Specs:

 SDS

Molecular Weight: 1239.44; single compound

CAS: 88504-24-9

Purity: > 98%

Spacers: dPEG® Spacer is 80 atoms and 50.7 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Modulation of Cell Surface Protein Free Thiols: A Potential Novel Mechanism of Action of the Sesquiterpene Lactone Parthenolide. Jolanta Skalska, Paul S. Brookes, Sergiy M. Nadtochiy, Shannon P. Hilchey, Craig T. Jordan, Monica L. Guzman, Sanjay B. Maggirwar, Margaret M. Briehl, Steven H. Bernstein. PLoS ONE. 4 (12), e8115. December 2, 2009. DOI: 10.1371 /journal.pone.0008115.

Cell-Specific Delivery of Diverse Cargos by BacteriophageMS2 Virus-like Particles. Carlee E. Ashley Eric C. Carnes, Genevieve K. Phillips, Paul N. Durfee, Mekensey D. Buley, Christopher A. Lino, David P. Padilla, Brandy Phillips, Mark B. Carter, Cheryl L. Willman, C. Jeffrey Brinker, Jerri do Carmo Caldeira, Bryce Chackerian, Walker Wharton, and David S. Peabody.ACS Nano, 2011, 5 (7), pp 5729–5745, May 26, 2011. DOI: 10.1021/nn201397z.

Going through the barrier: coupled disulfide exchange reactions promote efficient catalysis in Quiescin sulfhydryl oxidase. Benjamin A. Israel, Vamsi K. Kodali, and Colin Thorpe. The Journal of Biological Chemistry. 2013, December 30, 2013. DOI: 10.1074/jbc.M113.536219.

2-Cys peroxiredoxins participate in the oxidation of chloroplast enzymes in the dark. Valle Ojeda, Juan Manuel, Pérez-Ruiz, and Francisco Javier Cejudo. Molecular Plant. 2018, pp 1-32. October 4, 2018. DOI: 10.1016/j.molp.2018.09.005.

Complement Activation and Cell Uptake Responses Toward Polymer-Functionalized Protein Nanocapsules. Nicholas M. Molino, Kateryna Bilotkach, Deborah A. Fraser, Dongmei Ren, and Szu-Wen Wang. Biomacromolecules, 2012, 13 (4), pp 974–981. March 14, 2012. DOI: 10.1021/bm300083e.

Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase. Manuela Bode, Michael W. Woellhaf, Maria Bohnert, Martin van der Laan, Frederik Sommer, Martin Jung, Richard Zimmermann, Michael Schroda, Johannes M. Herrmann. Molecular Biology of the Cell. April 29, 2015. DOI: 10.1091/mbc.E14-11-1526

NTRC-dependent redox balance of 2-Cys peroxiredoxins is needed for optimal function of the photosynthetic apparatus. Juan Manuel Pérez-Ruiz, Belén Naranjo, Valle Ojeda, Manuel Guinea, and Francisco Javier Cejudo. Proceedings of the National Academy of Sciences of the United States of America. 2017, 114 (45) pp 12069-12074. 9/26/2017. DOI: 10.1073/pnas.1706003114.

A chloroplast redox relay adapts plastid metabolism to light and affects cytosolic protein quality control. Valle Ojeda, Julia Jiménez-López, Francisco José Romero-Campero, Francisco Javier Cejudo, Juan Manuel Pérez-Ruiz. Plant Physiology. 2021, kiab246. 05/26/2021. DOI: 10.1093/plphys/kiab246

Protocol for determining protein cysteine thiol redox status using western blot analysis, Bikram Datt Pant, Sunhee Oh, Hee-Kyung Lee, Raja Sekhar Nandety, Kirankumar S. Mysore, Volume 33, Issue 11, 15 December 2020, https://doi.org/10.1016/j.xpro.2021.100566

Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control, Danyun Zhang, Owen R. Dailey, Daniel J. Simon, James A. Wohlschlegel, Carla M. Koehler, Deepa V. Dabir, Journal of Biological Chemistry, 2021, Volume 297, Issue 4, 10/2021, DOI: 10.1016/j.jbc.2021.101135

Depletion of m-type thioredoxin impairs photosynthesis, carbon fixation, and oxidative stress in cyanobacteria. Manuel J Mallén-Ponce, María José Huertas, Ana María Sánchez-Riego, Francisco J Florencio. Plant Physiology. 2021. Volume 187, Issue 3. July 15, 2021. DOI: 10.1093/plphys/kiab321

Characterization of the Gluathione-dependent reduction of the perixiredoxin 5 homolog PfAOP from Plasmodium Falciparum. Robin Chumann, Lukas Lang, Marcel Deponte. Wiley Online Library. 2022. Volume 31, Issue 5. April 9, 2022. https://doi.org/10.1002/pro.4290

Regulation of Derlin-1-mediated degradation of NADPH oxidase partner p22phox by thiol modification. Kei Miyano, Shuichiro Okamoto, Mizuho Kajikawa, Takuya Kiyohara, Chikage Kawai, Akira Yamauchi, Futoshi Kuribayashi. Redox Biology, Volume 56, October 2022, 102479. 08/12/2022. https://doi.org/10.1016/j.redox.2022.102479

Additional Search Phrases:

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 SDS    Datasheet

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m-dPEG®₂₄-MAL

$275.00 – $850.00

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PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
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m-dPEG®24-MAL, product number 10319, is a thiol-reactive, monodispersed PEGylation reagent used for surface and biomolecule modification. One end of the PEG molecule is methyl-terminated. The opposite end possesses a 3-maleimido propanoic acid functional group that connects to the PEG spacer via an amide bond. The maleimide moiety reacts with sulfhydryl groups by the thiol-Michael addition reaction.

PEGylation with dPEG® Reagents

Quanta BioDesign’s single molecular weight, discrete-chain-length PEGylation reagents (we sell them under the dPEG® tradename) are different from traditional PEGylation reagents.

Most conventional PEGylation reagents are non-uniform (i.e., disperse) polymers. In contrast, Quanta BioDesign’s dPEG® PEGylation reagents have no dispersity (Ð = 1).

Many monodisperse PEGylation reagents are purified from complex polymerization reactions. Contradistinctively, Quanta BioDesign’s dPEG® products are synthesized from high-purity, uniform glycol starting materials. Thus, they are superior in quality to many monodisperse PEG products.

Quanta BioDesign’s dPEG® products provide all of the benefits of conventional PEGylation reagents. However, because our products have no dispersity, they afford the user a more straightforward analysis of conjugates made from them.

Learn more about Quanta BioDesign’s dPEG® Technology!

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

How do I use m-dPEG®24-MAL?

m-dPEG®24-MAL modifies surfaces and biomolecules containing free thiol (sulfhydryl) groups using standard maleimide chemistry. m-dPEG®24-MAL is amphiphilic. It dissolves in aqueous buffers and organic solvents such as acetonitrile, dichloromethane, DMSO, DMF, and N, N-dimethylacetamide (DMAC).

The maleimide-thiol reaction is quite fast. At pH 6.5 – 7.5, it is highly specific for sulfhydryl groups. To learn more about the thiol-Michael addition, please click this link.

Published scientific reports using m-dPEG®24-MAL include the following:

  • Modifying surface-accessible free thiols on enzymes to probe enzymatic function;
  • Developing a virus-based drug delivery system; and,
  • Developing probes of cellular redox reactions.

Can Quanta BioDesign Manufacture m-dPEG®24-MAL in Bulk Quantities?

Yes, we can. If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Buy m-dPEG®24-MAL Today!

This non-immunogenic dPEG® product is a unique offering from Quanta BioDesign, Ltd. It improves the water solubility and increases the hydrodynamic volume of conjugates made with it. Buy it today and see what you can do with it. Click the “Add to Cart” button now to get started.

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Description

 

 

 

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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