Fmoc-N-amido-dPEG®₃₆-acid

Traditional PEG versus dPEG^®

PEGylation refers to the covalent addition of polyethylene glycol (PEG) to a compound or surface. Peptide synthesis frequently employs PEGylation to enhance the solubility of the peptide, because the amphiphilic character of PEG imparts tremendous water solubility to peptides. Moreover, peptide PEGylation prolongs the in vivo circulation of peptide conjugates by both increasing the peptide’s hydrodynamic volume and protecting the peptide from proteolysis. Additionally, PEGylation reduces or eliminates the antigenicity of the conjugated peptide.

However, traditional PEGs are non-uniform polymers (Đ > 1.00). A traditional PEG consists of multiple chain lengths with different molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.

Quanta BioDesign’s single molecular weight PEG products (known as “discrete PEG” and sold under the dPEG^® trademark) provide all of the benefits of traditional PEG without the analytical headache that comes from dispersity, that is, from the intractable mixture of molecular weights and PEG chain lengths.

Using Fmoc-N-amido-dPEG^®₃₆-acid

Fmoc-N-amido-dPEG^®₃₆-acid permits our customers to insert an extended (111 atom, 132.7 Å, dPEG^®₃₆) dPEG^® into a peptide chain using Fmoc chemistry. The product works equally well in solid-phase and solution-phase synthetic processes. The dPEG^® linker attaches to the N-terminal end of the peptide chain. Additional peptide synthesis can be carried out to extend the peptide further, creating a peptide with a flexible linker or spacer in the middle. Also, the dPEG^® spacer can be used to provide additional distance in a synthetic construct where steric hindrance is a problem. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Numerous applications have used Fmoc-N-amido-dPEG^®₃₆-acid. The reference section below lists published papers that use this product. Some of the applications for Fmoc-N-amido-dPEG^®₃₆-acid include developing flexible antibodies with non-protein hinges, developing optimized liposomes for intracellular protein delivery, and developing conjugates for SPECT imaging of cancer in vivo.

Additional Fmoc-dPEG^® Products

To help our customers discover the optimum linker length necessary for a particular product or application, Fmoc-N-amido-dPEG^®₃₆-acid, product number 10903, is part of a line of Fmoc-protected amino-dPEG^® acid products. The other products in this line are listed here. Additionally, we offer a range of Fmoc-protected amino acids activated with either N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP). We invite you to consider all of our Fmoc-protected amino-dPEG^®_x-acid and active ester products whenever you need a single molecular weight PEG for your application or product development.

Commercial Scale Production

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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