Hydroxy-dPEG®₆-t-butyl ester

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Hydroxy-dPEG®6-t-butyl ester, product number 10717, is a versatile building block based upon a monodispersed polyethylene glycol (PEG) chain. The single molecular weight, discrete-length PEG (dPEG®) chain is 22 atoms (25.1 Å) long. A primary alcohol group terminates one end of the molecule. The opposite end is a propionic acid group protected as the tert-butyl ester. The terminal hydroxy group can be functionalized with various reactive groups to permit direct modification of surfaces, small molecules, or biomolecules. The tert-butyl ester deprotects with trifluoroacetic acid (TFA), exposing the terminal propionic acid, which can then be activated as the NHS or TFP ester or directly coupled to an amine using a suitable carbodiimide.

PEGylation with dPEG® products

Quanta BioDesign’s dPEG® products are uniform (that is, monodispersed) polyethylene glycol (PEG) products. Unlike traditional PEGylation reagents, Quanta BioDesign’s dPEG® products have no dispersity. We synthesize our dPEG® reagents from highly pure building blocks. Our single molecular weight, discrete length PEG (dPEG®) products simplify the analysis of conjugates compared to dispersed PEG products because our dPEG® products contain only one PEG chain. A simplified analysis saves our customers time and money. At Quanta BioDesign, we call the distinction between traditional PEG and dPEG® products, “the dPEG® difference.”

Learn more about our dPEG® products!

What is dPEG®?

Frequently Asked Questions (about dPEG® products)

Using Hydroxy-dPEG®6t-butyl ester

Because we cannot anticipate every product type that our customers might need, we designed Hydroxy-dPEG®6t-butyl ester for customers who need a dPEG® product that we do not have. The terminal hydroxy group can be modified, as shown in the application schematic. Upon the completion of modifications to the terminal hydroxy group, the tert-butyl ester can be removed using TFA, thus exposing the terminal propionic acid. EDC and other carbodiimides conjugate amines directly to the propionic acid group forming amide bonds. Alternatively, functionalization of the propionic acid group as an active ester using N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) permits amide bond formation at a later time.

Bulk Quantities of Hydroxy-dPEG®6-t-butyl ester are available

If you need bulk product in a larger package size than our standard sizes, please contact us for a quote. Our commercial capabilities permit us to manufacture this product at any scale that you need.

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Discover the dPEG® difference! Save time and money by switching from dispersed PEGylation reagents to dPEG® products. Click the “Add to Cart” button now to purchase Hydroxy-dPEG®6t-butyl ester.

Additional information

Weight.5 oz
Dimensions.75 × .75 × 2 in