NHS-dPEG®₄-(m-dPEG®₁₂)₃-ester

$250.00$1,300.00

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PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses

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NHS-dPEG®4-(m-dPEG®12)3 ester, product number 10401, is a water-soluble, amine-reactive, single molecular weight, branched PEGylation reagent. The core of this four-armed discrete PEG (dPEG®) product is tris. Three equal-length dPEG®12 branches terminate with methyl groups. A short dPEG®4 arm ends with an amine-reactive N-hydroxysuccinimidyl (NHS) ester. From the terminal carbonyl carbon of the dPEG®4 arm to each terminal methyl group on the dPEG®12 branches, the distance is 66 atoms (51.1 Å) long. This hydrophilic branched dPEG® product adds hydrodynamic volume to the conjugates, which reduces immunogenicity and renal clearance. Moreover, this product reduces or eliminates non-specific binding to conjugates and surfaces.

PEGylation with dPEG® Products

Conventional PEGylation reagents are disperse polymers. With traditional PEG products, the stated molecular weight represents the average of a Poisson distribution of chain lengths and molecular weights of PEG. Dispersity complicates the analysis of conjugates made with these traditional PEGylation products.

Quanta BioDesign’s dPEG® products have no dispersity. In each product, there is a single, discrete length and molecular weight of the PEG chain. For this reason, we sell our products under the dPEG® tradename. Our dPEG® PEGylation reagents are superior to monodispersed PEG products because our products are synthesized from high-purity starting materials rather than purified out of a polymer mixture.

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Using NHS-dPEG®4-(m-dPEG®12)3 ester

The reaction chemistry for coupling a free amine to an NHS ester is standard in almost all bioconjugation labs worldwide. Numerous scientific publications attest to the benefits of NHS-dPEG®4-(m-dPEG®12)3 ester. These reports describe this product being used to:

  • Coat nanoparticle surfaces;
  • Create imaging applications;
  • Develop Antibody-Drug Conjugates (ADCs);
  • Modify PK and BD of biomolecular conjugates;
  • Prevent non-specific binding;
  • Passivate inorganic surfaces such as metal and diamond; and,
  • Develop hemerythrin-based blood substitutes.

Commercial Scale is Available for NHS-dPEG®4-(m-dPEG®12)3 ester

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Buy It Now!

NHS-dPEG®4-(m-dPEG®12)3 ester is a unique product from Quanta BioDesign. Its precise construction is possible only because we use single molecular weight dPEG® products. If you need a four-arm amine-reactive crosslinker with uniform molecular weight and structure, then you need NHS-dPEG®4-(m-dPEG®12)3 ester.

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Description

 

Additional information

Weight.5 oz
Dimensions.75 × .75 × 2 in
Size

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