Specs:

 SDS

Molecular Weight: 588.68; single compound

CAS: 117786-94-4

Purity: > 98%

Spacers: dPEG® Spacer is 38 atoms and 44.0 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

New optical probes for the continuous monitoring of renal function. Richard B. Dorshow, Bethel Asmelash, Lori K. Chinen, Martin P. Debreczeny, Richard M. Fitch, John N. Freskos, Karen P. Galen, Kimberly R. Gaston, Timothy A. Marzan, Amruta R. Poreddy, Raghavan Rajagopalan, Jeng-Jong Shieh, William L. Neumann. Proc. SPIE 6867, Molecular Probes for Biomedical Applications II. 2008. 68670C. February 13,2008. doi:10.1117/12.763697.




Additional Search Phrases:

PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, chemical modification reagent, chemical modification reagents, amine reactive, methoxy, methoxy capped, methoxy terminated, carboxylic acid, PEG acid, m-PEG, mPEG, mPEG acid, PEG12, m-PEG12-acid, mPEG12-COOH, mPEG600-acid, mPEG-acid



 SDS    Datasheet

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m-dPEG®₁₂-acid

$175.00 – $515.00

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PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10328 Categories: , Tags: , , , , , , , , , , , , , , , ,

m-dPEG®12-acid, product number 10328, is a medium-length, methyl-capped, discrete chain length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule terminates in a propionic acid group. This product also is the precursor to PN10262, m-dPEG®12-NHS ester and to PN10306, m-dPEG®12-TFP ester. In addition, m-dPEG®12-acid is part of a line of methyl-terminated dPEG® spacers. The dPEG® spacer lengths range from 2 to 49 ethylene glycol units.

The terminal propionic acid moiety can be coupled directly to free amines using EDC or another carbodiimide. Otherwise, the reactive end can be converted into an active ester that can then be conjugated to free amines. N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), and 2,3,4,5,6-pentafluorophenol (PFP) typically are used for this purpose.

m-dPEG®12-acid can modify amine-functionalized surfaces (carbon nanotubes, other nanoparticles, quantum dots, etc.) or free amines on biomolecules. In published scientific reports, m-dPEG®12-acid has been used to create optical probes and to study the system pharmacokinetics of poly-L-lysine dendrimers. When used to coat surfaces or modify biomolecules, m-dPEG®12-acid reduces or eliminates non-specific binding and increases water solubility. Please note that modifying the surface amines of biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.

Quanta BioDesign, Ltd., makes and sells single molecular weight PEG linkers and spacers with discrete chain lengths under the dPEG® trade name. Our products are distinctly different from traditional PEG products in that they are not disperse polymers. However, they confer all of the benefits of traditional PEG products. To learn more about dPEG® products, please read our page What is dPEG®? Please also visit our Frequently Asked Questions page to get answers to the questions we answer most often.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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