Specs:

 SDS

Molecular Weight: 848.03; single compound

CAS: 879571-23-0

Purity: > 97%

Spacers: dPEG® Spacer is 38 atoms and 43.9 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.



Additional Search Phrases:

Amino-dPEG12-ODMT, Amino-Trityl, 879571230, PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, DNA, RNA, nucleic acid, trityl, dimethoxytrityl, carboxyl, active ester, reactive, chemistry of nucleic acids, modification of nucleic acids, Amino-PEG12-ODMT, NH2-PEG12-ODMT, H2N-PEG600-ODMT



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Amino-dPEG®₁₂-ODMT

$225.00 – $900.00

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PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10342 Categories: , ,

Product number 10342, amino-dPEG®12-ODMT, was designed for nucleic acid modification in applications where PEGylation improves the therapeutic or diagnostic profile.

Nucleic acid aptamers are single-stranded DNA or RNA oligonucleotide sequences of approximately 20 – 100 nucleotides that bind specific target molecules with high affinity1,2. Nucleic acid aptamers have low immunogenicity and can be synthesized chemically in large quantities (mg up to kg) at very high purity and much lower cost than antibodies or other biologically derived therapeutic molecules.1,3. Because of their high affinity for targeted molecules, nucleic acid aptamers have fewer off-target effects than antibodies1,2. These aptamers, however, are quickly excreted from the body due to their small size or are rapidly degraded by nucleases3,4. PEGylation protects nucleic acid aptamers from enzymatic degradation in vivo and can extend in vivo serum half-life of these aptamers by increasing the hydrodynamic volume1-4.

Following oligonucleotide synthesis, amino-dPEG®12-ODMT can be conjugated to phosphate groups on either end of the chain using water-soluble 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) chemistry. The 4,4′-dimethoxytrityl group can then be removed using a weak acid, such as dilute dichloroacetic acid, leaving the dPEG® linker terminated with a hydroxy group. Studies have shown that 3′ end capping (including PEGylation) helps the oligonucleotide chain resist nuclease degradation, while 5′ end PEGylation reduces renal clearance of the aptamer3.

Learn more!

What is dPEG®?

Frequently Asked Questions (for dPEG® products)

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Application References:

  1. Kedzierski, S.; Caltagirone, T.; Khoshnejad, M. Synthetic Antibodies: The Emerging Field of Aptamers. BioProcessing Journal 2013, 11(4), 46–49. https://doi.org/10.12665/J114.KedzierskiCaltagirone.
  2. Röthlisberger, P.; Gasse, C.; Hollenstein, M. Nucleic Acid Aptamers: Emerging Applications in Medical Imaging, Nanotechnology, Neurosciences, and Drug Delivery. International Journal of Molecular Sciences 2017, 18(11), 2430. https://doi.org/10.3390/ijms18112430.
  3. Ni, S.; Yao, H.; Wang, L.; Lu, J.; Jiang, F.; Lu, A.; Zhang, G. Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes. International Journal of Molecular Sciences 2017, 18(8), 1683. https://doi.org/10.3390/ijms18081683.
  4. Becker, R.; Povsic, T.; Cohen, M. G.; Rusconi, C.; Sullenger, B. Nucleic Acid Aptamers as Antithrombotic Agents: Opportunities in Extracellular Therapeutics. Thromb Haemost 2010, 103 (3), 586–595. https://doi.org/10.1160/TH09-10-0716.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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