copper free click chemistry Archives

This reaction scheme shows how to use Quanta BioDesign's product number 10524, Azido-dPEG®11-amine, as a click chemistry crosslinking reagent. In the scheme, the amine end of molecule is reacted with a carboxylate group forming an amide bond with R1. Subsequently, the azide end of the molecule reacts by click chemistry (either copper(I)-catalyzed or strain-promoted azide-alkyne cycloaddition) to crosslink R1 with R2.

Three Click Chemistry Crosslinking Ideas with dPEG^®

June 18, 2020
QuantaBioDesign
Blog, Product Reviews
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Have you ever been working your way through a product catalog when you've come across a product you weren't sure how to use? I know I have. In those "What do I do with this?" moments, tips that explain how…

Figure 2: General chemical structure of Quanta BioDesign's DBCO-dPEG® TFP ester products for crosslinking azides and amines.

Copper-free Click Chemistry to Crosslink Azides and Amines

June 11, 2020
QuantaBioDesign
Blog, Product Reviews
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Quanta BioDesign's monodispersed, discrete PEG (dPEG®) products include a wide range of useful tools for click chemistry. Most of our reagents are designed to enable copper-free click chemistry, which is essential for biocompatible labeling and crosslinking. Copper-free click chemistry that…