NHS-dPEG®₄-(m-dPEG®₈)₃-ester

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NHS-dPEG®4-(m-dPEG®8)3 ester, product number 10421, is a water-soluble, amine-reactive, single molecular weight, branched PEGylation reagent. This four-armed discrete PEG (dPEG®) product is built around a tris core. A short dPEG®4 arm ends with an N-hydroxysuccinimide (NHS) ester. Three equal-length dPEG®8 branches terminate with methyl groups. The distance from the terminal carbonyl carbon of the dPEG®4 arm to the terminal methyl group on each of the dPEG®8 branches is 55 atoms (60.2 Å). This hydrophilic, branched dPEG® product increases the conjugates’ water solubility and hydrodynamic volume. Conjugates also may display reduced immunogenicity, diminished renal clearance, and lowered non-specific hydrophobic interactions.

PEGylation with dPEG® Products

Conventional PEGylation reagents are disperse polymers. With traditional PEG products, the stated molecular weight represents the average of a Poisson distribution of chain lengths and molecular weights of PEG. Dispersity complicates the analysis of conjugates made with these traditional PEGylation products.

Quanta BioDesign’s dPEG® products have no dispersity. In each product, there is a single, discrete length and molecular weight of the PEG chain. For this reason, we sell our products under the dPEG® tradename. Our dPEG® PEGylation reagents are superior to other monodisperse PEG products because our products are synthesized from high-purity starting materials rather than purified out of a polymer mixture.

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Using NHS-dPEG®4-(m-dPEG®8)3 ester

The reaction chemistry between the NHS ester and a free amine is standard in almost all bioconjugation labs. NHS-dPEG®4-(m-dPEG®8)3 ester can be used for:

  • Coating nanoparticle surfaces;
  • Creating imaging applications;
  • Developing Antibody-Drug Conjugates (ADCs);
  • Modifying PK and BD of biomolecular conjugates;
  • Preventing non-specific hydrophobic interactions; and,
  • Passivating amine-functionalized inorganic surfaces such as metal and diamond.

Commercial Scale is Available for NHS-dPEG®4-(m-dPEG®8)3 ester

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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NHS-dPEG®4-(m-dPEG®8)3 ester is a unique chemical modification reagent from Quanta BioDesign. Its precise construction is possible only because we use single molecular weight dPEG® products. If you need a four-arm amine-reactive crosslinker with uniform molecular weight and structure, then you need NHS-dPEG®4-(m-dPEG®8)3 ester.

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in