Specs:

 SDS

Molecular Weight: 846.92; single compound

CAS: 854753-78-9

Purity: > 98%

Spacers: dPEG® Spacer is 49 atoms and 56.0 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Kinetics of endophilin N-BAR domain dimerization and membrane interactions. Benjamin R. Capraro, Zheng Shi, Tingting Wu, Zhiming Chen, Joanna M. Dunn, Elizabeth Rhoades, Tobias Baumgart. Journal of Biological Chemistry. 2013, 288 (11) March 12, 2013. DOI: 10.1074/jbc.M112.435511.

Enhanced Fluorescence resonance energy transfer immunoassay with improved sensitivity based on the Fab’-based immunoconjugates. Yoshiyuki Ohiro, Hiroshi Ueda, Norio Shibata, Teruyuki Nagamune. Analytical Biochemistry. 2007, 360 (2) pp 266-272. January 15, 2007. DOI: 10.1016/j.ab.2006.10.025.

X-ray Photoelectron Spectroscopy and Differential Capacitance Study of Thiol-Functional Polysiloxane Films on Gold Supports. Patrick A. Johnson and Rastislav Levicky. Langmuir. 2004, 20 (22) pp 9621-9627. September 28, 2004. DOI: 10.1021/la048458s.

Polymercaptosiloxane Anchor Films for Robust Immobilization of Biomolecules to Gold Supports. Patrick A. Johnson and Rastislav Levicky. Langmuir . 2003, 19 (24) pp10288-10294. October 30, 2003. DOI: 10.1021/la035102s.

Unfolding Mechanisms and Conformational Stability of the Dimeric Endophilin N-BAR Domain. Rui Jin, Michael Grasso, Mingyang Zhou, Ronen Marmorstein, and Tobias Baumgart. ACS Omega. 2021, Volume 6 Issue 32. 08/04/2021. DOI: 10.1021/acsomega.1c01905.


Additional Search Phrases:

Bis-MAL-dPEG11, Bis-Mal, 854753789, PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, crosslinker, cross linker, crosslinking reagent, amine reactive, homobifunctional, maleimide, maleimido, thiol, thiol reactive, bis-maleimide, bis-MAL, PEG3, Bis-MAL-PEG11 MAL-PEG11-MAL, Bis-maleimide-PEG11, Bis-maleimide-PEG500, Bis-maleimide-PEG



 SDS    Datasheet

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Bis-MAL-dPEG®₁₁

$225.00 – $1,200.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10397 Categories: , ,

Bis-MAL-dPEG®11, product number 10397, is a medium-length, homobifunctional, crosslinking reagent that links two molecules (e.g., peptides, proteins) together via the thiol-maleimide reaction (also known as the thiol-Michael addition). The ends of the molecule are both functionalized with maleimidopropionate groups. The two reactive ends are separated by a single molecular weight, discrete polyethylene glycol (dPEG®) spacer.

The thiol-maleimide reaction, a type of click chemistry reaction, is an extremely popular way to conjugate molecules. The maleimide functional group rapidly reacts with sulfhydryl groups, and the reaction is chemoselective for sulfhydryls in the pH range of 6.5 – 7.5. For details about the maleimide-thiol reaction, please visit our Maleimide Reaction Chemistry page. The polyethylene glycol (PEG) spacer between the two maleimide groups is a single molecular weight compound with a discrete chain length (thus the tradename dPEG®). This product is not made from a disperse polymer but is instead a single compound. For more information about Quanta BioDesign’s dPEG® technology, please click this link. Applications for this product include, among many others, studying cell internalization of crosslinked proteins; developing FRET immunoassays; and anchoring biomolecules to surfaces.

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Application References:

  1. Hermanson, G. T. Chapter 3, The Reactions of Bioconjugation. Bioconjugate Techniques, 3rd edition. Academic Press: New York, 2013, pages 229 – 258, particularly page 241, where Greg writes about the maleimide reactive group. Click here now for a review of Greg’s book and a link to purchase it.
  2. Hermanson, G. T. Chapter 18, PEGylation and Synthetic Polymer Modification. Bioconjugate Techniques, 3rd edition. Academic Press: New York, 2013, pages 787 – 838.
  3. Johnson, P. A.; Levicky, R. Polymercaptosiloxane Anchor Films for Robust Immobilization of Biomolecules to Gold Supports. Langmuir 2003, 19(24), 10288–10294. https://doi.org/10.1021/la035102s.
  4. Johnson, P. A.; Levicky, R. X-Ray Photoelectron Spectroscopy and Differential Capacitance Study of Thiol-Functional Polysiloxane Films on Gold Supports. Langmuir 2004, 20(22), 9621–9627. https://doi.org/10.1021/la048458s.
  5. Ohiro, Y.; Ueda, H.; Shibata, N.; Nagamune, T. Enhanced Fluorescence Resonance Energy Transfer Immunoassay with Improved Sensitivity Based on the Fab′-Based Immunoconjugates. Analytical Biochemistry 2007, 360(2), 266–272. https://doi.org/10.1016/j.ab.2006.10.025.
  6. Capraro, B. R.; Shi, Z.; Wu, T.; Chen, Z.; Dunn, J. M.; Rhoades, E.; Baumgart, T. Kinetics of Endophilin N-BAR Domain Dimerization and Membrane Interactions. J. Biol. Chem. 2013, 288(18), 12533–12543. https://doi.org/10.1074/jbc.M112.435511.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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