MAL-[NH-dPEG®₄-Glu(TFP ester)]₃-NH-m-dPEG®₂₄



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MAL-[NH-dPEG®4-Glu(TFP ester)]3-NH-m-dPEG®24, product number 11597, is a novel, patent-pending Sidewinder™ product from Quanta BioDesign that permits attachment of hydrophobic groups on the sidearms of three glutamic acid moieties. Short hydrophilic spacers separate the three glutamates, and a long hydrophilic dPEG® unit terminates the construct. A sulfhydryl-reactive maleimide group provides an attachment point for the construct to another molecule, such as a protein or peptide. Tetrafluorophenyl esters functionalize the three glutamate units along the Sidewinder™ backbone.

What is dPEG®?

The dPEG® tradename describes Quanta BioDesign’s patented brand of monodispersed PEGylation reagents. Quanta BioDesign’s dPEG® products are high-purity, single molecular weight PEG products with discrete chain lengths. (The “d” in the dPEG® name stands for “discrete.”) Our products have no dispersity (Ð = 1), unlike traditional PEG products, which are dispersed polymers.

Furthermore, we do not purify our products from a polymeric mixture. Instead, we synthesize dPEG® products from very high-purity starting materials using the traditional tools of synthetic organic chemistry. The result is a well-defined, monodisperse PEG product with high purity and superior performance to a dispersed PEG product. At Quanta BioDesign, we call this “the dPEG® difference.”

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What is dPEG®?

Frequently Asked Questions (about dPEG® products)

What is a Sidewinder™ product?

The Sidewinder™ line of products is a novel, patent-pending product line that permits attachment of a hydrophobic drug or other small molecules on the sidearm of an amino acid with dPEG® linkers on either side of the amino acid imparting hydrophilicity, increasing hydrodynamic volume, and protecting from proteolysis. This unique line of products allows users to optimize biodistribution, modulate cell trafficking and internalization, extend serum half-life, and reduce or eliminate immunogenicity.

All Sidewinder™ products consist of a functional group for attachment, a short hydrophilic spacer, an amino acid attachment point for functional groups such as small molecule drugs, and a long hydrophilic, non-immunogenic spacer that protects the functional group on the amino acid’s sidearm. One typical use for a Sidewinder™ product is creating antibody-drug conjugates (ADCs) with a high drug-antibody ratio (DAR).

Importantly, Sidewinder™ products have nearly infinite variability. The spacer length between the terminal reactive group and the amino acid can be as long or short as desired. The amino acid can be varied to include any functionality desired on the sidearm. The terminal protective dPEG® moiety varies in both length and terminal functionality. Also, Sidewinder™ arms can contain multiple amino acids with different functional groups on the sidearms, allowing for highly complex supramolecular constructs.

For more information about our Sidewinder™ products, please see Sidewinder™ dPEG® Constructs. To learn more about our dPEG® products, please click the following links:

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Bulk Quantities Are Available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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To get started with your purchase of MAL-[NH-dPEG®4-Glu(TFP ester)]3-NH-m-dPEG®24, product number 11597, please click the “Add to Cart” button now.

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