNA Sequencing by Synthesis. Shiv Kumar, Chuanjuan Tao, Minchen Chien, Brittney Hellner, Arvind Balijepalli, Joseph W. F. Robertson, Zengmin Li, James J. Russo, Joseph E. Reiner3, John J. Kasianowicz & Jingyue Ju. Scientific Reports. 2012, 2 (684), September 21, 2012. DOI: 10.1038/srep00684.

Proton-sponge activity and receptor-targeting of sequence-defined nucleic acid carriers. Ulrich Benjamin Lachelt. October 21, 2014.

ICAM-1 Targeted Catalase Encapsulated PLGA-b-PEG Nanoparticles against Vascular Oxidative Stress. Sari, E.; Tunc-Sarisozen, Y.; Mutlu, H.; Shahbazi, R.; Ucar, G.; Ulubayram, K. Journal of Microencapsulation 2015, 32 (7), 687–698. https://doi.org/10.3109/02652048.2015.1073384.

Additional Search Phrases: Amino-dPEG24-acid, 756526074, PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, amino acid, carboxyl, active ester, reactive, PEG amino acid, chemical modification, Amino-PEG24-acid, NH2-PEG24-COOH, Carboxy-PEG24-amine, CA(PEG)24, Amino-PEG1000-acid, Carboxy-PEG-amine

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 Datasheet

Amino-dPEG®₂₄-acid

$225.00 – $850.00

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Product#: 10317 Categories: , , Tags: , , , , , , , , , , , ,

Amino-dPEG®24-acid, product number 10317, is a PEGylated amino acid. A primary amine group and a propionic acid group sit on opposite ends of a polyethylene glycol spacer. The highly hydrophilic, discrete PEG spacer (Ð = 1) imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®24-acid benefitted a variety of applications. These applications include peptide synthesis, surface modification, oligonucleotide sequencing, and small molecule modification.

Quanta BioDesign, Ltd., invented, manufactures, and sells discrete PEG products under the dPEG® trade name. Unlike traditional PEG products, our dPEG® products have no dispersity. Thus, dPEG® products permit unparalleled control over product development that includes PEG linkers and spacers. We explain discrete PEG products more fully on our “What is dPEG®?” page. Readers can find answers to our most frequently asked questions by clicking here.

Amino-dPEG®24-acid offers several benefits over comparable amino acids used as spacers. Among the product’s advantages, the following are notable:

  • Uniform PEG chain length and molecular weight;
  • Easily characterized, highly pure product;
  • Improved water solubility of conjugate molecules compared to the non-PEGylated product;
  • Increased hydrodynamic volume of conjugate molecules compared to the non-PEGylated product;
  • Enhanced flexibility of molecules that incorporate PN10317 into the backbone structure (g., a peptide-PEG construct);
  • Non-antigenic/non-immunogenic;

Both ends of the molecule are available for conjugation. Conjugating only one end of PN10317 to a target molecule may modify the overall charge of the conjugate. Many different types of coupling reactions can be used. However, avoid using a single-step EDC coupling, as this will polymerize the dPEG® product.

Several scientific publications and patents report the use of Amino-dPEG®24-acid in modifying diverse compounds. Among the various applications using this product are aptamers, quantum dots, therapeutic peptides, and DNA polymerase for nucleotide sequencing.

In addition to a dPEG®24 spacer, Quanta BioDesign offers related products containing longer or shorter spacers. These products include dPEG®4, dPEG®6, dPEG®8, dPEG®12, and dPEG®36 spacers. Also, we offer an amino-dPEG®24-amido-dPEG®24-acid that consists of two dPEG®24 linkers joined head-to-tail with an amide linkage in the middle.

Description

 

 

 

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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