Amino-dPEG®₁₂-Tris(-dPEG®₂₄-t-butyl ester)₃

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Amino-dPEG®12-Tris(dPEG®24-t-butyl ester)3, product number 11449, is a branched, four-arm, single molecular weight, discrete-length polyethylene glycol (dPEG®) product. Three of the arms of this monodispersed PEG crosslinker are of equal length and terminate with tert-butyl-ester-protected propionic acid groups. The terminus of the fourth, short arm is a primary amino group. Tris is the core of this branched molecule. This product crosslinks a carboxylic acid with three amino groups.

What is dPEG®?

The dPEG® tradename is Quanta BioDesign’s brand for monodisperse PEG products. The name “dPEG®” stands for “discrete PEG” because each dPEG® product contains only one length and molecular weight of PEG in the product. Our dPEG® products are quite different from traditional PEGylation reagents which are disperse polymers. To learn more about Quanta BioDesign’s dPEG® reagents, please click the links below.

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Architecture and Use of Amino-dPEG®12-Tris(dPEG®24-t-butyl ester)3

The end-to-end length of the crosslinker from the amine to the carbonyl carbon of the protected propionic acid is 169.1 – 170.1 Å (129 atoms long). The short arm is 40 atoms (54.0 – 55.0 Å) from the amine to the tris core. The three long branches are 113.2 – 114.2 Å (89 atoms) from the tris amide to the protected propionic acid group at the end of the dPEG® spacer.

The amino group that terminates the short arm of this product reacts with carboxyl groups to form amide bonds. Reactions with aldehydes and ketones form Schiff bases that are reducible to secondary amines under relatively mild conditions. A carbodiimide such as EDC conjugates the terminal amine directly to carboxylates. Active esters of carboxyl groups (for example, NHS ester or TFP ester) react with amines under neutral to slightly basic conditions. The terminal amine can be modified with a variety of functional or protecting groups as needed. Also, it can be conjugated directly to target biomolecules. Functionalization or protection of the terminal amine should precede modification of the terminal propionic acid groups on the three long arms of the molecule.

The three long branches terminate with tert-butyl ester protecting groups. These protecting groups are removable with trifluoroacetic acid (TFA). Deprotection exposes propionic acid groups. The propanoates can be conjugated directly to biomolecular targets. Alternatively, they can be converted to active esters (NHS or TFP, for example) for subsequent bioconjugation reactions.

Bulk Quantities are Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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