Thiol-dPEG®12-acid, product number 10850, is a single molecular weight, discrete-length polyethylene glycol (dPEG®) crosslinking PEGylation reagent. One end of the crosslinker terminates in a sulfhydryl (thiol) group. Propionic acid terminates the opposite end. The thiol end of the molecule forms dative bonds with gold. Moreover, it forms thioether bonds with maleimide and bromoacetate groups and disulfide bonds with other sulfhydryl groups. The propionic acid group reacts with amines to form amide bonds. Alternatively, if it is left unreacted, the propionic acid group provides a negative charge to the conjugated molecule or modified surface.

Quanta BioDesign’s dPEG® PEGylation Reagents

For over 20 years, Quanta BioDesign has designed, developed, and manufactured monodispersed PEGylation reagents. Unlike typical monodispersed PEGylation reagents, at Quanta BioDesign, we synthesize our products from high purity starting materials. All of our products have single molecular weights and discrete chain lengths (hence the tradename “dPEG®“). Even through multiple synthetic steps, our products retain a uniform composition. To learn more about dPEG® technology, please visit the two pages linked below:

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Using Thiol-dPEG®12-acid

Numerous scientific publications attest to the benefits of Thiol-dPEG®12-acid. Reports in the scientific literature describe the use of Thiol-dPEG®12-acid:

  • Assaying protease by using fluorescence quenching with gold nanoparticles;
  • Enhancing transfection efficiency;
  • Modulating glucose transport with gold nanoparticles;
  • Developing multiplexed bioassays on semiconductor gold nanocrystals;
  • Developing spectroscopy applications; and,
  • Detecting cancer through a FRET-based, NIR-activated system that uses gold nanoparticles.

Commercial Scale is Available for Thiol-dPEG®12-acid

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Buy It Now!

Thiol-dPEG®12-acid is a unique crosslinking product from Quanta BioDesign. Hydrophobic crosslinkers trigger aggregation and precipitation in aqueous buffers and lead to non-specific binding. Crosslinkers using dispersed PEG products create analytical complexities that are costly and challenging to overcome. You need a crosslinker that is superior to both hydrophobic crosslinkers and dispersed polymer crosslinkers. You need Thiol-dPEG®12-acid.

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in