MAL-dPEG®₄-(m-dPEG®₁₂)₃

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PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses

MAL-dPEG®4-(m-dPEG®12)3, PN 10406, is a thiol-reactive, branched, monodisperse PEG product that can modify the performance and distribution of biologic drugs. This single molecular weight, discrete-length PEG (dPEG®) product consists of a tris core from which branch three methyl-terminated dPEG®12 arms and one maleimide-functionalized dPEG®4 arm. From the reactive site on the maleimido group to the terminal methyl moiety on each of the dPEG®12 branches, the dPEG® spacer is 67 atoms (75.8 Å). This unique branched dPEG® construct increases the water solubility and hydrodynamic volume of conjugates that incorporate it. Also, MAL-dPEG®4-(m-dPEG®12)3 can reduce or eliminate immunogenicity and non-specific, hydrophobic interactions.

What is dPEG®?

Quanta BioDesign, Ltd. sells monodisperse polyethylene glycol (PEG) products under the dPEG® tradename. Unlike traditional PEGylation reagents, our dPEG® products have no dispersity because they are not polymerized but instead are built stepwise from high purity starting materials. Each dPEG® product contains a single molecular weight and discrete chain length of PEG. Discrete PEG products are far simpler to analyze and characterize than disperse PEG polymers that contain a mixture of different PEG chain lengths and molecular weights. A more straightforward analysis saves our customers time and money.

To learn more about Quanta BioDesign’s dPEG® products and technology, please visit the pages linked below.

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

How can I use MAL-dPEG®4-(m-dPEG®12)3?

MAL-dPEG®4-(m-dPEG®12)3 is best used to modify proteins, peptides, and other large biomolecules. Maleimide reacts with free thiols that occur in such molecules. The thiol-maleimide reaction is rapid and specific within the optimal pH range (6.5 – 7.5). For more information on the thiol-maleimide reaction, please visit our page “Maleimide Reaction Chemistry.”

Scientific publications report using MAL-dPEG®4-(m-dPEG®12)3 several times. These uses include probing protein structure and function, PEGylating cell surfaces, and dissecting protein-protein interactions. The reference work Bioconjugate Techniques, 3rd edition, by Greg T. Hermanson, contains specific protocols for the maleimide-thiol reaction. Quanta BioDesign sells this book and encourages our customers to use it.

Bulk quantities of MAL-dPEG®4-(m-dPEG®12)3 are available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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