Specs:

 SDS

Molecular Weight: 1969.33; single compound

CAS: 924280-65-9

Purity: > 98%

Spacers: dPEG® Spacer is 115 atoms and 137.8 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, and the specific sample protocol for SPDP and LC-SPDP on pp. 286-288. See Greg’s extensive index on pp. 1192-1193 for references to a number and range of applications and their respective protocols.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Metronomic Doses of Temozolomide Enhance the Efficacy of Carbon Nanotube CpG Immunotherapy in an Invasive Glioma Model. Mao Ouyang, Ethan E. White, Hui Ren, Qin Guo, Ian Zhang, Hang Gao, Song Yanyan, Xuebo Chen, Yiming Weng, Anna Da Fonseca, Sunny Shah, Edwin R. Manuel, Leying Zhang, Steven L. Vonderfecht, Darya Alizadeh, Jacob M. Berlin, and Behnam Badie. PLoS One. 2016, 11 (2) e0148139. February 1, 2016. DOI: 10.1371/journal.pone.0148139.

Single-wavelength-excited fluorogenic nanoprobe for accurate realtime ratiometric analysis of broad pH fluctuations in mitophagy. Xin Zhang, Juan Chen, Jiwen Hu, Anna du Rietz, Xiongyu Wu, Ruilong Zhang, Zhongping Zhang, Kajsa Uvdal, Zhangjun Hu. Springer Link. 2022. May 11, 2022. doi.org/10.1007/s12274-022-4325-3



Additional Search Phrases:

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 SDS    Datasheet

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SPDP-dPEG®₃₆-NHS ester

$300.00 – $1,450.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 10867 Categories: ,

TFP_Esters_Art2

SPDP-dPEG®36-NHS ester, product number 10867, is an amphiphilic, water-soluble, monodispersed PEGylation reagent that is designed to crosslink amines and free thiols. SPDP (sometimes referred to as orthopyridyl disulfide, or OPSS, in the scientific literature) reacts with sulfhydryl groups to form disulfide bonds. The N-hydroxysuccinimidyl (NHS) ester reacts with free amines to form amide bonds.

PEGylation with Quanta BioDesign’s dPEG® Products

Quanta BioDesign’s single molecular weight, discrete chain length PEGylation reagents are quite different from traditional PEGylation reagents. Our products are not dispersed polymers, nor are they purified from polymeric mixtures. Instead, we synthesize all of our products from high-purity starting materials and maintain discrete chain lengths and single molecular weights throughout the entire synthetic process. To learn more about our products and technology, please visit our informational pages linked below.

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Crosslinking with SPDP

Among the most popular heterobifunctional crosslinking reagents used in bioconjugate chemistry are those compounds that conjugate molecules containing free amine groups with molecules that contain sulfhydryl groups. SPDP (N-succinimidyl 3-(2-pyridyldithio)-propionate, also called OPSS) is one of the most popular versions of this type of crosslinker. Unfortunately, SPDP and its popular varieties (LC-SPDP and Sulfo-LC-SPDP) are hydrophobic molecules. When conjugated to biomolecules, care must be taken not to modify the target molecules too much, because this can precipitate the conjugate products.

Using SPDP-dPEG®36-NHS ester

SPDP-dPEG®36-NHS ester, product number 10867, is used like SPDP and its related hydrophobic products. However, precautions against overly modifying the target molecule are not necessary. The water-soluble dPEG® product prevents hydrophobicity-triggered precipitation of compounds to which it is conjugated. Greg Hermanson’s Bioconjugate Techniques, 3rd edition, describes SPDP and related products (Chapter 6) and describes Quanta BioDesign’s dPEG® versions of these products (Chapter 18). Each of the chapters describing these crosslinkers contains detailed protocols for using them. Quanta BioDesign highly recommends and sells this book. Click here for a review and to purchase Bioconjugate Techniques, 3rd edition.

Bulk Scale Production is Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Buy Now!

If you need to conjugate amine and sulfhydryl groups, stop using inferior hydrophobic SPDP products. Click on the “Add to Cart” button today and start using our superior, water-soluble SPDP-dPEG®36-NHS ester product. You, too, can experience “the dPEG® difference” that thousands of other satisfied customers have enjoyed.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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