Specs:

 SDS

Molecular Weight: 2420.80; single compound

CAS: 1334178-03-8

Purity: > 96%

Spacers: dPEG® Spacer is 66 atoms and 51.1 Å, avg.

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Towards the Development of Hemerythrin-Based Blood Substitutes. Augustin C. Mot, Alina Roman, Iulia Lupan , Donald M. Kurtz Jr , Radu Silaghi-Dumitrescu. Protein J. 2010, 29 (6) pp 87-393. June 27, 2010. DOI: 10.1007/s10930-010-9264-2.

Rapid Raman Imaging of Stable, Functionalized Nanoshells in Mammalian Cell Cultures. Yiming Huang, Vimal P. Swarup, Sandra Whaley Bishnoi. Nano Letters. 2009, 9 (8) pp 2914-2920. May 23, 2009. DOI: 10.1021/nl901234x.

Differential patterning of neuronal, glial and neural progenitor cells on phosphorus-doped and UV irradiated diamond-like carbon. Edward M. Regan, James B. Uney, Andrew D. Dick, Yiwei Zhang, Jose Nunez-Yanez, Joseph P. McGeehan, Frederik Claeyssens, Stephen Kelly. Biomaterials. 2010, 31 (2) pp 207-215. October 14, 2009. DOI: 10.1016/j.biomaterials.2009.09.042.

Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms. Marie Ranson, Paula Berghofer, Kara L. Vine, Ivan Greguric, Rachael Shepherd, Andrew Katsifis. Nuclear Medicine and Biology. 2012, 39 (6) pp 833-839. January 17, 2012. DOI: 10.1016/j.nucmedbio.2012.01.006.

Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Zhuang Liu, Corrine Davis, Weibo Cai, Lina He, Xiaoyuan Chen, and Hongjie Dai. PNAS. 2008, 105 (5) pp 1410-1415. February 5, 2008. DOI: 10.1073_pnas.0707654105.

Synthesis and Preliminary Biological Evaluation of High-Drug-Load Paclitaxel-Antibody Conjugates for Tumor-Targeted Chemotherapy. Sherly Quiles, Kevin P. Raisch, Leisa L. Sanford, James A. Bonner, and Ahmad Safavy. Journal of Medicinal Chemistry. 2009, 53 (2) pp 586-594. December 3, 2009. DOI: 10.1021/jm900899g.

TIRF microscopy as a screening method for non-specific binding on surfaces. Christy Charlton, Vladimir Gubala, Ram Prasad Gandhiraman, Julie Wiechecki, Nam Cao Hoai Le, Conor Coyle, Stephen Daniels, Brian D. MacCraith, David E. Williams. Journal of Colloid and Interface Science. 2011, 354 (1) pp 405-409. February 1, 2011. DOI: 10.1016/j.jcis.2010.10.029.

Influence of PEGylation with linear and branched PEG chains on the adsorption of glucagon to hydrophobic surfaces. Charlotte Pinholt , Jens Thostrup Bukrinsky, Susanne Hostrup, Sven Frokjaer, Willem Norde, Lene Jorgensen. European Journal of Pharmaceutics and Biopharmaceutics. 2010, 77 (1) pp 139–147. November 3, 2010. DOI: 10.1016/j.ejpb.2010.11.001.

The influence of polyethylence glycol structure on the conjugation of recombinant human interferon a2b overproduced using synthetic gene in E. coli. Heni Rachmawati, Prima L. Febrina, Ratih A, Ningrum, Debbie S. Retnoningrum. International Journal of Research in Pharmaceutical Sciences. 2012, 3(2) pp 228-233. March 20, 2012. ISSN: 0975-7538.

Monitoring Protein PEGylation with Ion Exchange Chromatography. Peter Yu, Deanna Hurum, Leo Wang, Terry Zhang,and Jeffrey Rohrer. ThermoFisher Scientific Poster Note. 2013, PN70510_E01/3s.

New Assay for Quantification of PEGylated Proteins During in Vitro Permeability Studies. Spela Jalen, Vanja Smilovic, Katarina Fidler, Barbara Podobnik, Maja Marusic, Radovan Komel, Vladka Gaberc-Porekar and Simona Jevsevar. Acta Chimica Slovenica. 2014, 61 (3) pp 615-622. January 15, 2014.

Nanometer size silicon particles for hyperpolarized MRI. Grzegorz Kwiatkowski, Fabian Jahnig, Jonas Steinhauser, Patrick Wespi, Matthias Ernst, and Sebastian Kozerke. Scientific Reports. 2017, 7 (7946) pp 1-9. August 11, 2017. DOI: 10.1038/s41598-017-08709-0.

Aptamer-Modified Nanohydrogel Microarrays for Bioselective Cancer Cell Immobilization. Zan Lamberger, Hendrik Bargel, Martin Humenik. Advanced Functional Materials, Volume 32, Issue 45 (2022). 08/28/22. https://doi.org/10.1002/adfm.202207270

Additional Search Phrases:

PEG, dPEG, discrete PEG, polyethylene glycol, poly (ethylene glycol), Quanta, Quanta BioDesign, PEGylation reagent, chemical modification reagent, chemical modification reagents, branched PEG, PEG4, PEG12, NHS, NHS ester, active ester, N-hydroxysuccinimide, amine reactive, NHS-PEG4-(m-PEG12)3-ester, NHS-PEG4-(PEG12-m)3, Succinimidyl-PEG4-(PEG12-m)3, (Methyl-PEG12)3-PEG4-NHS ester, TMS(PEG)12, Branched mPEG-NHS ester, TFP-PEG4-(m-PEG11)3 ester, TFP-PEG4-(PEG11-OMe)3, Branched mPEG-TFP ester



 SDS    Datasheet

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NHS-dPEG®₄-(m-dPEG®₁₂)₃-ester

$250.00 – $1,300.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10401 Categories: , Tags: , , , , , , , , , , , , , , , , ,

TFP_Esters_Art2

NHS-dPEG®4-(m-dPEG®12)3 ester, product number 10401, is a water-soluble, amine-reactive, single molecular weight, branched PEGylation reagent. The core of this four-armed discrete PEG (dPEG®) product is tris. Three equal-length dPEG®12 branches terminate with methyl groups. A short dPEG®4 arm ends with an amine-reactive N-hydroxysuccinimidyl (NHS) ester. From the terminal carbonyl carbon of the dPEG®4 arm to each terminal methyl group on the dPEG®12 branches, the distance is 66 atoms (51.1 Å) long. This hydrophilic branched dPEG® product adds hydrodynamic volume to the conjugates, which reduces immunogenicity and renal clearance. Moreover, this product reduces or eliminates non-specific binding to conjugates and surfaces.

PEGylation with dPEG® Products

Conventional PEGylation reagents are disperse polymers. With traditional PEG products, the stated molecular weight represents the average of a Poisson distribution of chain lengths and molecular weights of PEG. Dispersity complicates the analysis of conjugates made with these traditional PEGylation products.

Quanta BioDesign’s dPEG® products have no dispersity. In each product, there is a single, discrete length and molecular weight of the PEG chain. For this reason, we sell our products under the dPEG® tradename. Our dPEG® PEGylation reagents are superior to monodispersed PEG products because our products are synthesized from high-purity starting materials rather than purified out of a polymer mixture.

Learn more!

Using NHS-dPEG®4-(m-dPEG®12)3 ester

The reaction chemistry for coupling a free amine to an NHS ester is standard in almost all bioconjugation labs worldwide. Numerous scientific publications attest to the benefits of NHS-dPEG®4-(m-dPEG®12)3 ester. These reports describe this product being used to:

  • Coat nanoparticle surfaces;
  • Create imaging applications;
  • Develop Antibody-Drug Conjugates (ADCs);
  • Modify PK and BD of biomolecular conjugates;
  • Prevent non-specific binding;
  • Passivate inorganic surfaces such as metal and diamond; and,
  • Develop hemerythrin-based blood substitutes.

Commercial Scale is Available for NHS-dPEG®4-(m-dPEG®12)3 ester

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Buy It Now!

NHS-dPEG®4-(m-dPEG®12)3 ester is a unique product from Quanta BioDesign. Its precise construction is possible only because we use single molecular weight dPEG® products. If you need a four-arm amine-reactive crosslinker with uniform molecular weight and structure, then you need NHS-dPEG®4-(m-dPEG®12)3 ester.

Click the “Add to Cart” button now to purchase this product.

Description

 

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in
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