m-dPEG®₃₇-NHS ester

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SDS
Product #: 10910
m-dPEG®₃₇-NHS ester
MW:    1787.07; single compound
dPEG® Spacer is 113 atoms and 132.500 Å
CAS #:    756525-94-7

Size: 100 mg $325.00
Size: 1000 mg $1,200.00
Please call or email for bulk pricing and custom syntheses!
Products Protected under U.S. Patents # 7,888,536 & 8,637,711

References:

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.

Engineering PEGylated Antibody Fragments for Enhanced Properties and Cancer Detection. Shubham Mangla. Knowledge Bank. 2016, May 2016.

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References:

m-dPEG®₂₄-NHS ester (#10304)
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Pharmacokinetics and Tumor Disposition of PEGylated Methotrexate Conjugated Poly-L-lysine Dendrimers. Lisa M. Kaminskas, Brian D. Kelly, Victoria M. McLeod, Ben J. Boyd, Guy Y. Krippner, Elizabeth D. Williams, and Christopher J. H. Porter, Molecular Pharmaceutics, Vol. 6, No. 4, 2009, 6 (4), pp 1190-1204, May 19, 2009. DOI: 10.1021/mp900049a.

Stimulation of F1-ATPase activity by sodium dodecyl sulfate. Muhammad Delawar Hossain, Shou Furuike, Yasuhiro Onoue, Keng Adachi, Masasuke Yoshida, Kazuhiko Kinosita Jr. Biochimica et Biophysica Acta (BBA)-Bioenergetics. 2010, 1797 (4) pp 435-442. April 2010. DOI: 10.1016/j.bbabio.2009.12.018.

Capping Methotrexate a-Carboxyl Groups Enhances Systemic Exposure and Retains the Cytotoxicity of Drug Conjugated PEGylated Polylysine Dendrimers. Lisa M. Kaminskas, Brian D. Kelly, Victoria M. McLeod, Gian Sberna, Ben J. Boyd, David J. Owen, and Christopher J. H. Porter. Molecular Pharmaceutics. 2011, 8 (2) pp 338–349. December 20, 2010. DOI: 10.1021/mp1001872.

Torque Generation in F1-ATPase Devoid of the Entire Amino-Terminal Helix of the Rotor That Fills Half of the Stator Orifice. Ayako Kohori, Ryohei Chiwata, Mohammad Delawar Hossain, Shou Furuike, Katsuyuki Shiroguchi, Kengo Adachi, Masasuke Yoshida, and Kazuhiko Kinosita, Jr. Biophysical Journal. 2011, 101 (1) pp 188–195. July 6, 2011. DOI: 10.1016/j.bpj.2011.05.008.

Temperature Dependence of the Rotation and Hydrolysis Activities of F1-ATPase. Furuike, Shou; Adachi, Kengo; Sakaki, Naoyoshi; Shimo-Kon, Rieko; Itoh, Hiroyasu; Muneyuki, Eiro; Yoshida, Masasuke; Kinosita, Kazuhiko, Jr. Biophysical Journal. 2008, 95 (2) pp 761-770 July 15, 2008. DOI:10.1529/biophysj.107.123307.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Analytical Chemistry. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.

Biomolecular strategies for cell surface engineering. John Tanner Wilson. Smartech. 2008, December 5, 2008.

Characterization of the Reversed-Phase Chromatographic Behavior of PEGylated Peptides Based on the Poly(ethylene glycol) Dispersity. Eun Ji Park and Dong Hee Na. Analytical Chemistry. 2016, October 25, 2016. DOI: 10.1021/acs.analchem.6b03577.

Methotrexate-Conjugated PEGylated Dendrimers Show Differential Patterns of Deposition and Activity in Tumor-Burdened Lymph Nodes after Intravenous and Subcutaneous Administration in Rats. Lisa M. Kaminsksa, Victoria M. McLeod, David B. Ascher, Gemma M. Ryan, Seth Jones, John M. Haynes, Natalie L. Trevaskis, Linda J. Chan, Erica K. Sloan, Benjamin A. Finnin, Mark Williamson, Tony Velkov, Elizabeth D. Williams, Brian D. Kelly, David J. Owen, and Christopher J.H. Porter. Molecular Pharmeceutics. 2015, 12 (2) pp 432-443. Decmber 8, 2014. DOI: 10.1021/mp500531e.

Large-scale Biophysical Evaluation of Protein PEGylation Effects: In Vitro Properties of 61 Protein Entities. Erik Vernet, Gina Popa, Irina Pozdnyakova, Jakob E. Rasmussen, Holger Grohganz, Lise Giehm, Malene H. Jensen, Huabing Wang, Bitten Plesner, Hanne M. Nielsen, Knud J. Jensen, Jens Berthelsen, Michael Sundstrom, and Marco van de Weert. Molecular Pharmaceutics. 2016, April 4, 2016. DOI: 10.1021/acs.molpharmaceut.6b00049.

Optimized polyethylenimine (PEI)-based nanoparticles for siRNA delivery, analyzed in vitro and in an ex vivo tumor tissue slice culture model. Alexander Ewe, Sabrina Hobel, Claudia Heine, Lea Merz, Sonja Kallendrusch, Ingo Bechmann, Felicitas Merz, Heike Franke, Achim Aigner. Drug Delivery and Translational Research. 2016, pp 1-11. June 22, 2016. DOI: 10.1007/s13346-016-0306-y.

Application of Fuzzy Logic Algorithm to Single-Molecule Force Spectroscopy of the Streptavidin-Biotin System. Hiroyuki Tahara, Takashi Nyu, Evan Angelo Quimada Mondarte, Tatsuhiro Maekawa, and Tomohiro Hayashi. Advances in Materials Physics and Chemistry. 2018, 8, pp 217-226. May 29, 2018. DOI: 10.4236/ampc.2018.85014.
m-dPEG®₂-NHS ester (#10327)
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Short polyethylene glycol chains densely bound to soft nanotube channels for inhibition of protein aggregation. N. Kameta, T. Matsuzawa, K. Yaoi, and M. Masuda. RSC Advances. 2016, 6 (43) pp 36744-36750. April 7, 2016. DOI: 10.1039/C6RA06793J.

Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy, Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. JACS (J. Am. Chem. Soc.). 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.
m-dPEG®₈-NHS ester (#10260)
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Short polyethylene glycol chains densely bound to soft nanotube channels for inhibition of protein aggregation. N. Kameta, T. Matsuzawa, K. Yaoi, and M. Masuda. RSC Advances. 2016, 6 (43) pp 36744-36750. April 7, 2016. DOI: 10.1039/C6RA06793J.

Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates,Gary B Braun, Alessia Pallaoro, Guohui Wi, Dimitris Missirlis, Joseph A. Zasadzinski, Matthew Tirrell, and Norbert O. Reich. ACS Nano. 2009, 3 (7), pp 2007–2015. June 15, 2009. DOI:10.1021/nn900469q.

Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy, Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. JACS. 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.

Potent D-peptide inhibitors of HIV-1 entry, Brett D. Welch, Andrew P. VanDemark, Annie Heroux, Christopher P. Hill, and Michael S. Kay. PNAS. 2007, 43 (104), pp 16828-16833. October 23, 2007. DOI: 10.1073/pnas.0708109104.

Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol. Boris N. Novikov, Janet K. Grimsley, Rory J. Kern, James R. Wild, Melinda E. Wales. Elsevier. 2010, 3 (146) pp 318-325. September 15, 2010. DOI: 10.1016/j.jconrel.2010.06.003.

Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimersw. Analette I. Lopez, Rose Y. Reins, Alison M. McDermott, Barbara W. Trautner and Chengzhi Cai. Molecular BioSystems. 2009, 10 (5), pp 1148-1156. May 28, 2009. DOI: 10.1039/b904746h.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.

Development of Polyethylene Glycol-Conjugated Alendronate, a Novel Nitrogen-Containing Bisphosphonate Derivative: Evaluation of Absorption, Safety, and Effects After Intrapulmonary Administration in Rats. HIDEMASA KATSUMI, MIKI TAKASHIMA, JUN-ICHI SANO, KAZUSHI NISHIYAMA, NORIKO KITAMURA, TOSHIYASU SAKANE, TORU HIBI, AKIRA YAMAMOTO. Journal of Pharmaceutical Sciences. 2011, 100 (9) pp 3783-3792. May 12, 2011. DOI: 10.1002/jps.22620.

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Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates,Gary B Braun, Alessia Pallaoro, Guohui Wi, Dimitris Missirlis, Joseph A. Zasadzinski, Matthew Tirrell, and Norbert O. Reich. ACS Nano. 2009, 3 (7), pp 2007–2015. June 15, 2009. DOI:10.1021/nn900469q.

Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy, Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. JACS. 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.

Potent D-peptide inhibitors of HIV-1 entry, Brett D. Welch, Andrew P. VanDemark, Annie Heroux, Christopher P. Hill, and Michael S. Kay. PNAS. 2007, 43 (104), pp 16828-16833. October 23, 2007. DOI: 10.1073/pnas.0708109104.

Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol. Boris N. Novikov, Janet K. Grimsley, Rory J. Kern, James R. Wild, Melinda E. Wales. Elsevier. 2010, 3 (146) pp 318-325. September 15, 2010. DOI: 10.1016/j.jconrel.2010.06.003.

Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimersw. Analette I. Lopez, Rose Y. Reins, Alison M. McDermott, Barbara W. Trautner and Chengzhi Cai. Molecular BioSystems. 2009, 10 (5), pp 1148-1156. May 28, 2009. DOI: 10.1039/b904746h.

Silica-Shelled Single Quantum Dot Micelles as Imaging Probes with Dual or Multimodality. Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki, Hideki Ohba, Yusuke Imai, and Iwao Kanno. Anal. Chem. 2006, 78 (16) pp 5925–5932. July 14, 2006. DOI: 10.1021/ac060412b.

Development of Polyethylene Glycol-Conjugated Alendronate, a Novel Nitrogen-Containing Bisphosphonate Derivative: Evaluation of Absorption, Safety, and Effects After Intrapulmonary Administration in Rats. HIDEMASA KATSUMI, MIKI TAKASHIMA, JUN-ICHI SANO, KAZUSHI NISHIYAMA, NORIKO KITAMURA, TOSHIYASU SAKANE, TORU HIBI, AKIRA YAMAMOTO. Journal of Pharmaceutical Sciences. 2011, 100 (9) pp 3783-3792. May 12, 2011. DOI: 10.1002/jps.22620.

Novel Comb-Shaped PEGModification Enhances the Osteoclastic Inhibitory Effect and Bone Delivery of Osteoprotegerin After Intravenous Administration in Ovariectomized Rats. Yoshihiro Miyaji, Yuji Kasuya, Yoshitake Furuta, Atsushi Kurihara, Masayuki Takahashi, Ken-ichi Ogawara, Takashi Izumi & Osamu Okazaki & Kazutaka Higaki. Pharmaceutical Research. 2012, 29 (11) pp 3143-3155. June 23, 2012. DOI 10.1007/s11095-012-0807-4.
m-dPEG®₁₂-NHS ester (#10262)
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

The impact of molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly L-Lysine Dendrimers. Lisa M. Kaminskas, Ben J. Boyd, Peter Karellas, Guy Y. Krippner, Romina Lessene, Brian Kelly, and Christopher J. H. Porter. Molecular Pharmaceutics. 2008, 5 (3), pp 449–463. April 5, 2008. DOI: 10.1021/mp7001208.

Pharmacokinetics and Tumor Disposition of PEGylated Methotrexate Conjugated Poly-L-lysine Dendrimers. Lisa M. Kaminskas, Brian D. Kelly, Victoria M. McLeod, Ben J. Boyd, Guy Y. Krippner, Elizabeth D. Williams, and Christopher J. H. Porter, Molecular Pharmaceutics, Vol. 6, No. 4, 2009, 6 (4), pp 1190-1204, May 19, 2009. DOI: 10.1021/mp900049a.

Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy. Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. Journal of the American Chemical Society. 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.

Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol. Boris N. Novikov, Janet K. Grimsley, Rory J. Kern, James R. Wild, Melinda E. Wales. Journal of Controlled Release. 2010, 146 (3) pp 318-325. September 15, 2010. DOI: 10.1016/j.jconrel.2010.06.003.

Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimers. Analette I. Lopez, Rose Y. Reins, Alison M. McDermott, Barbara W. Trautner and Chengzhi Cai. Molecular BioSystems. 2009, 10 (5) pp 1148–1156. May 26, 2009. DOI: 10.1039/b904746h.

Stability, Antimicrobial Activity, and Cytotoxicity of Poly(amidoamine) Dendrimers on Titanium Substrates. Lin Wang, Uriel J. Erasquin, Meirong Zhao, Li Ren, Martin Yi Zhang, Gary J. Cheng, Yingjun Wang, and Chengzhi Cai. ACS Applied Materials & Interfaces. 2011, 3 (8), pp 2885-2894. July 20, 2011. DOI: 10.1021/am2004398.

Prevention of benzyl alcohol-induced aggregation of chymotrypsinogen by PEGylation. José A. Rodríguez-Martínez, Izarys Rivera-Rivera and Kai Griebenow. Journal of Pharmacy and Pharmacology. 2011, 63 (6), pp 800–805. January 6, 2011. DOI: 10.1111/j.2042-7158.2011.01288.

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Antibacterial Activities of Poly (amidoamine) Dendrimers Terminated with Amino and Poly(ethylene glycol) Groups. Michelle K. Calabretta, Amit Kumar, Alison M. McDermott, and Chengzhi Cai. Biomacromolecules. 2007, 8 (6) pp 1807-1811. May 19, 2007. DOI: 10.1021/bm0701088.

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Multifunctional Separation Mechanism on Poly(oxyethylene) Stationary Phases in Capillary Liquid Chromatography. Toyohide Takeuchi and Lee Wah Lim. Analytical Sciences. 2010, 26 (9) pp 937-941. September 10, 2010. DOI: 10.2116/analsci.26.937.

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m-dPEG®₄-NHS ester (#10211)
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

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The impact of molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly L-Lysine Dendrimers. Lisa M. Kaminskas, Ben J. Boyd, Peter Karellas, Guy Y. Krippner, Romina Lessene, Brian Kelly, and Christopher J. H. Porter. Mol. Pharmaceutics. 2008, 5 (3), pp 449–463. April 5, 2008. DOI: 10.1021/mp7001208.

Hairpin Structure of a Biarsenical- Tetracysteine Motif Determined by NMR Spectroscopy. Fatemeh Madani, Jesper Lind, Peter Damberg, Stephen R. Adams, Roger Y. Tsien, and Astrid O. Graslund. Journal of the American Chemical Society. 2009, 131 (13), pp 4613–4615. March 12, 2009. DOI: 10.1021/ja809315x.

Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol. Boris N. Novikov, Janet K. Grimsley, Rory J. Kern, James R. Wild, Melinda E. Wales. Journal of Controlled Release. 2010, 146 (3) pp 318-325. September 15, 2010. DOI: 10.1016/j.jconrel.2010.06.003.

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Robust Sensing Films for Pathogen Detection and Medical Diagnostics. Aaron S. Anderson ; Andrew M. Dattelbaum ; Harshini Mukundan ;Dominique N. Price ; W. Kevin Grace ; Basil I. Swanson. Frontiers in Pathogen Detection: From Nanosensors to Systems., 2009, Proc. Of SPIE 7167. 71670q-1 February 18, 2009. 10.1117/12.809383.

Biomolecular strategies for cell surface engineering. John Tanner Wilson. Smartech. 2008, December 5, 2008.

A study of polyethylene glycol backfilling for enhancing target recognition using QCM-D and DPI. Yanqiu Du, Jing Jin, and Wei Jiang. Journal of Materials Chemistry B. 2018, 6, pp 6217-6224. September 21, 2018. DOI: 10.1039/c8tb01526k.

Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis. Atanas V. Koulov, Paul LaPointe, Bingwen Lu, Abbas Razvi, Judith Coppinger,_ Meng-Qiu Dong, Jeanne Matteson, Rob Laister, Cheryl Arrowsmith, John R. Yates III, and William E. Balch. Molecular Biology of the Cell. 2010, 21 pp 871–884. March 15, 2010. DOI: 10.1091/mbc.E09–12–1017.

Bacteriophage T4 Nanoparticles as Materials in Sensor Applications: Variables That Influence Their Organization and Assembly on Surfaces. Marie J. Archer and Jinny L. Liu. Sensors. 2009, 9 (8) pp 6298-6311. August 12, 2009. DOI: 10.3390/s90806298

Surface Modification on Acoustic Wave Biosensors for Enhanced Specificity. Onursal Onen, Asad A. Ahmad, Rasim Guldiken and Nathan D. Gallant. Sensors. 2012, 12 pp 12317-12328. September 10, 2012. DOI: 10.3390/s120912317.

Surface Functionalization and Analysis Thereof for an Ovarian Cancer Diagnostic Biosensor. Asad Ali Ahmad. USF Scholor Commons. 2011, 1 (1) pp 297-416. June 21, 2011. DOI: scholarcommons.usf.edu/etd/2977.

Production of microporous aluminum oxide electrodes as supports for tethered lipid bilayers of large surface area. Ophélie Fliniaux, Céline Elie-Caille, Jacques Pantigny, Christian Bourdillon. Electrochemistry Communications. 2005, 7(7) pp 697-702. April 19, 2005. DOI: 10.1016/j.elecom.2005.04.023

Modified Epidermal Growth Factor Receptor (EGFR)-Bearing Liposomes (MRBLs) Are Sensitive to EGF in Solution. Albert Wong. PloS One.2009, 4 (10) e7391. September 14, 2009. DOI: 10.1371/journal.pone.0007391.

Short polyethylene glycol chains densely bound to soft nanotube channels for inhibition of protein aggregation. N. Kameta, T. Matsuzawa, K. Yaoi, and M. Masuda. RSC Advances. 2016, 6 (43) pp 36744-36750. April 7, 2016. DOI: 10.1039/C6RA06793J.

Transport of biomolecules to binding partners displayed on the surface of microbeads arrayed in traps in a microfluidic cell. Xiaoxiao Chen, Thomas F Leary, and Charles Maldarelli. Biomicrofluidics. 2017, 11 (1) pp 014101. January 4, 2017. DOI: 10.1063/1.4973247.

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Mafalda M.A. Pereira, Ines Mahu, Elsa Seixas, Noelia Martinez-Sanchez, Nadiya Kubasova, Roksana M. Pirzgalska, Paul Cohen, Marcelo O. Dietrich, Miguel Lopez, Goncalo J.L. Bernardes, and Ana I. Domingos. Nature Communications. 2017, 8 (14967) pp 1-10. April 3, 2017. DOI: 10.1038/ncomms14967.