$250.00 – $1,300.00
NHS-dPEG®4-(m-dPEG®12)3 ester, product number 10401, is a water-soluble, amine-reactive, single molecular weight, branched PEGylation reagent. The core of this four-armed discrete PEG (dPEG®) product is tris. Three equal-length dPEG®12 branches terminate with methyl groups. A short dPEG®4 arm ends with an amine-reactive N-hydroxysuccinimidyl (NHS) ester. From the terminal carbonyl carbon of the dPEG®4 arm to each terminal methyl group on the dPEG®12 branches, the distance is 66 atoms (51.1 Å) long. This hydrophilic branched dPEG® product adds hydrodynamic volume to the conjugates, which reduces immunogenicity and renal clearance. Moreover, this product reduces or eliminates non-specific binding to conjugates and surfaces.