Specs:

 SDS

Molecular Weight: 634.77; single compound

CAS: 1032347-93-5

Purity: > 97%

Spacers: dPEG® Spacer is 39 atoms and 46.8 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Gold nanoparticle-based fluorescence quenching via metal coordination for assaying protease activity. Se Yeon Park, So Min Lee, Gae Baik, Kim and Young-Pil Kim. Gold Bull. 2012, 45 pp 213–219. October 25, 2012. DOI 10.1007/s13404-012-0070-9.

Systemically probing the bottom-up synthesis of AuPAMAM conjugates for enhanced transfection efficiency. Elizabeth R. Figueroa, Stephen Yan, Nicolette K. Chamberlain-Simon, Adam Y. Lin, Aaron E. Foster, and Rebekah A. Drezek. Journal of Nanobiotechnology. 2016, 14 (24). March 31, 2016. DOI: 10.1186/s12951-016-0178-9.

Modulating the Glucose Transport by Engineering Gold Nanoparticles. Sanjib Bhattacharyya, Krishna Kattel, and Franklin Kim. Journal of Nanomedicine and Biotherapeutic Discovery. 2016, 6 (1) pp 1-5. April 30, 2016. DOI: 10.4172/2155-983X.1000141.

Use of semiconductor nanocrystals to encode microbeads for multiplexed analysis of biological samples. Mikhail A Berestovoy, Regina S Bilan, Victor Krivenkov, Igor Nabiev, and Alyona Sukhanova. IOP Science. 2017, 784 (1) pp 1742-6596. March 15, 2017. DOI: 10.1088/1742-6596/784/1/012012.

Spectroscopy Based Approaches for Detection of Ions, Alpha-L-Fucosidase, and Singlet Oxygen. Eric Waidely. University of Miami Scholarly Repository. 2017, pp 1-113. May 3, 2017. http://scholarlyrepository.miami.edu/oa_dissertations/1842.

Near-Infrared-Activated Fluorescence Resonance Energy Transfer-Based Nanocomposite to Sense MMP2-Overexpressing Oral Cancer Cells. Yung-Chieh Chan, Ming-Hsien Chan, Chieh-Wei Chen, Ru-Shi Liu, Michael Hsiao, and Din Ping Tsai. ACS Omega. 2018,3 (2) pp. 1627-1634. February 8, 2018. DOI: 10.1021/acsomega.7b01494.

Signal enhancement of optical immunosensing by gold nanoparticles. Yuan Xintong. Nanyang Technological University, School of Material Science and Engineering Thesis for the degree of Master of Engineering. 2015, pp 1-74.

Biofunctionalized Polyelectrolyte Microcapsules Encoded with Fluorescent Semiconductor Nanocrystals for Highly Specific Targeting and Imaging of Cancer Cells. Galina Nifontova, Daria Kalenichenko, Maria Baryshnikova, Fernanda Ramos Gomes, Frauke Alves, Alexander Karaulov, Igor Nabiev, and Alyona Sukhanova. Advances on Applications of Optics and Photonics – Selected Papers from the 4th International Conference on Applications of Optics and Photonics, AOP2019. November 8, 2019. DOI: 10.3390/photonics6040117

NEW FRONTIERS FOR TRIPLE NEGATIVE BREAST CANCER DETECTION AND TREATMENT: FROM MECHANICAL BIOMARKERS TO SPECIFIC NANOPARTICLE ENTRY FOR ROBOTICALLY CONTROLLED LASER-INDUCED HYPERTHERMIA. Vanessa Uzonwanne. Worchester Polytechnic Institute. 2022. May 22, 2022.

SCORe: SARS-CoV-2 Omicron Variant RBD-Binding DNA Aptamer for Multiplexed Rapid Detection and Pseudovirus Neutralization. Lucy F. Yang, Nataly Kacherovsky, Joey Liang, Stephen J. Salipante, and Suzie H. Pun. Anal. Chem. 2022, 94, 37, 12683–12690. https://doi.org/10.1021/acs.analchem.2c01993

Additional Search Phrases:

Thiol-dPEG12-acid, 1032347935, PEG, dPEG, discrete PEG, polyethylene glycol, poly (ethylene glycol), Quanta, Quanta BioDesign, PEGylation reagent, thiol acid, thiol PEG acid, thiol-PEG-acid, thiol-PEG acid, chemical modification reagent, metal surface modification, metal surface modification reagent, gold surface, gold nanoparticle, dative bond, dative bonding, PEG12, Carboxy-​PEG12-​C2-​Thiol, Thiol-PEG12-acid, Thiol-PEG12-COOH, HS-PEG12-COOH, Carboxy-PEG12-Thiol, CT(PEG)12, Carboxy-PEG600-Thiol, Carboxy-PEG-Thiol



 SDS    Datasheet

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Thiol-dPEG®₁₂-acid

$250.00 – $875.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10850 Categories: ,

Thiol-dPEG®12-acid, product number 10850, is a single molecular weight, discrete-length polyethylene glycol (dPEG®) crosslinking PEGylation reagent. One end of the crosslinker terminates in a sulfhydryl (thiol) group. Propionic acid terminates the opposite end. The thiol end of the molecule forms dative bonds with gold. Moreover, it forms thioether bonds with maleimide and bromoacetate groups and disulfide bonds with other sulfhydryl groups. The propionic acid group reacts with amines to form amide bonds. Alternatively, if it is left unreacted, the propionic acid group provides a negative charge to the conjugated molecule or modified surface.

Quanta BioDesign’s dPEG® PEGylation Reagents

For over 20 years, Quanta BioDesign has designed, developed, and manufactured monodispersed PEGylation reagents. Unlike typical monodispersed PEGylation reagents, at Quanta BioDesign, we synthesize our products from high purity starting materials. All of our products have single molecular weights and discrete chain lengths (hence the tradename “dPEG®“). Even through multiple synthetic steps, our products retain a uniform composition. To learn more about dPEG® technology, please visit the two pages linked below:

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Using Thiol-dPEG®12-acid

Numerous scientific publications attest to the benefits of Thiol-dPEG®12-acid. Reports in the scientific literature describe the use of Thiol-dPEG®12-acid:

  • Assaying protease by using fluorescence quenching with gold nanoparticles;
  • Enhancing transfection efficiency;
  • Modulating glucose transport with gold nanoparticles;
  • Developing multiplexed bioassays on semiconductor gold nanocrystals;
  • Developing spectroscopy applications; and,
  • Detecting cancer through a FRET-based, NIR-activated system that uses gold nanoparticles.

Commercial Scale is Available for Thiol-dPEG®12-acid

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Buy It Now!

Thiol-dPEG®12-acid is a unique crosslinking product from Quanta BioDesign. Hydrophobic crosslinkers trigger aggregation and precipitation in aqueous buffers and lead to non-specific binding. Crosslinkers using dispersed PEG products create analytical complexities that are costly and challenging to overcome. You need a crosslinker that is superior to both hydrophobic crosslinkers and dispersed polymer crosslinkers. You need Thiol-dPEG®12-acid.

Click the “Add to Cart” button now to purchase this product.

Description

 

 

 

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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