Specs:

 SDS

Molecular Weight: 400.53; single compound

CAS: 651042-83-0

Purity: > 98%

Spacers: dPEG® Spacer is 26 atoms and 30.0 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Biomarker-Mediated Disruption of Coffee-Ring Formation as a Low Resource Diagnostic Indicator. Joshua R. Trantum, David W. Wright, and Frederick R. Haselton, Langmuir, 2012, 28 (4), pp 2187–2193 December 9, 2011. DOI.org/10.1021/la203903a.

(INVITED)Quantitative detection of SARS-CoV-2 virions in aqueous mediums by IoT optical fiber sensors. Nunzio Cennamo, Girolamo D'Agostino, Laura Pasquardini, Francesco Arcadio, Chiara Perri, Nicola Coppola, Italo Francesco Angelillo, Lucia Altucci, Francesco Di Marzo, Eva Maria Parisio, Giulio Camarlinghi, Luigi Zeni. Science Direct. Volume 5. https://doi.org/10.1016/j.rio.2021.100177


Additional Search Phrases:

m-dPEG8-Thiol, 651042830, PEG, dPEG, discrete PEG, polyethylene glycol, poly (ethylene glycol), Quanta, Quanta BioDesign, PEGylation reagent, mPEG, m-PEG, methoxy PEG, mPEG-thiol, mPEG thiol, mPEG8, PEG8, metal surface modification reagent, surface modification reagent, surface modification, gold surface, gold surface, gold nanoparticle, chemical modification, chemical modification reagent, m-PEG8-thiol, mPEG8-SH, mPEG-thiol



 SDS    Datasheet

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m-dPEG®₈-Thiol

$200.00 – $575.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10793 Categories: ,

m-dPEG®8-thiol, PN 10793, is a monodisperse PEG that modifies gold and silver surfaces (e.g., nanoparticles) and molecules containing free thiols. A methyl group caps one end of the dPEG® chain, and a sulfhydryl functional group terminates the opposite end. The terminal thiol group forms disulfide bonds with other thiols, dative bonds with gold and silver, and thioether bonds with maleimides and bromoacetates.

PEGylation with dPEG® products

PEGylation increases water solubility and expands the hydrodynamic volume of conjugates. Also, PEGylation reduces immunogenicity, renal clearance, and non-specific interactions arising from hydrophobic regions on surfaces and biomolecules. Surface PEGylation prevents proteins and other biomolecules from binding non-specifically with the surface.

Traditional PEGylation reagents are disperse polymers. Such products consist of a variety of PEG chain lengths and molecular weights. When reacted with biomolecules, this complex mixture of PEG products leads to a muddled combination of conjugates that are difficult and time-consuming to analyze.

In contrast, Quanta BioDesign’s dPEG® products are monodisperse PEGylation reagents. These products are synthesized from high purity starting materials and have no dispersity (Ð = 1). Because there is a single PEG product, the conjugates formed are predictable and relatively straightforward to analyze.

Learn more about our dPEG® products!

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Using m-dPEG®8-thiol

m-dPEG®8-thiol reacts readily in non-oxidizing environments. In aqueous solution, care must be taken to exclude oxygen from the water by bubbling nitrogen or helium through the water. With biomolecules, it may be prudent to add a small amount of ethylenediaminetetraacetic acid (EDTA) to chelate any heavy metals that might be present as these could also promote oxidation. Greg Hermanson’s text, Bioconjugate Techniques, 3rd edition, contains protocols for reacting thiols with gold, silver, and biomolecules.

This product is suitable for passivating surfaces of gold or silver and for modifying biomolecules to improve performance and solubility. In scientific literature, m-dPEG®8-thiol has enhanced the performance of nanochromatography using the “coffee ring” effect, thereby providing a proof-of-principle demonstration of low resource detection of malaria biomarkers.

Bulk quantities are available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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