Specs:

 SDS

Molecular Weight: 811.82; single compound

CAS: N/A

Purity: > 98%

Spacers: dPEG® Spacer 28 atoms and 32.2 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Additional Search Phrases:

PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, peptide modification, Fmoc, 9-fluorenylmethoxycarbonyl, peptide chemistry, tetrafluorophenyl ester, tetrafluorophenol, active ester, amine reactive, TFP ester, Fmoc-N-amido-PEG8-TFP ester, Fmoc-PEG8-TFP ester, Fmoc-PEG-TFP ester



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Fmoc-N-amido-dPEG®₈-TFP ester

$175.00 – $675.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 11005 Categories: , , ,

TFP_Esters_Art2

Fmoc-N-amido-dPEG®8-TFP ester, product number 11005, is an amino-dPEG®-acid. A Fluorenylmethyloxycarbonyl (Fmoc) group protects the N-terminus of the product. A 2,3,5,6-tetrafluorophenyl (TFP) ester functionalizes the C-terminus for efficient conjugation to a peptide chain. Fmoc-N-amido-dPEG®8-TFP ester is designed to facilitate the introduction of a medium-length, hydrophilic spacer into a peptide chain. However, it can find extensive use in other applications.

PEGylation with dPEG® Products

PEGylation refers to the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs.

Because PEG is amphiphilic, peptide synthesis often employs PEGylation to enhance the water solubility of hydrophobic peptides. Moreover, peptide PEGylation (1) prolongs the in vivo circulation of conjugates by increasing the conjugate’s hydrodynamic volume, (2) protects the peptide from proteolysis, and (3) reduces or eliminates the antigenicity of the conjugated peptide.

However, traditional PEGs are dispersed polymers (Đ > 1.00). A traditional PEG consists of multiple chain lengths with various molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.

Quanta BioDesign’s single molecular weight PEG products (known as “discrete PEG” and sold under the dPEG® trademark) provide all of the benefits of traditional, dispersed PEG without the analytical headaches that come from having an intractable mixture of conjugates, each with different PEG chain lengths.

Learn more about “the dPEG® difference” by clicking the links below!

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Using Fmoc-N-amido-dPEG®8-TFP ester

Although we designed Fmoc-N-amido-dPEG®8-TFP ester for peptide synthesis, it is not limited to that specific use. This product permits our customers to conjugate a protected dPEG® amino acid to an amine. The product works equally well in solid-phase and solution-phase synthetic processes. The dPEG® can be inserted on the N-terminus of a growing peptide chain or in the middle of two peptides as a flexible spacer them. Also, the dPEG® chain can be used to provide distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct gains water solubility while remaining soluble in organic solvents. The Fmoc protecting group removes easily with a solution of piperidine in N, N-dimethylformamide (DMF).

Why Use TFP Esters?

TFP esters are generally superior to the more commonly used N-hydroxysuccinimidyl (NHS) esters. The 2,3,5,6-tetrafluorophenyl group is more stable to hydrolysis more reactive to amines than NHS esters. Quanta BioDesign has additional information on why TFP esters are superior to NHS esters on our website.

Find the Right Product for Your Project

To help our customers discover the optimum dPEG® for a particular product or application, Fmoc-N-amido-dPEG®8-TFP ester, product number 11005, is part of a line of Fmoc-protected amino-dPEG® active ester products. We offer Fmoc-protected amino-dPEG® acids activated with either TFP or NHS. We also provide Fmoc-protected amino-dPEG® acids without TFP or NHS ester functionalization. We invite you to consider our entire line of peptide modification and protected linker reagents whenever you need a single molecular weight PEG for your project.

Bulk Quantities Are Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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