MAL-dPEG®4-(m-dPEG®12)3, PN 10406, is a thiol-reactive, branched, monodisperse PEG product that can modify the performance and distribution of biologic drugs. This single molecular weight, discrete-length PEG (dPEG®) product consists of a tris core from which branch three methyl-terminated dPEG®12 arms and one maleimide-functionalized dPEG®4 arm. From the reactive site on the maleimido group to the terminal methyl moiety on each of the dPEG®12 branches, the dPEG® spacer is 67 atoms (75.8 Å). This unique branched dPEG® construct increases the water solubility and hydrodynamic volume of conjugates that incorporate it. Also, MAL-dPEG®4-(m-dPEG®12)3 can reduce or eliminate immunogenicity and non-specific, hydrophobic interactions.

What is dPEG®?

Quanta BioDesign, Ltd. sells monodisperse polyethylene glycol (PEG) products under the dPEG® tradename. Unlike traditional PEGylation reagents, our dPEG® products have no dispersity because they are not polymerized but instead are built stepwise from high purity starting materials. Each dPEG® product contains a single molecular weight and discrete chain length of PEG. Discrete PEG products are far simpler to analyze and characterize than disperse PEG polymers that contain a mixture of different PEG chain lengths and molecular weights. A more straightforward analysis saves our customers time and money.

To learn more about Quanta BioDesign’s dPEG® products and technology, please visit the pages linked below.

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

How can I use MAL-dPEG®4-(m-dPEG®12)3?

MAL-dPEG®4-(m-dPEG®12)3 is best used to modify proteins, peptides, and other large biomolecules. Maleimide reacts with free thiols that occur in such molecules. The thiol-maleimide reaction is rapid and specific within the optimal pH range (6.5 – 7.5). For more information on the thiol-maleimide reaction, please visit our page “Maleimide Reaction Chemistry.”

Scientific publications report using MAL-dPEG®4-(m-dPEG®12)3 several times. These uses include probing protein structure and function, PEGylating cell surfaces, and dissecting protein-protein interactions. The reference work Bioconjugate Techniques, 3rd edition, by Greg T. Hermanson, contains specific protocols for the maleimide-thiol reaction. Quanta BioDesign sells this book and encourages our customers to use it.

Bulk quantities of MAL-dPEG®4-(m-dPEG®12)3 are available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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