Azido-dPEG®4-OH (Azido-dPEG®4-alcohol), product number 10541, is a click chemistry reagent used to modify surfaces and biomolecules or to crosslink with other surfaces or biomolecules. This product consists of an azide and a terminal hydroxy group separated by a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. The dPEG® chain is 14 atoms (15.3 Å) long. The terminal azide reacts in copper(I)-catalyzed, ruthenium-catalyzed, and strain-promoted azide-alkyne cycloaddition reactions (CuAAC, RuAAC, and SPAAC, respectively). If left unmodified, the alcohol group increases the water solubility and hydrodynamic volume of molecules and surfaces to which it is conjugated. Modifying the alcohol with a reactive group such as chloride, tosylate, or mesylate allows Azido-dPEG®4-OH to function as a crosslinker through subsequent chemical manipulations.
Quanta BioDesign’s dPEG® Crosslinkers
Polyethylene glycol (PEG) products are widely renowned for the unique chemical and physical properties that they impart to conjugate molecules. These imparted properties include
increased hydrodynamic volume;
improved water solubility for hydrophobic small molecules and biomolecules;
reduced or eliminated hydrophobic and non-specific interactions that lead to background “noise” in diagnostic tests or aggregation and precipitation of biomolecular conjugates; and,
reduced or eliminated immunogenicity of large biomolecular conjugates.
Unlike polymeric PEG products, which contain a wide range of PEG chain lengths and molecular weights, Quanta BioDesign’s dPEG® products are unique. These are monodispersed PEG products made by careful, step-wise synthesis using synthetic organic chemistry methods. To learn more about our products, please visit the following pages:
As a click chemistry reagent, azido-dPEG®4-OH can participate in CuAAC, RuAAC, and SPAAC reactions. Because Quanta BioDesign’s dPEG® products are amphiphilic, these reactions can occur almost equally well in water or organic solvents. Thus, azido-dPEG®4-OH can be used in conjugations with biomolecules where organic solvents may damage the conjugate target.
The primary alcohol group on the opposite end of the linker can be used as a neutrally charged functional group. In this function, the alcohol enhances the water solubility of the conjugate molecule. Alternatively, the alcohol group can be functionalized with reactive groups and used to modify the conjugate further.
Azido-dPEG®4-alcohol is available at commercial scale
If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.
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