Tag: crosslinker

Three Click Chemistry Ideas for PEGylation Reagents

Have you ever been working your way through a product catalog and encountered a product you weren’t sure how to use? I know I have. It helps in those moments of “What do I do with this?” to have some tips on how to use a product effectively. Today I want to take one of our unique click chemistry discrete PEGylation (dPEG®) reagents, PN10524, azido-dPEG®11-amine, and offer three ideas on how to get the most out of it in an application. Continue reading

Graph showing the relationship of dPEG® linker length in relation to potency and specificity in extracellular drug conjugates.

Extracellular Drug Conjugates Therapeutically Exploit Protein Proximity

Pharmaceutical company Centrose, founded by James R. Prudent, Ph.D., developed a new class of antibody drug conjugates called extracellular drug conjugates. Nature Publishing Group published the research as a open access paper in its Molecular Therapy journal.1 Apart from the interesting and important development of a new class of antibody drug conjugate (ADC), the research also showed how important linker length 2 is to the potency and specificity of the EDC. Continue reading