Specs:

 SDS

Molecular Weight: 2360.75

CAS: 1334178-05-0

Purity: > 96%

Spacers: dPEG® Spacer is 67 atoms and 75.8 Å, Avg.

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Chapter 1, p. 30.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Enzymatic Deglutathionylation to Generate Interleukin-4 Cysteine Muteins with Free Thiol. Viswanadham Duppatla, Maja Gjorgjevikj, Werner Schmitz, Mathias Kottmair, Thomas D. Mueller, and Walter Sebald. Bioconjugate Chem., 2012, 23 (7), pp 1396–1405 June 9, 2012. DOI: 10.1021/bc2004389.

Inactivation by oxidation and recruitment into stress granules of hOGG1 but not APE1 in human cells exposed to sub-lethal concentrations of cadmium. Anne Bravard, Anna Campalans, Monique Vacher, Barbara Gouget, Céline Levalois, Sylvie Chevillard, J. Pablo Radicella. Mutation Research. 2010, 685 (1-2) pp 61-69. October 2, 2009. DOI: 10.1016/j.mrfmmm.2009.09.013.

Surface Location of Individual Residues of SlpA Provides Insight into the Lactobacillus brevis S-Layer. Heikki Vilen, Ulla Hynönen, Helga Badelt-Lichtblau, Nicola Ilk, Pentti Jääskeläinen, Mika Torkkeli and Airi Palva. J. Bacteriol. 2009, 191 (10) pp 3339-3351. March 20, 2009. DOI: 10.1128/JB.01782-08.

Dissecting Molecular Interactions Involved in Recognition of Target Disulfides by the Barley Thioredoxin System. Olof Bjornberg, Kenji Maeda, Birte Svensson, and Per Hagglund. Biochemistry. 2012, 51 (49) pp 9930-9939. November 19, 2012. DOI: 10.1021/bi301051b.

The Chloroplast Twin Arginine Transport (Tat) Component, Tha4, Undergoes Conformational Changes Leading to Tat Protein Transport. Cassie Aldridge, Amanda Storm, Kenneth Cline and Carole Dabney-Smith. J. Biol. Chem. 2012, 287 (1) pp 34752-34763. August 15, 2012. DOI: 10.1074/jbc.M112.385666.

Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress. Heather M. Tyra, Douglas R. Spitz, and D. Thomas Rutkowski. Molecular Biology of the Cell. 2012, 23 (5) pp 811-819. March 1, 2012. DOI: 10.1091/mbc.E11-12-1011.

Oxidation Status of Human OGG1-S326C Polymorphic Variant Determines Cellular DNA Repair Capacity. Anne Bravard, Monique Vacher, Eva Moritz,Laurence Vaslin, Janet Hall,Bernd Epe,and J. Pablo Radicella. Cancer Research.2009, 69 (8) pp 3642-3649.April 7, 2009. DOI: 10.1158/0008-5472.CAN-08-3943.

Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties. Furukawa Y, Kaneko K, Nukina N. . The Journal of Biological Chemistry. 2011, 286 (31) pp 27236-46. June 9, 2011. DOI: 10.1074/jbc.M111.248963.

Type IV Pilus Secretins Have Extracellular C Termini. Joshua A. Lieberman, Courtney D. Petro, Stefani Thomas, Austin Yang and Michael S. Donnenberga. mBio. 2015, 6(2) pp 1-13. March 24, 2015. DOI: 10.1128/mBio.00322-15.

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change. Vicky Howe, Ngee Kiat Chua, Julian Stevenson, and Andrew J. Brown. The Journal of Biological Chemistry. 2015, 290 (42). October 3, 2015. DOI: 10.1074/jbc.M115.675181.

Development of Raman Spectroscopy as a clinical Diagnostic Tool. Santa Borel. Tspace. 2016, pp 1-99. November 2016. http://hdl.handle.net/1807/74538.




Additional Search Phrases:

PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, maleimide, maleimido, thiol reactive, sulfhydryl reactive, branched PEG, chemical modification reagent, chemical modification reagents, methoxy terminated, methoxy-terminated, MAL-PEG4-(m-PEG12)3, Maleimide-PEG4-(PEG12-m)3, Branched mPEG-maleimide



 SDS    Datasheet

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MAL-dPEG®₄-(m-dPEG®₁₂)₃

$250.00 – $1,300.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10406 Categories: , Tags: , , , , , , , , , , , , , , ,

MAL-dPEG®4-(m-dPEG®12)3, PN 10406, is a thiol-reactive, branched, monodisperse PEG product that can modify the performance and distribution of biologic drugs. This single molecular weight, discrete-length PEG (dPEG®) product consists of a tris core from which branch three methyl-terminated dPEG®12 arms and one maleimide-functionalized dPEG®4 arm. From the reactive site on the maleimido group to the terminal methyl moiety on each of the dPEG®12 branches, the dPEG® spacer is 67 atoms (75.8 Å). This unique branched dPEG® construct increases the water solubility and hydrodynamic volume of conjugates that incorporate it. Also, MAL-dPEG®4-(m-dPEG®12)3 can reduce or eliminate immunogenicity and non-specific, hydrophobic interactions.

What is dPEG®?

Quanta BioDesign, Ltd. sells monodisperse polyethylene glycol (PEG) products under the dPEG® tradename. Unlike traditional PEGylation reagents, our dPEG® products have no dispersity because they are not polymerized but instead are built stepwise from high purity starting materials. Each dPEG® product contains a single molecular weight and discrete chain length of PEG. Discrete PEG products are far simpler to analyze and characterize than disperse PEG polymers that contain a mixture of different PEG chain lengths and molecular weights. A more straightforward analysis saves our customers time and money.

To learn more about Quanta BioDesign’s dPEG® products and technology, please visit the pages linked below.

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

How can I use MAL-dPEG®4-(m-dPEG®12)3?

MAL-dPEG®4-(m-dPEG®12)3 is best used to modify proteins, peptides, and other large biomolecules. Maleimide reacts with free thiols that occur in such molecules. The thiol-maleimide reaction is rapid and specific within the optimal pH range (6.5 – 7.5). For more information on the thiol-maleimide reaction, please visit our page “Maleimide Reaction Chemistry.”

Scientific publications report using MAL-dPEG®4-(m-dPEG®12)3 several times. These uses include probing protein structure and function, PEGylating cell surfaces, and dissecting protein-protein interactions. The reference work Bioconjugate Techniques, 3rd edition, by Greg T. Hermanson, contains specific protocols for the maleimide-thiol reaction. Quanta BioDesign sells this book and encourages our customers to use it.

Bulk quantities of MAL-dPEG®4-(m-dPEG®12)3 are available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Buy it now!

Discover the dPEG® difference. Click the “Add to Cart” button now to order MAL-dPEG®4-(m-dPEG®12)3.

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