NHS-dPEG®₄-(m-dPEG®₈)₃-ester

$250.00$1,300.00

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PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses

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NHS-dPEG®4-(m-dPEG®8)3 ester, product number 10421, is a water-soluble, amine-reactive, single molecular weight, branched PEGylation reagent. This four-armed discrete PEG (dPEG®) product is built around a tris core. A short dPEG®4 arm ends with an N-hydroxysuccinimide (NHS) ester. Three equal-length dPEG®8 branches terminate with methyl groups. The distance from the terminal carbonyl carbon of the dPEG®4 arm to the terminal methyl group on each of the dPEG®8 branches is 55 atoms (60.2 Å). This hydrophilic, branched dPEG® product increases the conjugates’ water solubility and hydrodynamic volume. Conjugates also may display reduced immunogenicity, diminished renal clearance, and lowered non-specific hydrophobic interactions.

PEGylation with dPEG® Products

Conventional PEGylation reagents are disperse polymers. With traditional PEG products, the stated molecular weight represents the average of a Poisson distribution of chain lengths and molecular weights of PEG. Dispersity complicates the analysis of conjugates made with these traditional PEGylation products.

Quanta BioDesign’s dPEG® products have no dispersity. In each product, there is a single, discrete length and molecular weight of the PEG chain. For this reason, we sell our products under the dPEG® tradename. Our dPEG® PEGylation reagents are superior to other monodisperse PEG products because our products are synthesized from high-purity starting materials rather than purified out of a polymer mixture.

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Using NHS-dPEG®4-(m-dPEG®8)3 ester

The reaction chemistry between the NHS ester and a free amine is standard in almost all bioconjugation labs. NHS-dPEG®4-(m-dPEG®8)3 ester can be used for:

  • Coating nanoparticle surfaces;
  • Creating imaging applications;
  • Developing Antibody-Drug Conjugates (ADCs);
  • Modifying PK and BD of biomolecular conjugates;
  • Preventing non-specific hydrophobic interactions; and,
  • Passivating amine-functionalized inorganic surfaces such as metal and diamond.

Commercial Scale is Available for NHS-dPEG®4-(m-dPEG®8)3 ester

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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NHS-dPEG®4-(m-dPEG®8)3 ester is a unique chemical modification reagent from Quanta BioDesign. Its precise construction is possible only because we use single molecular weight dPEG® products. If you need a four-arm amine-reactive crosslinker with uniform molecular weight and structure, then you need NHS-dPEG®4-(m-dPEG®8)3 ester.

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Additional information

Weight.5 oz
Dimensions.75 × .75 × 2 in