MAL-dPEG®x-NHS ester

MAL-dPEG®x-NHS ester
  • MAL-dPEG®₂-NHS ester
    MW:    425.39; single compound
    dPEG® Spacer is 16 atoms and 17.934 Å
    CAS #:    955094-26-5
  • MAL-dPEG®₄-NHS ester
    MW:    513.50; single compound
    dPEG® Spacer is 22 atoms and 22.809 Å
    CAS #:    756525-99-2
  • MAL-dPEG®₆-NHS ester
    MW:    601.60; single compound
    dPEG® Spacer is 28 atoms and 32.103 Å
    CAS #:    1137109-21-7
  • MAL-dPEG®₈-NHS ester
    MW:    689.71; single compound
    dPEG® Spacer is 34 atoms and 37.036 Å
    CAS #:    756525-93-6
  • MAL-dPEG®₁₂-NHS ester
    MW:    865.92; single compound
    dPEG® Spacer is 46 atoms and 51.064 Å
    CAS #:    756525-92-5
  • MAL-dPEG®₂₄-NHS ester
    MW:    1394.55; single compound
    dPEG® Spacer is 82 atoms and 93.505 Å
    CAS #:    756525-92-5

References:

MAL-dPEG®₂-NHS ester (#10266)
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, as well as his specific discussion with protocols of our MAL-dPEG®x-NHS esters on pp. 718-722.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Cell selective targeting of a simian virus 40 virus-like particle conjugated to epidermal growth factor. Yuichi Kitai, Hajime Fukuda, Teruya Enomoto, Yuki Asakawa, Takahiro Suzuki, Satoshi Inouye, Hiroshi Handa. Journal of Biotechnology. 2011, 155 (2) pp 251-256. Sept 10, 2011. DOI: 10.1016/j.jbiotec.2011.06.030.

Conjugation of Peptides to the Passivation Shell of Gold Nanoparticles for Targeting of Cell-Surface Receptors. Lisa Maus, Oliver Dick, Hilmar Bading, Joachim P. Spatz, and Roberto Fiammengo. ACS Nano. 2010, 4 (11), pp 6617–6628. October 12, 2010. DOI: 10.1021/nn101867w.

Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of celleselectin interaction kinetics. Hao Cheng, Marta Byrska-Bishop, Cathy T. Zhang, Christian J. Kastrup, Nathaniel S. Hwang, Albert K. Tai, Won Woo Lee, Xiaoyang Xu, Matthias Nahrendorf , Robert Langer, Daniel G. Anderson. Biomaterials. 2012, 33 (20), pp 5004-5012. July 2012. DOI: 10.1016/j.biomaterials.2012.03.065.

Sensitive detection of small molecule–protein interactions on a metal-insulator-metal label-free biosensing platform. Amir Syahir, Kotaro Kajikawa and Hisakazu Mihara. Europe PubMed Central. 2012, 7 (8) pp 1867-1874. May 25, 2012. DOI: 10.1002/asia.201200138.

Aptamer-Containing Surfaces for Selective Capture of CD4 Expressing Cells. Qing Zhou, Ying Liu, Dong-Sik Shin, Jaime Silangcruz, Nazgul Tuleuova, and Alexander Revzin. Langmuir. 2012, 28 (34) pp 12544−12549. August 1, 2012. DOI: 10.1021/la2050338.

NIR light controlled photorelease of siRNA and its targeted intracellular delivery based on upconversion Nanoparticles. Yanmei Yang, Fang Liu, Xiaogang Liu and Bengang Xing. Nanoscale. 2013, 5 (1) pp 231-238. Oct 30, 2012. DOI: 10.1039/C2NR32835F.

Attachment of hydrogel microstructures and proteins to glass via thiol-terminated silanes. Jeong Hyun Seo, Dong-Sik Shin, Priam Mukundan, Alexander Revzin. Colloids and Surfaces B: Biointerfaces. 2012, 98 pp 1–6. October 1, 2012. DOI: org/10.1016/j.colsurfb.2012.03.025.

A sandwich-type DNA array platform for detection of GM targets in multiplex assay. Sena Cansız, Can Ozen, Ceren Bayrac, A. Tahir Bayrac, Fatma Gul, Murat Kavruk, Remziye Yılmaz, Fusun Eyidogan, Huseyin, Avni Oktem. European Food Research and Technology. 2012, 235 (3) pp 429-437. July 6, 2012. DOI: 10.1007/s00217-012-1767-y.

Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins. David J Marshall, Scott S Harried, John L Murphy, Chad A Hall, Mohammed S Shekhani, Christophe Pain, Conner A Lyons, Antonella Chillemi, Fabio Malavsi, Homer L Pearce, Jon S Thorson, and James R Prudent. MT Open. 2016. July 19, 2016. DOI: 10.1038/mt.2016.119.

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A virus-like particle vaccine platform elicits heightened and hastened local lung mucosal antibody production after a single dose. Laura E. Richert, Amy E. Servidb, Ann L. Harmsen, Agnieszka Rynda-Apple, Soo Han, James A. Wiley, Trevor Douglas, Allen G. Harmsen. Vaccine. 2012, 30 (24) pp 3653-3665. May 21, 2012. DOI: 10.1016/j.vaccine.2012.03.035.

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A neutralized non-charged polyethylenimine-based system for efficient delivery of siRNA into heart without toxicity. Fang Wang, Lu Gao, Liu-Yi Meng, Jing-Ming Xie, Jing-Wei Xiong, and Ying Luo. ACS Applied Materials and Interfaces. 2016, pp 1-43. November 17, 2016. DOI: 10.1021/acsami.6b13295.

Drug-free albumin-triggered sensitization of cancer cells to anticancer drugs. LianLi, Jiyuan Yang, Sirima Soodvilaia, Jiawei Wang, Praneet Opanasopit, Jindřich Kopeček. Journal of Controlled Release. 2018, 293 (2019) pp 84-93. November 19, 2018. https://doi.org/10.1016/j.jconrel.2018.11.015.
MAL-dPEG®₄-NHS ester (#10214)
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, as well as his specific discussion with protocols of our MAL-dPEG®x-NHS esters on pp. 718-722.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

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Synthesis and Evaluation of Hydrophilic Linkers for Antibody-Maytansinoid Conjugates. Robert Y. Zhao, Sharon D. Wilhelm, Charlene Audette, Gregory Jones, Barbara A. Leece, Alexandru C. Lazar, Victor S. Goldmacher, Rajeeva Singh, Yelena Kovtun, Wayne C. Widdison, John M. Lambert, and Ravi V. J. Chari. J. Medicinal Chemistry. 2011, 54 (10), pp 3606–3623. April 25, 2011. DOI: 10.1021/jm2002958.

Self-Protecting Bactericidal Titanium Alloy Surface Formed by Covalent Bonding of Daptomycin Bisphosphonates. Chang-Po Chen and Eric Wickstrom. Bioconjugate Chemistry. 2010, 21 (11), pp 1978–1986. Nov. 17, 2010. DOI: 10.1021/bc100136e.

Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Jiang Xia, Elin Bergseng, Burkhard Fleckenstein, Matthew Siegel, Chu-Young Kim, Chaitan Khosla and Ludvig M. Sollid. Bioorganic & Medicinal Chemistry. 2007, 20 (15), pp 6565–6573. July 25, 2007. DOI: 10.1016/j.bmc.2007.07.001.

Immobilizing Reporters for Molecular Imaging of the Extracellular Microenvironment in Living Animals. Zuyong Xia, Yun Xing, Jongho Jeon, Young-Pil Kim, Jessica Gall, Anca Dragulescu-Andrasi, Sanjiv S. Gambhir, and Jianghong Rao. ACS Chemical Biology. 2011, 6 (10), pp 1117–1126. August 10, 2011. DOI: 10.1021/cb200135e.

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Cell-Penetrating Peptide-Functionalized Quantum Dots for Intracellular Delivery. Betty R. Liu, Yue-Wern Huang, Huey-Jenn Chiang, and Han-Jung Lee, JNN, 2010. 10 (12) pp. 7897-7905. December 2010. DOI: 10.1166/jnn.2010.3012.

Therapy of Murine Pulmonary Aspergillosis with Antibody-Alliinase

Conjugates and Alliin. Elena Appel, Alexandra Vallon-Eberhard, Aharon Rabinkov, Ori Brenner, Irina Shin, Keren Sasson, Yona Shadkchan, Nir Osherov, Steffen Jung, and David Mirelman. AAC. 2010. 54 (2) pp 898–906. February 1,2010. DOI: 10.1128/AAC.01267-09.

Maize rayado fino virus virus-like particles expressed in tobacco plants: A new platform for cysteine selective bioconjugation peptide display. Angela Natilla, Rosemarie W. Hammond. Journal of Virological Methods. 2011, 178 (1-2) pp 209-215. September 22, 2011. DOI: 10.1016/j.jviromet.2011.09.013.

Transfection efficiency of depolymerized chitosan and epidermal growth factor conjugated to chitosan–DNA polyplexes. Sasamon Supaprutsakul, Wilaiwan Chotigeat, Supreya Wanichpakorn, Ureporn Kedjarune-Leggat. Journal of Materials Science- Materials in Medicine. 2010, 21 (5) pp 1553-1561. May 1, 2010. DOI: 10.1007/s10856-010-3993-9.

Development and characterization of chitosan-PEG-TAT nanoparticles for the intracellular delivery of siRNA. International Journal of Nanomedicine. 2013, 8 pp 2041–2052. May 20, 2013. DOI: 10.2147/IJN.S43683.

Surface Coating Directed Cellular Delivery Of TAT-Functionalized Quantum Dots. Yifeng Wei, Nikhil R. Jana, Shawn J. Tan, and Jackie Y. Ying. Bioconjugate Chem. 2009, 20 (9) pp1752-1758. August 14, 2009. DOI: 10.1021/bc8003777.

Targeted nanogels: a versatile platform for drug delivery to tumors. Eric A. Murphy, Bharat K. Majeti, Rajesh Mukthavaram, Lisette M. Acevedo,Leo A. Barnes, and David A. Cheresh. Molecular Cancer Therapeutics. 2011, 10 (6) pp 972-982. April 25, 2011. DOI: 10.1158/1535-7163.MCT-10-0729.

To Target or Not to Target: Active vs. Passive Tumor Homing of Filamentous Nanoparticles Based on Potato virus X. Sourabh Shukla, Nicholas A. DiFranco, Amy M. Wen and Nicole F. Steinmetz. Cellular and Molecular Bioengineering. 2015, pp 1-24. April 8, 2015. DOI: 10.1007/s12195-015-0388-5.

Biocompatible and biodegradable fibrinogen microshperes for tumor-targeted doxorubicin delivery. Jae Yeon Joo, GilYong Park, and Seong Soo A An. International Journal of Nanomedicine. 2015, 10 pp 101-111. September 1, 2015. DOI: 10.2147/IJN.S88381.

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Serum albumin ‘camouflage’ of plant virus based nanoparticles prevents their antibody recognition and enhances pharmacokinetics. Andrzej S. Pitek, Slater A. Jameson, Frank A. Veliz, Sourabh Shukla, and Nicole F. Steinmetz. Biomaterials. 2016, 89 pp 89-97, February 23, 2016. DOI: 10.1016/j.biomaterials.2016.02.032.

Biogenic and Synthetic Peptides with Oppositely Charged Amino Acids as Binding Sites for Mineralization. Marie-Louise Lemloh, Klara Altintoprak, Christina Wege, Ingrid M Weiss, and Dirk Rothenstein. Materials. 2017, 10 (119) pp 1-15. January 28, 2017. DOI: 10.3390/ma10020119.

Affinity-Based Assembly of Peptides on Plasmonic Nanoparticles Delivered Intracellularly with Light Activated Control. Demosthenes P Morales, William Wonderly, Xiao Huang, Meghan McAdams, Amanda Chron, and Norbert O Reich. Bioconjugate Chemistry. 2017, pp 1-6. May 19, 2017. DOI: 10.1021/acs.bioconjchem.7b00276.

Elongated plant virus-based nanoparticles for enhanced delivery of thrombolytic therapies. Andrzej Stanislaw Pitek, Yunmei Wang, Sahil Gulati, Huiyun Gao, Phoebe L Stewart, Daniel I. Simon, and Nicole F Steinmetz. Molecular Pharmaceutics. 2017, pp 1-9. September 7, 2017. DOI: 10.1021/acs.molpharmaceut.7b00559.

Magnetic Semiconductor Gd-Doping CuS Nanoparticles as Activatable Nanoprobes for Bimodal Imaging and Targeted Photothermal Therapy of Gastric Tumors. Hua Sh , Yidan Sun, Runqi Yan, Shunli Liu, Li Zhu, Song Liu, Yuzhang Feng, Peng Wang, Jian He, Zhengyang Zhou, and Deju Ye. Nano Letters. 2019. January 28, 2019. DOI: 10.1021/acs.nanolett.8b04179

A Viral Nanoparticle Cancer Vaccine Delays Tumor Progression and Prolongs Survival in a HER2+ Tumor Mouse Model. Sourabh Shukla, Michal Jandzinski, Chao Wang, Xingjian Gong, Kristen Weber Bonk, Ruth A. Keri, Nicole F. Steinmetz. 2019. January 29, 2019. https://doi.org/10.1002/adtp.201800139.

Let There Be Light: Targeted Photodynamic Therapy Using High Aspect Ratio Plant Viral Nanoparticles. Paul L. Chariou, Lu Wang, Cian Desai, Jooneon Park, Leanna K. Robbins, Horst A. von Recum, Reza A. Ghiladi, Nicole F. Steinmetz. Cancer Phototherapy. 2019. https://doi.org/10.1002/mabi.201800407

Reductively cleavable polymer-drug conjugates based on dendritic polyglycerol sulfate and monomethyl auristatin E as anticancer drugs. Nadine Rades, Katharina Achazi, Min Qiu, Chao Deng, Rainer Haag, Zhiyuan Zhong, Kai Licha. Journal of Controlled Release. 2019. 300 (2019) pp 13-21. February 19, 2019. doi.org/10.1016/j.jconrel.2019.01.035

Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery. Erin Morgan, John T. Gamble, Martin C. Pearce, Daniel J. Elson, Robert L. Tanguay, Siva Kumar Kolluri, Norbert O. Reich. Apoptosis. 2019, Volume 24, Issue 5-6, pp 529-537. March 16, 2019. DOI: https://doi.org/10.1007/s10495-019-01531-1

Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging. Kritee Pant, Christin Neuber, Kristof Zarschler, Johanna Wodtke, Sebastian Meister, Rainer Haag, Jens Pietzsch, Holger Stephan. Small, 2019, 1095013. December 26, 2019. DOI: 10.1002/smll.201905013
MAL-dPEG®₆-NHS ester (#10064)
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, as well as his specific discussion with protocols of our MAL-dPEG®x-NHS esters on pp. 718-722.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Direct Cell Surface Modification with DNA for the Capture of Primary Cells and the Investion of Myotube Formation on Defined Patterns. Sonny C. Haiso, Betty J. Shaun, Hiroaki Onoe, Erik S. Douglas, Zev J. Gartner, Richard A. Mathies, Carolyn R. Bertozzi, and Matthew B. Francis. Langmuir. 2009, 25 (12), pp 6985–6991. April 29, 2009. DOI: 10.1021/la900150n.

A sandwich-type DNA array platform for detection of GM targets in multiplex assay.Sena Cansız, Can Ozen, Ceren Bayrac, A. Tahir Bayrac, Fatma Gul, Murat Kavruk, Remziye Yılmaz, Fusun Eyidogan, Huseyin, Avni Oktem. European Food Research and Technology. 2012, 235 (3) pp 429-437. July 6, 2012. DOI:10.1007/s00217-0121767y.

A virus-like particle vaccine platform elicits heightened and hastened local lung mucosal antibody production after a single dose. Laura E. Richert, Amy E. Servidb, Ann L. Harmsen, Agnieszka Rynda-Apple, Soo Han, James A. Wiley, Trevor Douglas, Allen G. Harmsen. Vaccine. 2012, 30 (24) pp 3653-3665. May 21, 2012. DOI: 10.1016/j.vaccine.2012.03.035.

New Assay for Quantification of PEGylated Proteins During in Vitro Permeability Studies.Spela Jalen, Vanja Smilovic, Katarina Fidler, Barbara Podobnik, Maja Marusic, Radovan Komel, Vladka Gaberc-Porekar and Simona Jevsevar. Acta Chimica Slovenica. 2014, 61 (3) pp 615-622. January 15, 2014.

Optimization, Production and Characterization of a CpG-Oligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen. Bob Milley, Radwan Kiwan, Gary S. Ott, Carlo Calacsan, Melissa Kachura, John D Campbell, Holger Kanzler, and Robert L. Coffman. Bioconjugate Chemistry. 2016, April 13, 2016. DOI: 10.1021/acs.bioconjchem.6b00107.

Immune Response Modulation of Conjugated Agonists with Changing Linker Length. Keun Ah Ryu, Katarzyna Slowinska, Troy Moore, and Aaron Esser-Kahn. ACS Chemical Biology. 2016, October 17, 2016. DOI: 10.1021/acschembio.6b00895.

Surface Coating of Nanoparticles Reduces Background Inflammatory Activity while Increasing Particle Uptake and Delivery. Brittany A Moser, Rachel C Steinhardt, and Aaron P Esser-Kahn. ACS Biomaterials Science and Engineering. 2016. December 1, 2016. DOI: 10.1021/acsbiomaterials.6b00473.

The Interactions of Smooth, Skeletal, and Cardiac Myosin Filaments with Actin Provide Evidence for a Novel Mixed-Kinetic Model of Actomyosin Mechanochemistry. Brizendine, Richard. Doctoral Dissertation, University of Nevada, Reno, Nevada. August 2019. http://hdl.handle.net/11714/5993.
MAL-dPEG®₈-NHS ester (#10274)
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, as well as his specific discussion with protocols of our MAL-dPEG®x-NHS esters on pp. 718-722.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Molecular Pincers: Antibody-Based Homogeneous Protein Sensors. Ewa Heyduk, Benjamin Dummit, Yie-Hwa Chang, and Tomasz Heyduk. Analytical Chemistry. 2008, 80 (13) pp 5152-5159. May 21, 2008. DOI: 10.1021/ac8004154.

Reprogramming cardiomyocyte mechanosensing by crosstalk between integrins and hyaluronic acid receptors. Anant Chopra, Victor Lin, Amanda McCollough, Sarah Atzet, Glenn D. Prestwich, Andrew S. Wechsler, Maria E. Murray, Shaina A. Oake, J. Yasha Kresh, Paul A. Janmey. Journal of Biomechanics. 2012, 45 (5), pp 824-831. October 4, 2011. DOI:10.1016/j.jbiomech.2011.11.023.

Intercellular and Extracellular Adhesion Signals Control Cardiac Myocyte Structural and Functional Remodeling: Mechanosensing Mediated by Cadherin and Haluronan rRceptors. Anant Chopra. Doctoral Dissertation, Drexel University: Philadelphia, PA, May 2012. http://hdl.handle.net/1860/3777.

Fluorescent homogeneous immunosensors for detecting pathogenic bacteria. Ewa Heyduk, Tomasz Heyduk. Analytical Biochemistry. 2010, 396 (2) pp 298–303. September 24, 2009. DOI:10.1016/j.ab.2009.09.039.

Photounbinding of Calmodulin from a Family of CaM Binding Peptides. Klaus G. Neumu ller, Kareem Elsayad, Johannes M. Reisecker, M. Neal Waxham, Katrin G. Heinze. PLoS ONE. 2010, 5 (11) pp e14050. November 18, 2010. DOI: 10.1371/journal.pone.0014050.

Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants. Yu Feng, Mattias N.E. Forsell, Barbara Flynn, William Adams, Karin Loré, Robert Seder, Richard T. Wyatt, Gunilla B. Karlsson Hedestam. Virology. 2013, 446 (1-2) pp 56-65. August 15, 2013. DOI: 10.1016/j.virol.2013.07.028.

Peptide ligands that use a novel binding site to target both TGF-B receptors. Lingyin Li, Brendan P. Orner, Tao Huang,b Andrew P. Hinck and Laura L. Kiessling. Molecular BioSystems. 2010. 6 (12) pp 2341-2576. September 3, 2010. DOI: 10.1039/c0mb00115e.

Detection Methodology Based on Target Molecule-Induced Sequence-Specific Binding to a Single-Stranded Oligonucleotide. Agnieszka Lass-Napiorkowska, Ewa Heyduk, Ling Tian, and Tomasz Heyduk. Analytical Chemistry. 2012, 84 (7), pp 3382–3389. March 7, 2012. DOI: 10.1021/ac3001034.

Imaging of Hsp70-positive tumors with cmHsp70.1 antibody-conjugated gold nanoparticles. Mathias K Gehrmann, Melanie A Kimm, Stefan Stangl, Thomas E Schmid, Peter B Noel, Ernst J Runneny, and Gabriele Multhoff. International Journal of Nanomedicine. 2015, 10, pp 5687-5700. September 8, 2015. DOI: 10.2147/IJN.S87174.

Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. Arnaud C. Tiberghien, Jean-Noel Levy, Luke A. Masterson, Neki V. Patel, Lauren R. Adams, Simon Corbett, David G. Williams, John A. Hartley, and Philip W. Howard. ACS Medicinal Chemistry Letters. 2016, 7 (11), pp 983–987. May 24, 2016. DOI: 10.1021/acsmedchemlett.6b00062.

Mapping of Molecular Structure of the Nanoscale Surface in Bio-nanoparticles. Luciana M Herda, Delyan R Hristov, Maria Cristina Lo Giudice, Ester Polo, and Kenneth A Dawson. Journal of the American Chemical Society. 2016. December 22, 2016. DOI: 10.1021/jacs.6b12297.

Enhanced Systemic Anti-Angiogenic siVEGF Delivery using PEGylated Oligo-D-Arginine. Jee Young Chung, Qurrat Ul Ain, Hyun-Lin Lee, So-Mi Kim, and Yong-Hee Kim. Molecular Pharmaceutics. 2017, pp 1-36. July 13, 2017. DOI: 10.1021/acs.molpharmaceut.7b00282.

Development of the Bioluminescent Immunoassay for the Detection of 5-Hydroxymethylcytosine in Dinoflagellate. Chun Wu, Takaaki Kurinomaru . Analytical Sciences. 2018. November 9, 2018. https://doi.org/10.2116/analsci.18P401.

Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer. Jason B. White, Ryan Fleming, Luke Masterson, Ben T. Ruddle, Haihong Zhong, Christine Fazenbaker, Patrick Strout, Kim Rosenthal, Molly Reed, Vanessa Muniz-Medina, Philip Howard, Rakesh Dixit, Herren Wu, Mary Jane Hinrichs, Changshou Gao & Nazzareno Dimasi. mAbs. 2019. March 5, 2019. DOI: 10.1080/19420862.2019.1578611
MAL-dPEG®₁₂-NHS ester (#10284)
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, as well as his specific discussion with protocols of our MAL-dPEG®x-NHS esters on pp. 718-722.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Optimal Surface Chemistry for Peptide Immobilization in On-Chip Phosporylation Analysis.Kazuki Inamori, Motoki Kyo, Kazuki Matsukawa, Yusuke Inoue, Tatsuhiko Sonoda, Kenji Tatematsu, Katsuyuki Tanizawa, Takeshi Mori, and Yoshiki Katayama. Analytical Chemistry. 2008, 80 (3), pp 643–650. January 8, 2008. DOI: 10.1021/ac701667g.

Efficient Transfection of Blood-Brain Barrier Endothelial Cells by Lipoplexes and Polyplexes in the Presence of Nuclear Targeting NLS-PEG-Acridine Conjugates. Hongwei Zhang, Anton Mitin, and Serguei V. Vinogradov. Bioconjugate Chemistry. 2009, 20 (1), pp 120–128. December 9, 2008. DOI: 10.1021/bc8003414.

Improved Biodistribution and Radioimmunoimaging with Poly(ethylene glycol)-DOTA-Conjugated Anti-CEA Diabody. Lin li, Paul J. Yazaki, Anne-Line Anderson, Desiree Crow, David Colcher, Anna M. Wu, Lawrence E. Williams, Jeffrey Y.C. Wong, Andrew Raubitschek, and John E. Shively. Bioconjugate Chemistry. 2006, 17 (1), pp 68–76. December 24, 2005. DOI: 10.1021/bc0502614.

A proof of the specificity of kanamycin-ribosomal RNA interaction with designed synthetic analogs and the antibacterial activity. Yoshio Nishimura, Hayamitsu Adachi, Motoki Kyo, Shoichi Murakami, Seiko Hattori, and Keiichi Ajito. Bioorganic & Medicinal Chemistry Letters. 2005, 15 (8), pp 2159-2162. April 15, 2005. DOI: 10.1016/j.bmcl.2005.02.043.

Recognition Imaging with a DNA Aptamer. Liyun Lin, Hongda Wang, Yan Liu, Hao Yan, and Stuart Lindsay. Biophysical Journal. 2006, 90 (11), pp 4236-4238. June 1, 2006. DOI: 10.1529/biophysj.105.079111.

Genotyping by allele-specific L-DNA-tagged PCR. Gosuke Hayashi, Masaki Hagihara, Kazuhiko Nakatani. Journal of Biotechnology. 2008, 135 (2), pp 157-160. June 1, 2008. DOI: 10.1016/j.jbiotec.2008.03.011.

Single-molecule detection of phosphorylation-induced plasticity changes during ezrin activation. Dan Liu, Ling Ge, Fengsong Wang, Hirohide Takahashi, Dongmei Wang, Zhen Guo, Shige H. Yoshimura, Tarsha Ward, Xia Ding, Kunio Takeyasu, Xuebiao Yao. FEBS Letters. 2007, 581 (18), pp 3563-3571. July 24, 2007. DOI: 10.1016/j.febslet.2007.06.071.

Development of glutathione-coupled cantilever for the single-molecule force measurement by scanning force microscopy. Shige H. Yoshimua, Hirohide Takahashi, Shotaro Otsuka, Kunio Takeyasu. FEBS Letters. 2006, 580 (16), pp 3961-3965. July 10, 2006. DOI: 10.1016/j.febslet.2006.06.032.

Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application. Shuji Yamashita, Hiromitsu Fukushima, Yasuyuki Akiyama, Yasuro Niidome, Takeshi Mori, Yoshiki Katayama, Takuro Niidome. Bioorganic & Medicinal Chemistry. 2011, 19 (7), pp 2130-2135. April 1, 2011. DOI: 10.1016/j.bmc.2011.02.042.

Interaction of Synaptotagmin with Lipid Bilayers, Analyzed by Single-Molecule Force Spectroscopy. Hirohide Takahashi, Victor Shahin, Robert M. Henderson, Kunio Takeyasu, and J. Michael Edwardson. Biophysical Journal. 2010, 99 (8), pp 2550–2558, October 20, 2010. DOI: 10.1016/j.bpj.2010.08.047.

Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Jiang Xia, Elin Bergseng, Burkhard Fleckenstein, Matthew Siegel, Chu-Young Kim, Chaitan Khosla and Ludvig M. Sollid. Bioorganic & Medicinal Chemistry. 2007, 15 (20), pp 6565-6573. October 15, 2007. DOI: 10.1016/j.bmc.2007.07.001.

Directed Intermixing in Multicomponent Self-Assembling Biomaterials. Joshua Z. Gasiorowski and Joel H. Collier. Biomacromolecules. 2011, 12 (10), pp 3549–3558. August 25, 2011. DOI: 10.1021/bm200763y.

Design of a Modular Tetrameric Scaffold for the Synthesis of Membrane-Localized D-Peptide Inhibitors of HIV-1 Entry. J. Nicholas Francis, Joseph S. Redman, Debra M. Eckert, and Michael S. Kay. Bioconjugate Chemistry. 2012, 23 (6), pp 1252-1258. May 1, 2012. DOI: 10.1021/bc300076f.

Single-molecule Structural and Functional Analyses of Nuclear Pore Complex. Otsuka, S, Takahashi, H, Yoshimura, Shige H. Micro-NanoMechatronics and Human Science. 2006. November 5, 2006. DOI:10.1109/MHS.2006.320314.

Effect of Compressive Force on Unbinding Specific Protein−Ligand Complexes with Force Spectroscopy. Carleen M. Bowers, David A. Carlson, Monica Rivera, Robert L. Clark, and Eric J. Toone. Journal of Physical Chemistry B. 2013, 117 (17) pp 4755-4762. March 28, 2013. DOI: 10.1021/jp309393s.

Single-molecule anatomy by atomic force microscopy and recognition imaging. Hirohide Takahashi, Kohji Hizume, Masahiro Kumeta, Shige H. Yoshimura and Kunio Takeyasu. Archives of Histology and Cytology. 2009, 72 (4/5) pp 217-225. January 27, 2009. DOI: 10.1679/aohc.72.217.

Attaching Antibodies to AFM Probes with the Sulfhydryl Reactive PEG Tether, NHS-PEG18-PDP. W. Travis Johnson, Ph.D. Agilent Technologies, Inc. 2007, 5989-7702EN. December 18, 2007.

Cell recruitment and transfection in gene activated collagen matrix. Silvia Orsi, Antonia De Capua, Daniela Guarnieri, Daniela Marasco, Paolo A. Netti. Biomaterials. 2010, 31 (3) pp 570–576. January 2010. DOI: 10.1016/j.biomaterials.2009.09.054.

Structural characterization and functionalization of engineered spider silk films. Kristina Spieß, Stefanie Wohlrab and Thomas Scheibel. Soft Matter. 2010, 6 (17) pp 4168-4174. June 16, 2010. DOI: 10.1039/b927267d.

Nanoparticle Self-Assembly Directed by Antagonistic Kinase and Phosphatase Activities. Geoffrey von Maltzahn, Dal-Hee Min, Yingxin Zhang, Ji-Ho Park, Todd J. Harris, Michael Sailor, Sangeeta N. Bhatia. Advance Materials. 2007, 19 (21) pp 3579-3583. October 16, 2007. DOI: 10.1002/adma.200701183.

Cetuximab-conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging. Young-Seok Cho, Tae-Jong Yoon, Eue-Soon Jang, Kwan Soo Hong, Shin Young Lee, Ok Ran Kim, Cheongsoo Park, Yong-Jin Kim, Gyu-Chul Yi, Kiyuk Chang. Cancer Letters. 2010, 299 (1) pp 63-71. December 18, 2010. DOI: 10.1016/j.canlet.2010.08.004.

111In-Labeled Immunoconjugates (Ics) Bispecific for the Epidermal Growth Factor Receptor (EGFR) and Cyclin-Dependent Kinase Inhibitor, p27Kip1. Bart Cornelissen, Veerle Kersemans, Kristin McLarty, Lara Tran, Raymond M. Reilly. Cancer Biotherapy and Radiopharmaceuticals. 2009, 24 (2) pp 163-173. May 1, 2009. DOI: 10.1089/cbr.2008.0553.

U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Rafal Goraczniak, Brian A Wall, Mark A Behlke, Kim A Lennox, Eric S Ho, Nikolas H Zaphiros, Christopher Jakubowski, Neil R Patel, Steven Zhao, Carlo Magaway, Stacey A Subbie, Lumeng Jenny Yu, Stephanie LaCava, Kenneth R Reuhl,Suzie Chen, and Samuel I Gunderson. Molecular Therapy–Nucleic Acids. 2013, 2 (e92). May 14, 2013. DOI: 10.1038/mtna.2013.24.

Small-Animal SPECT/CT of HER2 and HER3 Expression in Tumor Xenografts in Athymic Mice Using Trastuzumab Fab–Heregulin Bispecific Radioimmunoconjugates. Eva J. Razumienko, Deborah A. Scollard, and Raymond M. Reilly. The Journal of Nuclear Medicine. 2012, 53 (12) pp 1943–1950. October 24, 2012. DOI: 10.2967/jnumed.112.106906.

Mass Spectrometry-Guided Optimization and Characterization of a Biologically Active Transferrin−Lysozyme Model Drug Conjugate. Son N. Nguyen, Cedric E. Bobst, and Igor A. Kaltashov. Molecular Pharmaceutics. 2013, 10 (5) pp 1998−2007. March 27, 2013. DOI: org/10.1021/mp400026y.

A sandwich-type DNA array platform for detection of GM targets in multiplex assay. Sena Cansız, Can Ozen, Ceren Bayrac, A. Tahir Bayrac, Fatma Gul, Murat Kavruk, Remziye Yılmaz, Fusun Eyidogan, Huseyin, Avni Oktem. European Food Research and Technology. 2012, 235 (3) pp 429-437. July 6, 2012. DOI: 10.1007/s00217-012-1767-y.

A homogeneous fluorescent sensor for human serum albumin. Rongsheng E. Wang, Ling Tian, Yie-Hwa Chang. Journal of Pharmaceutical and Biomedical Analysis. 2012, 63 pp 165-169. April 7, 2012. DOI :10.1016/j.jpba.2011.12.035.

Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins. David J Marshall, Scott S Harried, John L Murphy, Chad A Hall, Mohammed S Shekhani, Christophe Pain, Conner A Lyons, Antonella Chillemi, Fabio Malavsi, Homer L Pearce, Jon S Thorson, and James R Prudent. MT Open. 2016. July 19, 2016. DOI: 10.1038/mt.2016.119.

Immune Response Modulation of Conjugated Agonists with Changing Linker Length. Keun Ah Ryu, Katarzyna Slowinska, Troy Moore, and Aaron Esser-Kahn. ACS Chemical Biology. 2016, October 17, 2016. DOI: 10.1021/acschembio.6b00895.

Chemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin. Hirobumi Fuchigami, Shino Manabe, Masahiro Yasunaga, and Yasuhiro Matsumura. Scientific Reports. 2018, 8 (14211) pp 1-9. September 21, 2018. DOI: 10.1038/s41598-018-32601-0.

A virus-like particle vaccine platform elicits heightened and hastened local lung mucosal antibody production after a single dose. Laura E. Richert, Amy E. Servid, Ann L. Harmsen, Agnieszka Rynda-Apple, Soo Han, James A. Wiley, Trevor Douglas, Allen G. Harmsen. Vaccine. 2012, 30 (24) pp 3653-3665. May 21, 2012. DOI: 10.1016/j.vaccine.2012.03.035.

Studying the effect of particle size and coating type on the blood kinetics of superparamagnetic iron oxide nanoparticles. Farnoosh Roohi, Jessica Lohrke, Andreas Ide, Gunnar Schütz, Katrin Dassler. International Journal of Nanomedicine. 2012, 7 pp 4447–4458. August 10, 2012. DOI: 10.2147/IJN.S33120.

Chlorotoxin Labeled Magnetic Nanovectors for Targeted Gene Delivery to Glioma. Forrest M. Kievit, Omid Veiseh, Chen Fang, Narayan Bhattarai, Donghoon Lee, Richard G. Ellenbogen and Miqin Zhang. ACS Nano. 2010, 4 (8) pp 4587–4594. July 20, 2010. DOI: 10.1021/nn1008512.

Creating Antibacterial Surfaces with the Peptide Chrysophsin‑1. Ivan E. Ivanov, Alec E. Morrison, Jesse E. Cobb, Catherine A. Fahey, and Terri A. Camesano. ACS Applied Materials & Interfaces. 2012, 4 (11) pp 5891−5897. October 8, 2012. DOI: 10.1021/am301530a.

Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery. Omid Veiseh, Forrest M. Kievit, Chen Fang, Ni Mu, Soumen Jana, Matthew C. Leung, Hyejung Mok, Richard G. Ellenbogen, James O. Park, Miqin Zhang. Biomaterials. 2010, 31 (31) pp 8032-8042. November 2010. DOI: 10.1016/j.biomaterials.2010.07.016.

Development of a widefield SERS imaging endoscope. Patrick Z .McVeigh, Rupananda J. Mallia, Israel Veilleux, Brian C. Wilson. SPIE Proceedings. 2012, 8217 (1) pp 1-6. February 13, 2012. DOI: 10.1117/12.907304.

Intravital confocal Raman microscopy with multiplexed SERS contrast agents. Patrick Z. McVeigh, Brian C Wilson. Plasmonics in Biology and Medicine IX. 2012, 8234 PP 82340D. February 9, 2012. DOI: 10.1117/12.907048.

Single-molecule imaging, force measurement and fluorescence observation reveal protein and chromosome dynamics around the nuclear envelope. S. Otsuka, Y. Hirano, H. Takahashi, M. Kumeta, K. Takeyasu, and S.H Yoshimura. Micro-NanoMechatronics and Human Science. 2007, pp 310-315. December 1, 2007. DOI: 10.1109/MHS.2007.4420872.

New concept of cytotoxic immunoconjugate therapy targeting cancer-induced fibrin clots. Yasunaga M, Manabe S, Matsumura Y. Cancer Science. 2011, 102 (7) pp 1396-1402. May 9, 2011. DOI: 10.1111/j.1349-7006.2011.01954.x.

Rapid ratiometric biomarker detection with topically applied SERS nanoparticles. Yu “Winston” Wang, Altaz Khan, Madhura Som, Danni Wang, Ye Chen, Steven Y. Leigh, Daphne Meza, Patrick Z. McVeigh, Brian C. Wilson and Jonathan T.C. Liu. Technology. 2014, 2 (2) pp 1-15. June 2014. DOI: 10.1142/S2339547814500125.

Aptamer-targeted Antigen Delivery. Brian C Wenerter, Joseph A Katakowski, Jacob M Rosenberg, Chae Gyu Park, Steven C Almo, Deborah Palliser and Matthew Levy. Molecular Therapy. 2014, 22 (7) pp 1375-1387. May 6, 2014. DOI: 10.1038/mt.2014.51.

Targeted Intracellular Delivery of Proteins with Spatial and Temporal Control. Demosthenes P. Morales, Gary B. Braun, Alessia Pallaoro, Renwei Chen, Xiao Huang, Joseph A. Zasadzinski and Norbert O. Reich. Molecular Pharmaceutics. 2015, 12 (2) pp 600-609. December 9, 2014. DOI: 10.1021/mp500675p.

Control of Ultrasmall Sub-10 nm Ligand- Functionalized Fluorescent Core-Shell Silica Nanoparticle Growth in Water. Kai Ma, Carlie Mendoza, Margaret Hanson, Ulrike Werner-Zwanziger, Josef Zwanziger and Ulrich Wiesner. Chemistry of Materials. 2015, 27 (11) pp 4119-4133 May 13, 2015. DOI: 10.1021/acs.chemmater.5b01222.

Biocompatible and biodegradable fibrinogen microshperes for tumor-targeted doxorubicin delivery. Jae Yeon Joo, GilYong Park, and Seong Soo A An. International Journal of Nanomedicine. 2015, 10 pp 101-111. September 1, 2015. DOI: 10.2147/IJN.S88381.

3D Porous Chitosan-Alginate Scaffolds as an In Vitro Model for Evaluating Nanoparticle-Mediated Tumor Targeting and Gene Delivery to Prostate Cancer. Kui Wang, Forrest M. Kievit, Stephen J. Florczyk, Zachary R. Stephen, and Miqin Zhang. BioMacromolecules. 2015, September 8, 2015. DOI: 10.1021/acs.biomac.5b01032.

An Approach to Rapid Synthesis and Functionalization of Iron Oxide Nanoparticles for High Gene Transfection. Zachary Stephen, Christopher Dayringer, Josh Lim, Richard Revia, Mackenzie Halbert, Mike Jeon, Arvind Bakthavatsalam, Richard G Ellenbogen, and Miqin Zhang. ACS Applied Materials and Interfaces. 2016, 8(6) pp 3557-4266. February 19, 2016. DOI: 10.1021/acsami.5b10883.

Imaging mass spectrometry for the precise design of antibody-drug conjugates. Yuki Fujiwara, Masaru Furuta, Shino Manabe, Yoshikatsu Koga, Masahiro Yasunaga, and Yasuhiro Matsumura. Scientific Reports. 2016, 6 (24954). April 21, 2016. DOI: 10.1038/srep24954.

Spectroscopy Based Approaches for Detection of Ions, Alpha-L-Fucosidase, and Singlet Oxygen. Eric Waidely. University of Miami Scholarly Repository. 2017, pp 1-113. May 3, 2017. http://scholarlyrepository.miami.edu/oa_dissertations/1842.

Modular and Orthogonal Post-PEGylation Surface Modifications by Insertion Enabling Penta-functional Ultrasmall Organic-Silica Hybrid Nanoparticles. Kai Ma and Ulrich Wiesner. Chemistry of Materials. 2017, pp 1-18. July 23, 2017. DOI: 10.1021/acs.chemmater.7b02009.

Dissecting the cytochrome c2–reaction centre interaction in bacterial photosynthesis using single molecule force spectroscopy. Cvetelin Vasilev, Guy E. Mayneord, Amanda A. Brindley, Matthew P. Johnson, C. Neil Hunter. Biochemical Journal. 2019, 476 (15), pp 2173-2190. July 18, 2019. DOI: 10.1042/BCJ20170519.

Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Dina V. Hingorani, Aaron J. Lemieux, Joseph R. Acevedo, Heather L. Glasgow, Suraj Kedarisetty, Michael A. Whitney, Alfredo A. Molinolo, Roger Y. Tsien, Quyen T. Nguyena Oral Oncol. 2017 Aug;71:156-162. doi: 10.1016/j.oraloncology.2017.06.009. PMID: 28688684

Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers. Timon Hussain, Elamprakash N. Savariar, Julio A. Diaz–Perez, Karen Messer, Minya Pu, Roger Y. Tsien, Quyen T. Nguyen. Head Neck. 2016 May;38(5):715-23. doi: 10.1002/hed.23946. PMID: 25521629
MAL-dPEG®₂₄-NHS ester (#10314)
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, as well as his specific discussion with protocols of our MAL-dPEG®x-NHS esters on pp. 718-722.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Antigen Peptide-Based Immunosensors for Rapid Detection of Antibodies and Antigens. Ling Tian and Tomasz Heyduk. Analytical Chemistry. 2009, 81 (13) pp 5218–5225. May 26, 2009. DOI: 10.1021/ac900845a.

Characterization and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker. Lisa M. Kaminskas, Brian D. Kelly, Victoria M. McLeod, Gian Sberna, David J. Owen, Ben J. Boyd, Christopher J.H. Porter. Journal of Controlled Release. 2011, 152 (2) Pages 241-248. June 10, 2011. DOI: 10.1016/j.jconrel.2011.02.005.

Device for continuous extracorporeal blood purification using target-specific metal nanomagnets. Inge K. Herrmann, Riccardo E. Bernabei, Martin Urner, Robert N. Grass, Beatrice Beck-Schimmer and Wendelin J. Stark. Nephrol Dial Transplant. 2011, 26 (9) pp 2948-2954. February 10, 2011. DOI: 10.1093/ndt/gfq846.

Functional improvement of an IRQ-PEG-MEND for delivering genes to the Lung. Taichi Ishitsuka, Hidetaka Akita, Hideyoshi Harashima. Journal of Controlled Release. 2011, 154 (1) pp 77-83, August 25, 2011. DOI: 10.1016/j.jconrel.2011.05.012.

Interactive Configuration through Force Analysis of GM1 Pentasaccharide-Vibrio cholera Toxin Interaction. Jeong Hyun Seo, Chang Sup Kim, Hea Yeon Lee, Tomoji Kawai, and Hyung Joon Cha. Analytical Chemistry. 2011, 83 (15) pp 6011–6017. June 24, 2011. DOI: 10.1021/ac201013p.

Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Jiang Xia, Elin Bergseng, Burkhard Fleckenstein, Matthew Siegel, Chu-Young Kim, Chaitan Khosla and Ludvig M. Sollid. Bioorganic & Medicinal Chemistry. 2007, 15 (20), pp 6565–6573. October 15, 2007. DOI:10.1016/j.bmc.2007.07.001.

Efficient capture of circulating tumor cells with a novel immunocytochemical microfluidic device. Mary Nora Dickson, Pavel Tsinberg, Zhongliang Tang, Farideh Z. Bischoff, Timothy Wilson, and Edward F. Leonard. Biomicrofluidics. 2011, 5 (3). August 22, 2011. DOI: 10.1063/1.3623748.

A methodology for preparing nanostructured biomolecular interfaces with high enzymatic activity. Lu Shin Wong, Chinnan V. Karthikeyan, Daniel J. Eichelsdoerfer, Jason Micklefield and Chad A. Mirkin. Nanoscale. 2012, 4 (2) pp 659-666. December 8, 2011. DOI:10.1039/C1NR11443C.

Investigation of the Interaction between a Bivalent Aptamer and Thrombin by AFM. Lin Ge, Gang Jin and Xiaohong Fang. Langmuir. 2012, 28 (1) pp 707–713. November 21, 2011. DOI: 10.1021/la203954x.

Immobilization of hydrophobic peptidic ligands to hydrophilic chromatographic matrix: A preconcentration approach. Satyen Gautam, Kai-Chee Loh. Analytical Biochemistry. 2012, 423 (2) pp 202-209. April 15, 2012. DOI: 10.1016/j.ab.2012.01.020.

Targeting of Primary Breast Cancers and Metastases in a Transgenic Mouse Model Using Rationally Designed Multifunctional SPIONs. Forrest M. Kievit, Zachary R. Stephen, Omid Veiseh, Hamed Arami, Tingzhong Wang, Vy P. Lai, James O. Park, Richard G. Ellenbogen, Mary L. Disis, and Miqin Zhang. ACS Nano. 2012, 6 (3) pp 2591–2601. February 10, 2012. DOI: 10.1021/nn205070h.

Subcellular trafficking and transfection efficacy of polyethylenimine-polyethylene glycol polyplex nanoparticles with a ligand to melanocortin receptor-1. Mikhail O. Durymanov, Elena A. Beletkaia, Alexey V. Ulasov, Yuri V. Khramtsov, Georgiy A. Trusov, Nikita S. Rodichenko, Tatiana A. Slastnikova, Tatiana V. Vinogradova, Natalia Y. Uspenskaya, Eugene P. Kopantsev, Andrey A. Rosenkranz, Eugene D. Sverdlov, Alexander S. Sobolev. Journal of Controlled Release. 2012, 163 (2) pp 211-219. October 28, 2012. DOI: 10.1016/j.jconrel.2012.08.027.

Antibody-Unfolding and Metastable-State Binding in Force Spectroscopy and Recognition Imaging. Parminder Kaur, Qiang-Fu, Alexander Fuhrmann, Robert Ros, Linda Obenauer Kutner, Lumelle A. Schneeweis, Ryman Navoa,Kirby Steger, Lei Xie, Christopher Yonan, Ralph Abraham, Michael J. Grace, and Stuart Lindsay. Biophysical Journal. 2011, 100 (1) pp 243-250. January 5, 2011. DOI:10.1016/j.bpj.2010.11.050.

Enhanced transfection of tumor cells in vivo using “Smart” pH-sensitive TAT-modified pegylated liposomes. Amit A. Kale and Vladimir P. Torchilin. Journal of Drug Targeting. 2007, 15 (7-8) pp 538-545. September 13, 2007. DOI:10.1080/10611860701498203.

Multifunctional nanoagent for thrombus-targeted fibrinolytic Therapy. Jason R. McCarthy, Irina Y. Sazonova, S. Sibel Erdem, Tetsuya Hara, Brian D. Thompson, Purvish Patel, Ion Botnaru, Charles P. Lin, Guy L. Reed, Ralph Weissleder, and Farouc A. Jaffer. Nanomedicine 2012 7 (7) pp 1017–1028. February 21, 2012. DOI:10.2217/nnm.11.179.

Properties of PEI-based Polyplex Nanoparticles That Correlate With Their Transfection Efficacy. Alexey V Ulasov, Yuri V Khramtsov, Georgiy A Trusov, Andrey A Rosenkranz, Eugene D Sverdlov and Alexander S Sobolev. Molecular Therapy. 2011, 19 (1) pp 103-112. November 2, 2010. DOI:10.1038/mt.2010.233.

Genetic PEGylation. Seiichi Tada, Takashi Andou, Takehiro Suzuki, Naoshi Dohmae, Eiry Kobatake and Yoshihiro Ito. PLoS One. 2012, 7 (11) pp e49235. November 8, 2012. DOI:10.1371/journal.pone.0049235.

Human pIgR mimetic peptidic ligand for affinity purification of IgM Part II: Ligand binding characteristics. Satyen Gautam, Kai-Chee Loh. Separation and Purification Technology. 2013, 102 pp 43–49. January 4, 2013. DOI: 10.1016/j.seppur.2012.09.024.

Attaching Antibodies to AFM Probes with the Sulfhydryl Reactive PEG Tether, NHS-PEG18-PDP. W. Travis Johnson, Ph.D. Agilent Technologies, Inc. 2007, 5989-7702EN. December 18, 2007.

Biomimetic Ligands for Immunoglobulin-M Purification. Satyen Gautam. Doctoral Dissertation, National University of Singapore: Singapore, April 12, 2010. DOI: www.scholarbank.nus.edu.sg/handle/10635/22872.

Development of a novel bead-based96-well filtrationplate competitive immunoassay for the detection of Gentamycin. Tien Yu Jessica Ho, Chia-ChungChan, KingHoChan, YuChiehWang, Jing-TangLin, Cheng-Ming Chang, Chien-ShengChen. Biosensors and Bioelectronics. 2013, 49 pp 126–132. November 15,2013. DOI: 10.1016/j.bios.2013.04.027.

MicroSPECT/CT imaging of co-expressed HER2 and EGFR on subcutaneous human tumor xenografts in athymic mice using 111In-labeled bispecific radioimmunoconjugates. Eva Razumienko, Lindsay Dryden,

Deborah Scollard, Raymond M. Reilly. Breast Cancer Research and Treatment. 2013, 138 (3) pp 709-718. March 24, 2013. DOI: 10.1007/s10549-013-2490-5.

Small-Animal SPECT/CT of HER2 and HER3 Expression in Tumor Xenografts in Athymic Mice Using Trastuzumab Fab–Heregulin Bispecific Radioimmunoconjugates. Eva J. Razumienko, Deborah A. Scollard, and Raymond M. Reilly. Journal of Nuclear Medicine. 2012, 53 (12) pp 1943–1950. October 24, 2012. DOI: 10.2967/jnumed.112.106906.

Delivery of Small Interfering RNA by Peptide-Targeted Mesoporous Silica Nanoparticle-Supported Lipid Bilayers. Carlee E. Ashley, Eric C. Carnes, Katharine E. Epler, David P. Padilla, Genevieve K. Phillips, Robert E. Castillo, Dan C. Wilkinson, Brian S. Wilkinson, Cameron A. Burgard, Robin M. Kalinich, Jason L. Townson, Bryce Chackerian, Cheryl L. Willman, David S. Peabody, Walker Wharton and C. Jeffrey Brinker. ACS Nano. 2012, 6 (3) pp 2174-2188. February 6, 2012. DOI: 10.1021/nn204102q.

BMP-2 tethered hydroxyapatite for bone tissue regeneration: Coating chemistry and osteoblast attachment. Stefanie M. Shiels, Kimberly D. Solomon, Marcello Pilia,Mark R. Appleford, Joo L. Ong. Journal of Biomedical Materials Research. 2012, 100A (11) pp 3117-3123. July 20, 2012. DOI: 10.1002/jbm.a.34241.

Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins. David J Marshall, Scott S Harried, John L Murphy, Chad A Hall, Mohammed S Shekhani, Christophe Pain, Conner A Lyons, Antonella Chillemi, Fabio Malavsi, Homer L Pearce, Jon S Thorson, and James R Prudent. MT Open. 2016. July 19, 2016. DOI: 10.1038/mt.2016.119.

A study of polyethylene glycol backfilling for enhancing target recognition using QCM-D and DPI. Yanqiu Du, Jing Jin, and Wei Jiang. Journal of Materials Chemistry B. 2018, 6, pp 6217-6224. September 21, 2018. DOI: 10.1039/c8tb01526k.

Protein purification to analyze AAA+ proteolytic machine in vitro. Diego Rojas. Columbia University Academic Commons. 2011.

Nanomechanics of HaloTag Tethers. Ionel Popa, Ronen Berkovich, Jorge Alegre-Cebollada, Carmen L. Badilla, Jaime Andrés Rivas-Pardo, Yukinori Taniguchi, Masaru Kawakami, and Julio M. Fernandez. Journal of the American Chemical Society. 2013, 135 (34) pp 12762–12771. August 2, 2013. DOI: 10.1021/ja4056382.

SNAP-Tag Technology Mediates Site Specific Conjugation of Antibody Fragments with a Photosensitizer and Improves Target Specific Phototoxicity in Tumor Cells. Ahmad Fawzi Hussain, Florian Kampmeier, Verena von Felbert, Hans-F. Merk, Mehmet Kemal Tur, and Stefan Barth. Bioconjugate Chemistry. 2011, 22 (12) pp 2487–2495. October 13, 2011. DOI: 10.1021/bc200304k.

Application of HaloTag Protein to Covalent Immobilization of Recombinant Proteins for Single Molecule Force Spectroscopy. Yukinori Taniguchi and Masaru Kawakami. Langmuir. 2010, 26 (13) pp 10433–10436. June 9, 2010. DOI: 10.1021/la101658a.

Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles. Matthias T. Stephan, Sirkka B. Stephan, Peter Bak, Jianzhu Chen, Darrell J. Irvine. Biomaterials. 2012, 33 (23) pp 5776-5787. August 2012. DOI: 10.1016/j.biomaterials.2012.04.029.

Photodynamic characterization and optimization using multifunctional nanoparticles for brain cancer treatment. Kristen Herrmann, Yong-Eun Lee Koo, Daniel A. Orringer, Oren Sagher, Martin Philbert, Raoul Kopelman. SPIE Proceedings. 2013, 8568 (1) pp 1-8. March 13, 2013. DOI: 10.1117/12.2005530.

“Smart” Drug Carriers: PEGylated TATp-Modified pH-Sensitive Liposomes. Amit A. Kale and Vladimir P. Torchilin. Journal of Liposome Research. 2007, 17(3-4) pp 197-203. June 6, 2007. DOI: 10.1080/08982100701525035.

Therapeutic Anti-Methamphetamine Antibody Fragment-Nanoparticle Conjugates: Synthesis and in Vitro Characterization. Nisha Nanaware-Kharade , Guillermo A. Gonzalez , III, Jackson O. Lay , Jr., Howard P. Hendrickson , and Eric C. Peterson. Bioconjugate Chemistry. 2012, 23 (9) pp 1864–1872. August 9, 2012. DOI: 10.1021/bc300204n.

Molecular Pincers: Antibody-Based Homogeneous Protein Sensors. Ewa Heyduk, Benjamin Dummit, Yie-Hwa Chang, and Tomasz Heyduk. Analytical Chemistry. 2008, 80 (13) pp 5152-5159. May 21, 2008. DOI: 10.1021/ac8004154.

Specific Binding at the Cellulose Binding Module-Cellulose Interface Observed By Force Spectroscopy. Jason R King, Carleen M. Bowers and Eric J Toone. Langmuir. 2015, 31 (11) March 4, 2015. DOI: 10.1021/la504836u.

A Nanotechnology-Based Platform for Extending the Pharmacokinetic and Binding Properties of Anti-methamphetamine Antibody Fragments. Nisha Nanaware-Kharade, shraddha Thakkar, Guillermo A. Gonzalez III, and Eric C. Peterson. Scientific Reports. 2014, 5 (12060). July 10, 2015. DOI: 10.1038/srep12060.

Serum albumin ‘camouflage’ of plant virus based nanoparticles prevents their antibody recognition and enhances pharmacokinetics. Andrzej S. Pitek, Slater A. Jameson, Frank A. Veliz, Sourabh Shukla, and Nicole F. Steinmetz. Biomaterials. 2016, 89 pp 89-97, February 23, 2016. DOI: 10.1016/j.biomaterials.2016.02.032.

Optimization, Production and Characterization of a CpG-Oligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen. Bob Milley, Radwan Kiwan, Gary S. Ott, Carlo Calacsan, Melissa Kachura, John D Campbell, Holger Kanzler, and Robert L. Coffman. Bioconjugate Chemistry. 2016, April 13, 2016. DOI: 10.1021/acs.bioconjchem.6b00107.

Application of vasoactive and matrix-modifying drugs can improve polypex delivery to tumors upon intravenous administration. Mikhail O. Durymanov, Alexey V. Yarutkin, Dmitry V. Bagrov, Dmitry V. Klinov, Alexander V. Kedrov, Nikolay K. Chemeris, Andrey A. Rosenkranz, and Alexander S. Sobolev. Journal of Controlled Release. 2016, 232 pp 20-28. April 6, 2016. DOI: 10.1016/j.jconrel.2016.04.011.

Surface Force Analysis of Pyrite (FeS2): Its Reactivity to Amino Acid Adsorption. Narangerel Ganbaatar, Nina Matsuzaki, Yuya Nakazawa, Rehana Afrin, Masashi Aono, Taka-aki Yano, Tomohiro Hayashi, and Masahiko Hara. Advances in Materials Physics and Chemistry. 2016, 6, pp 167-176. June 30, 2016. http://dx.doi.org/10.4236/ampc.2016.67018.

Immune Response Modulation of Conjugated Agonists with Changing Linker Length. Keun Ah Ryu, Katarzyna Slowinska, Troy Moore, and Aaron Esser-Kahn. ACS Chemical Biology. 2016, October 17, 2016. DOI: 10.1021/acschembio.6b00895.

Tumor tissue slice cultures as a platform for analyzing tissue-penetration and biological activities of nanoparticles. Lea Merz, Sabrina Hobel, Sonja Kallendrusch, Alexander Ewe, Ingo Bechmann, Heike Franke, Felicitas Merz, and Achim Aigner. Science Direct. 2016, 112, pp 45-50. http://dx.doi.org/10.1016/j.ejpb.2016.11.0163.

Optimized polyethylenimine (PEI)-based nanoparticles for siRNA delivery, analyzed in vitro and in an ex vivo tumor tissue slice culture model. Alexander Ewe, Sabrina Hobel, Claudia Heine, Lea Merz, Sonja Kallendrusch, Ingo Bechmann, Felicitas Merz, Heike Franke, Achim Aigner. Drug Delivery and Translational Research. 2016, pp 1-11. June 22, 2016. DOI: 10.1007/s13346-016-0306-y.

Development of Raman Spectroscopy as a clinical Diagnostic Tool. Santa Borel. Doctoral Disseratation, University of Toronto, Toronto, Ontario, Canada. 2016, pp 1-99. November 2016. https://tspace.library.utoronto.ca/handle/1807/74538.

Mapping of Molecular Structure of the Nanoscale Surface in Bio-nanoparticles. Luciana M Herda, Delyan R Hristov, Maria Cristina Lo Giudice, Ester Polo, and Kenneth A Dawson. Journal of the American Chemical Society. 2016. December 22, 2016. DOI: 10.1021/jacs.6b12297.

64Cu-Labeled Trastuzumab Fab-PEG24-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR-Pharmacokinetics, Biodistribution, and Tumor Imaging by PET in Comparison to Monospecific Agents. Luke (Yongkyu) Kwon, Deborah A Scollard, and Raymond M Reilly. Molecular Pharmaceutics. 2017, pp 1-38. January 3, 2017. DOI: 10.1021/acs.molpharmaceut.6b00963.

Quantitative Evaluation of Viral Protein Binding to Phosphoinositide Receptors and Pharmacological Inhibition. Seong-Oh Kim, Joshua A. Jackman, Menashe Elazar, Sang-Joon Cho, Jeffrey S Glenn, and Nam-Joon Cho. Analytical Chemistry. 2017, August 15, 2017. DOI: 10.1021/acs.analchem.7b01568.

Silica Nanoparticles for the Delivery of DNA and RNAi in Cancer Treatment. Michael Aaron Vrolijk. Graduate College Dissertations and Theses. 2017, pp 1-122. May 22, 2017. http://scholarworks.uvm.edu/graddis/783.

Inhibition of Myeloperoxidase Activity in Cystic Fibrosis Sputum by Peptide Inhibitor of Complement C1 (PIC1). Pamela S. Hair, Laura A. Sass, Neel K. Krishna, and Kenji M. Cunnion. PLOS one. 2017, 12 (1) e0170203. January 30, 2017. DOI: 10.1371/journal.pone.0170203.

Elongated plant virus-based nanoparticles for enhanced delivery of thrombolytic therapies. Andrzej Stanislaw Pitek, Yunmei Wang, Sahil Gulati, Huiyun Gao, Phoebe L Stewart, Daniel I. Simon, and Nicole F Steinmetz. Molecular Pharmaceutics. 2017, pp 1-9. September 7, 2017. DOI: 10.1021/acs.molpharmaceut.7b00559.

Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis. Abdulrahman Ahmed Mahmood, Jianqi Zhang, Rufang Liao, Xiwei Pan, Dan Xu, Haibo Xu, Qibing Zhou. RSC Advances. 2019, 9, 14051-14059. May 7, 2019. DOI: 10.1039/C9RA02430A.

Hydrogel Skin-Covered Neurons Self-Assembled with Gustatory Cells for Selective Taste Stimulation. Trang Huyen Le-Kim, Bon Il Koo, Jun Su Yun, Seung-Woo Cho, Yoon Sung Nam. ACS Omega. 2019, 4, 7, pp 12393-12401. July 19, 2019. DOI: 10.1021/acsomega.9b00998

Cell-Specific Delivery of Diverse Cargos by BacteriophageMS2 Virus-like Particles. Carlee E. Ashley Eric C. Carnes, Genevieve K. Phillips, Paul N. Durfee, Mekensey D. Buley, Christopher A. Lino, David P. Padilla, Brandy Phillips, Mark B. Carter, Cheryl L. Willman, C. Jeffrey Brinker, Jerri do Carmo Caldeira, Bryce Chackerian, Walker Wharton, and David S. Peabody.ACS Nano, 2011, 5 (7), pp 5729–5745, May 26, 2011. DOI: 10.1021/nn201397z.