Specs:

 SDS

Molecular Weight: 219.24; single compound

CAS: 86770-67-4

Purity: > 98%

Spacers: dPEG® Spacer is 14 atoms and 15.3 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Additional Search Phrases:

Azido-dPEG4-OH, hydroxy azide, N3-OH, 86770674, PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, azide, azide ion, azido, azido group, click chemistry, click reagent, Huisgen cycloaddition, alcohol, hydroxy, PEG spacer, carboxyl, extend carboxyl, azido alcohol, azido PEG8, azido-dPEG8-alcohol, azido PEG8 alcohol, N3-PEG8-OH, click chemistry tools, crosslinker, N3 PEG400, Azido PEG400, Azido-PEG4-alcohol, N3-PEG4-OH, PEG4-azide, Hydroxy-PEG-azide



 SDS    Datasheet

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Azido-dPEG®₄-OH

$100.00 – $150.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10541 Categories: ,

Azido-dPEG®4-OH (Azido-dPEG®4-alcohol), product number 10541, is a click chemistry reagent used to modify surfaces and biomolecules or to crosslink with other surfaces or biomolecules. This product consists of an azide and a terminal hydroxy group separated by a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. The terminal azide reacts in copper(I)-catalyzed, ruthenium-catalyzed, and strain-promoted azide-alkyne cycloaddition reactions (CuAAC, RuAAC, and SPAAC, respectively). If left unmodified, the alcohol group increases the water solubility and hydrodynamic volume of molecules and surfaces to which it is conjugated. Modifying the alcohol with a reactive group such as chloride, tosylate, or mesylate allows Azido-dPEG®4-OH to function as a crosslinker through subsequent chemical manipulations.

Quanta BioDesign’s dPEG® Crosslinkers

Polyethylene glycol (PEG) products are widely renowned for the unique chemical and physical properties that they impart to conjugate molecules. These imparted properties include

  • increased hydrodynamic volume;
  • improved water solubility for hydrophobic small molecules and biomolecules;
  • reduced or eliminated hydrophobic and non-specific interactions that lead to background “noise” in diagnostic tests or aggregation and precipitation of biomolecular conjugates; and,
  • reduced or eliminated immunogenicity of large biomolecular conjugates.

Unlike polymeric PEG products, which contain a wide range of PEG chain lengths and molecular weights, Quanta BioDesign’s dPEG® products are unique. These are monodispersed PEG products made by careful, step-wise synthesis using synthetic organic chemistry methods. To learn more about our products, please visit the following pages:

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Using Azido-dPEG®4-OH

As a click chemistry reagent, azido-dPEG®4-OH can participate in CuAAC, RuAAC, and SPAAC reactions. Because Quanta BioDesign’s dPEG® products are amphiphilic, these reactions can occur almost equally well in water or organic solvents. Thus, azido-dPEG®4-OH can be used in conjugations with biomolecules where organic solvents may damage the conjugate target.

The primary alcohol group on the opposite end of the linker can be used as a neutrally charged functional group. In this function, the alcohol enhances the water solubility of the conjugate molecule. Alternatively, the alcohol group can be functionalized with reactive groups and used to modify the conjugate further.

Azido-dPEG®4-alcohol is available at commercial scale

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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To get started with your order of Azido-dPEG®4-OH, please click the “Add to Cart” button now.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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