Fmoc-N-amido-dPEG®12-NHS ester, product number 10996, is one of Quanta BioDesign’s peptide synthesis products. This product is pre-activated with an N-hydroxysuccinimide (NHS) ester for conjugation to free amines. The 40-atoms-long, 46.5 Å, dPEG®12 spacer allows the introduction of a medium-length, hydrophilic spacer into, for example, a peptide chain.
PEGylation with Quanta BioDesign’s dPEG® Products
PEGylation is the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs. Peptide synthesis frequently employs PEGylation to enhance a peptide’s water solubility. Moreover, peptide PEGylation prolongs the in vivo circulation of peptide conjugates by both increasing the peptide’s hydrodynamic volume and protecting the peptide from proteolysis. Additionally, PEGylation reduces or eliminates the antigenicity of the conjugated peptide.
However, traditional PEGs are dispersed polymers (Đ > 1.00) consisting of multiple chain lengths with different molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.
Quanta BioDesign’s single molecular weight PEG products (known as “discrete PEG” and sold under the dPEG® trademark) provide all of the benefits of traditional, dispersed PEG without the analytical headache that comes from having an intractable mixture of conjugates, each with different PEG chain lengths.
Fmoc-N-amido-dPEG®12-NHS ester permits our customers to insert a medium-length (40 atoms) dPEG® into a peptide chain using standard Fmoc chemistry. The product works equally well in solid-phase and solution-phase synthetic processes. The dPEG® can be inserted at either end of the peptide chain or in the middle of two chains to provide a flexible spacer between distinct functional peptides.
Additionally, the dPEG® spacer can be used to extend the distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvents. The Fmoc protecting group removes easily with a solution of piperidine in N, N-dimethylformamide (DMF).
Fmoc-N-amido-dPEG®12-NHS ester is One Member in a Family of Products
To help our customers discover the optimum linker length necessary for a particular product or application, Fmoc-N-amido-dPEG®12-NHS ester, product number 10996, is part of a line of Fmoc-protected amino-dPEG® active ester products. We offer Fmoc-protected amino-dPEG® acids activated with either N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP). We also provide Fmoc-protected amino-dPEG® acids without acylating agent functionalization.
We invite you to consider our entire line of Fmoc-protected amino-dPEG®x-acid and active ester products whenever you need a single molecular weight PEG for your product.
Bulk Quantities Are Available
If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.
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