Specs:

 SDS

Molecular Weight: 742.94; single compound

CAS: 1224728-09-9

Spacers: dPEG® Spacer is 49 atoms and 57.1 Å

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation – Application on y-Secretase. Sophia Schedin-Weiss, Mitsuhiro Inoue, Yasuhiro Teranishi, Natsuko Goto Yamamoto, Helena Karlstrom, Bengt Winblad, Lars O. Tjernberg. PLoS ONE 2013, 8 (5) e63962. May 24, 2013. DOI:10.1371/journal.pone.0063962.

Teranishi, Y.; Hur, J.-Y.; Welander, H.; Frånberg, J.; Aoki, M.; Winblad, B.; Frykman, S.; Tjernberg, L. O. Affinity Pulldown of γ-Secretase and Associated Proteins from Human and Rat Brain. Journal of Cellular and Molecular Medicine 2010, 14 (11), 2675–2686. https://doi.org/10.1111/j.1582-4934.2009.00907.x.

Teranishi, Y. Identification and Investigation of Gamma-Secretase Associated Proteins from Brain. Doctoral Dissertation, Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society: Stockholm, Sweden, 2012.


Additional Search Phrases: Diamido-dPEG11-diamine, 1224728099, PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, amine, diamine, monoprotected diamine, homobifunctional, carboxyl reactive, cross linker, crosslinker, crosslinking reagent

Diamido-dPEG®₁₁-diamine

$150.00 – $800.00

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Product#: 10361 Categories: , , Tags: , , , , , , , , , , , ,

Diamido-dPEG®11-diamine, product number 10361, is a homobifunctional, water-soluble crosslinker. Both ends of the crosslinker terminate with amino groups. Carboxyl groups react with the crosslinker’s amines to form stable amide bonds. Aldehydes and ketones react to form Schiff bases. Reduce Schiff bases to secondary amines for improved bond stability. The cross-bridge of this molecule consists of a single molecular weight, discrete chain length polyethylene glycol (dPEG®) linker. The dPEG® linker is 49 atoms long and spans a distance of 57.1 Å. This molecule is useful for modifying carboxylic acid-functionalized surfaces, small molecules with reactive carbonyl groups, and carbohydrates containing reducing sugars.

PEGylation with dPEG® Products

Quanta BioDesign’s dPEG® technology produces single molecular weight polyethylene glycol chains of discrete length. Unlike traditional PEG products, our dPEG® products have no dispersity. Each dPEG® product contains only one chain length and molecular weight of PEG. Quanta BioDesign pioneered this technology over 20 years ago. Today, we remain the leading innovator and manufacturer of discrete PEG products. For a thorough discussion of our dPEG® technology, please click here. We answer our most frequently asked questions here.

Uses of Diamido-dPEG®11-diamine

The use of Diamido-dPEG®11-diamine appears in several patents. Moreover, researchers at the Karolinska Institutet, Stockholm, Sweden, reported the use of Diamido-dPEG®11-diamine in an investigation of γ-secretase and its role in Alzheimer’s Disease.

Furthermore, Diamido-dPEG®11-diamine may prove useful in the following applications:

  • Crosslinking peptides or other small biomolecules using available carboxylic acids, aldehydes, or ketones;
  • Introducing a dPEG® amine onto reducing sugars of a glycoprotein’s carbohydrate coat;
  • Passivating nanoparticle surfaces coated with carboxylic acids or their active esters; and,
  • Adding a medium-length dPEG® amine at the carboxyl terminus of a peptide.

Bulk Scale Production of Diamido-dPEG®11-diamine is Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

What Are You Waiting For?

The world is full of inferior, hydrophobic crosslinkers. Quanta BioDesign’s Diamido-dPEG®11-diamine crosslinker is water-soluble, non-immunogenic, and highly pure. Stop using inferior crosslinkers! Click the “Add to Cart” button and start using a superior product for your next product R&D project.

Description

 

 

Additional information

Weight.5 oz
Dimensions.75 × .75 × 2 in

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