Amino-dPEG®36-OH, product number 10869, also known as Amino-dPEG®36-alcohol, is a very long, monodispersed PEGylation reagent functionalized with a primary amine on one end of the molecule that reacts with carboxylic acids, aldehydes, and ketones. Reacting the amine group with carboxylic acids yields stable amides while reacting the amine group with aldehydes and ketones forms Schiff bases that are reducible to secondary amines for stability. If needed, various functional and reactive groups can modify the terminal alcohol on the opposite end of the molecule to provide the dPEG® product with additional reactivity or crosslinking capability.

PEGylation with dPEG® products

All of Quanta BioDesign’s discrete PEG (dPEG®) products are monodispersed PEG products containing a single molecular weight of PEG with a discrete chain length. Conventional PEGylation reagents are dispersed polymers that consist of a broad range of different PEG molecular weights and chain lengths. Quanta BioDesign’s dPEG® products provide superior performance to conventional PEG products because each product has a single PEG chain with a well-defined purity. Also, because dPEG® products have only one PEG chain and molecular weight to consider, conjugates made with dPEG® products are simpler to analyze that conjugates prepared with dispersed polymer PEGs.

Our dPEG® products come in a variety of architectures. Many different functional, reactive, and protective groups are available on our dPEG® products. Therefore, diverse applications are possible with our products.

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What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Amino-dPEG®36-OH has many potential uses. One frequent application for this product is the passivation of carboxylate-functionalized surfaces. The non-immunogenic terminal alcohol of the PEG chain imparts hydrophilicity to the conjugate molecule or surface. Consequently, conjugate molecules are water-soluble. Other possible uses of Amino-dPEG®36-OH include the following:

  • Passivation and modification of surfaces;
  • Development of biosensors;
  • Increasing the hydrophilicity of hydrophobic molecules;
  • Reducing non-specific, hydrophobic interactions of conjugates;
  • Decreasing a conjugate’s immunogenicity;
  • As a building block for more complex structures; and,
  • Many more.

Bulk quantities are available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in