Specs:

 SDS

Molecular Weight: 4299.06; single compound;

CAS: N/A

Purity: > 95%

Spacers: dPEG® Spacer is 127 atoms and 103.0 Å, avg.

Shipping: Ambient

References: Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Site specific discrete PEGylation of 124I-labeled mCC49 Fab’ fragments improves tumor microPET/CT imaging in mice. Haiming Ding, Michelle M. Carleton, Stephen P. Povoski, Keisha Milum, Krishan Kumar, Kothandaraman Shankaran, George H. Hinkle, David Colcher, Rich Brody, Paul D. Davis, Alex Pokora, Mitchell Phelps, Edward W. Martin Jr., and Michael F. Tweedle. Bioconjugate Chemistry. 2013, 24 (11) pp 1945-1954. October 4, 2013. DOI: 10.1021/bc400375f.

Tumor uptake of pegylated diabodies: Balancing systemic clearance and vascular transport. Qing Li, Jason B. White, Norman C. Peterson, Keith W. Rickert, Christopher O. Lloyd, Kevin L. Allen, Kim Rosenthal, Xizhe Gao, Herren Wu, William F. Dall'Acqua, M. Jack Borrok, and Ping Tsui. Journal of Controlled Release. 2018, 279 pp 126-135. April 6, 2018. DOI: 10.1016/j.jconrel.2018.04.013.


Additional Search Phrases:

PEG, dPEG, discrete PEG, polyethylene glycol, PEGylation reagent, maleimide, maleimido, thiol reactive, sulfhydryl reactive, pharmacokinetic, pharmacokinetics, serum half-life, branched PEG, pharmacodynamic, pharmacodynamics, chemical modification reagent, chemical modification reagents, serum half-life modifier, carboxyl terminated, carboxylic acid terminated, carboxylic acid, carbonyl, MAL-PEG12-Tris(m-PEG24)3, MAL-NH-PEG600-Tris(mPEG1000)3, Branched mPEG-maleimide, Amino-PEG12-Tris(m-PEG24)3, H2N-PEG600-Tris(mPEG1000)3, Branched mPEG-amine



 SDS    Datasheet

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MAL-dPEG®₁₂-Tris(m-dPEG®₂₄)₃

$250.00 – $750.00

Clear
PRODUCT IS SOLD STRICTLY FOR INTERNAL LABORATORY AND RESEARCH PURPOSES ONLY AND HAS NOT BEEN REVIEWED BY THE FDA. PRODUCT IS NOT FOR RESALE AND CANNOT BE INCORPORATED INTO COMMERCIAL GOODS FOR ANY USE OR USED IN THE DEVELOPMENT OF COMMERCIAL PRODUCTS OR IN THE PERFORMANCE OF COMMERCIAL SERVICES UNLESS UNDER A SEPARATE LICENSING, SUPPLY, OR DISTRIBUTOR AGREEMENT WITH QUANTA BIODESIGN, LTD. For information pertaining to the commercial use of our products, please click here to contact us.

Email Sales@QuantaBioDesign.com for Bulk Pricing and Custom Syntheses
Product#: 11471 Categories: , Tags: , , , , , , , , , , , , , , , , , , , , ,

MAL-dPEG®12-Tris(m-dPEG®24)3, product number 11471, is a thiol-reactive, methyl-terminated, four-arm monodispersed PEG product designed to modulate biodistribution of conjugates. Tris forms the core of the molecule. Three equal-length methyl-terminated long arms plus one maleimido-terminated short arm extend from the tris core. The amphiphilic PEG imparts hydrophilicity to conjugates, reduces or eliminates the conjugates’ antigenicity, and increases the hydrodynamic volume of conjugated molecules. Applications for this product include eradicating renal clearance, maintaining in vivo circulation for more extended periods, and suppressing immune responses to conjugates.

PEGylation with dPEG® products

Quanta BioDesign sells its single molecular weight, discrete chain length PEG products under the dPEG® tradename. These monodispersed PEG products are not purified from a polymeric mixture but synthesized from high-purity starting materials. By contrast, traditional PEG products are dispersed polymers (Ð > 1). These dispersed PEGs may consist of dozens to hundreds of PEG oligomers, which can make the analysis of conjugates rather challenging.

Our dPEG® products provide all of the benefits of traditional PEG products without analytical headaches. By simplifying the analysis of conjugates, our customers save time, money, and aggravation.

Moreover, our dPEG® products consistently demonstrate superior performance to conventional PEGs. We call this “the dPEG® difference.”

The maleimido group of MAL-dPEG®12-Tris(m-dPEG®24)3 reacts specifically with sulfhydryl groups at pH < 7.5. Antibodies, including Fab’ fragments and diabodies, can be modified site-specifically in a controlled manner using this product. The conjugate thus formed can then be characterized better.

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What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Bulk quantities are available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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