Hydroxy-dPEG®₁₂-TFP ester

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Hydroxy-dPEG®12-TFP ester, product number 11345, is a hydroxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) compound that has a 2,3,5,6-tetrafluorophenyl (TFP) ester for conjugation to primary and secondary amines. TFP esters outperform traditional N-hydroxysuccinimide (NHS) esters because TFP esters are less susceptible to hydrolysis and more reactive towards primary and secondary amines than NHS esters. For more information on the superiority of TFP esters over NHS esters, please see, TFP Esters Have More Hydrolytic Stability and Greater Reactivity Than NHS Esters. Uses for this product include:

  • modification of amine-functionalized surfaces (g., silica, glass);
  • modification of proteins and peptides at accessible amine sites on the molecules; and,
  • construction of dendrimers, among many other applications.

To learn more about our dPEG® products, please click the links below:

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

If you need a larger amount of our product that our standard package sizes, please contact us and request a quote. Our commercial capabilities allow us to manufacture PN11345 in any size lot you need.

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Application References:

  1. Hermanson, G. T. Chapter 2, Functional Targets for Bioconjugation. Bioconjugate Techniques, 3rd edition. Academic Press: New York, 2013, 127-228. Bioconjugate Techniques by Greg Hermanson is considered by most bioconjugation experts to be an indispensable reference in this field. We encourage all of our customers to purchase a copy, and we make it available on our website. Are you interested? If so, please click here to read a review of the book and to purchase it.
  2. Hermanson, G. T. Chapter 3, The Reactions of Bioconjugation. Bioconjugate Techniques, 3rd edition. Academic Press: New York, 2013, 229-258.
  3. Hermanson, G. T. Chapter 8, Dendrimers and Dendrons. Bioconjugate Techniques, 3rd edition. Academic Press: New York, 2013, 351-386.
  4. Hermanson, G. T. Chapter 18, PEGylation and Synthetic Polymer Modification. Bioconjugate Techniques, 3rd edition. Academic Press: New York, 2013, 787-838.

Additional information

Weight .5 oz
Dimensions .75 × .75 × 2 in

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