Specs:

 SDS

Molecular Weight: 1525.60; single compound

CAS: N/A

Purity: > 98%

Spacers: dPEG® Spacer is 76 atoms and 90.0 Å

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Additional Search Phrases:

PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, Quanta, Quanta BioDesign, PEGylation reagent, Bromoacetamido-PEG24-amido-DBCO, DBCO-PEG24-Bromoacetamide, Bromoacetamido-PEG1000-DBCO, Bromoacetamido-PEG-DBCO



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Bromoacetamido-dPEG®₂₄-amido-DBCO

$240.00 – $2,100.00

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PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 11224 Categories: , Tags: ,

Bromoacetamido-dPEG®24-amido-DBCO, product number 11224, combines a thiol-reactive bromoacetyl group with dibenzylcyclooctyne (DBCO, also known as DIBAC), a reactive group for strain promoted azide alkyne cycloaddition. The two reactive groups are joined through a long, flexible, single molecular weight, discrete polyethylene glycol (dPEG®) linker.

Traditional PEG is a polymer consisting of an intractable mixture of different chain lengths and molecular weights in a Poisson distribution. However, each of Quanta BioDesign’s PEG products consists of a single molecular weight of PEG with a discrete chain length, hence the tradename dPEG®. Quanta BioDesign developed the processes for manufacturing dPEG® and has been the world leader in dPEG® research, development, and manufacturing since our founding in 1999. For more information about our technology, please click here. For answers to frequently asked questions, please click here.

The bromoacetyl group reacts chemoselectively with thiols at pH ≥ 8.0, in contrast to the maleimide group, which reacts chemoselectively with sulfhydryls within the range of pH 6.5 – 7.5. To learn more about the reaction of the bromoacetyl group with thiols, go to Bromoacetyl Reaction Chemistry. The DBCO moiety is a strained cyclooctyne ring with two fused benzyl rings on either side of the cyclooctyne ring. An aminopropionic acid unit extends from a ring nitrogen atom to provide a means of coupling the DBCO to the dPEG® linker. DBCO was designed for strain promoted azide alkyne cycloaddition (SPAAC), also known as copper free click chemistry. DBCO was developed by building on the work of Carolyn Bertozzi and colleagues who developed SPAAC for bio-orthogonal click chemistry applications. For more information on click chemistry applications, please go to Click Chemistry and dPEG®.

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

Application References:

  1. Hermanson, G. T. Chapter 6, Heterobifunctional Crosslinkers. Bioconjugate Techniques, 3rd edition. Academic Press, New York: 2013, pp. 299 – 339. See page 311 discussing the reactivity of the bromoacetyl group. Want to learn more about Greg’s book? Click here now for a review of Greg’s book and a link to purchase it.
  2. Hermanson, G. T. Chapter 17, Chemoselective Ligation; Bioorthogonal Reagents. Bioconjugate Techniques, 3rd edition. Academic Press: New York, 2013, pp 757-786, particularly pages 769-775 where click chemistry is discussed.
  3. Hermanson, G. T. Chapter 18, PEGylation and Synthetic Polymer Modification. Bioconjugate Techniques, 3rd edition. Academic Press, New York: 2013, pp 787 – 838.
  4. Schelté, Philippe; Boeckler, C.; Frisch, B.; Schuber, F. Differential Reactivity of Maleimide and Bromoacetyl Functions with Thiols: Application to the Preparation of Liposomal Diepitope Constructs. Bioconjugate Chem. 2000, 11(1), 118–123. https://doi.org/10.1021/bc990122k.
  5. Rosen, B. M.; Lligadas, G.; Hahn, C.; Percec, V. Synthesis of Dendrimers through Divergent Iterative Thio-Bromo “Click” Chemistry. Journal of Polymer Science Part A: Polymer Chemistry 2009, 47(15), 3931–3939. https://doi.org/10.1002/pola.23519.
  6. Dommerholt, J.; Rutjes, F. P. J. T.; van Delft, F. L. Strain-Promoted 1,3-Dipolar Cycloaddition of Cycloalkynes and Organic Azides. Top. Curr. Chem. (Z) 2016, 374(2), 16. https://doi.org/10.1007/s41061-016-0016-4.
  7. Patterson, D. M.; Nazarova, L. A.; Prescher, J. A. Finding the Right (Bioorthogonal) Chemistry. ACS Chem. Biol. 2014, 9(3), 592–605. https://doi.org/10.1021/cb400828a.
  8. Baskin, J. M.; Bertozzi, C. R. Bioorthogonal Click Chemistry: Covalent Labeling in Living Systems. QSAR & Combinatorial Science 2007, 26(11–12), 1211–1219. https://doi.org/10.1002/qsar.200740086.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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